pyridoxal phosphate has been researched along with Manganese Poisoning in 7 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Manganese Poisoning: Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Manganese (Mn) is a required element and a metabolic byproduct of the contrast agent mangafodipir trisodium (MnDPDP)." | 2.42 | Manganese toxicity upon overexposure. ( Crossgrove, J; Zheng, W, 2004) |
| " Skeletal malformations, identical to those seen in the previous study, were increased in a dose-dependent manner with the highest incidence occurring in fetuses from females dosed from days 15-17 of gestation." | 1.29 | Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats. ( Blazak, WF; Gray, TJ; Treinen, KA, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (85.71) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crossgrove, J | 1 |
| Zheng, W | 1 |
| Treinen, KA | 1 |
| Gray, TJ | 1 |
| Blazak, WF | 2 |
| Jynge, P | 1 |
| Brurok, H | 1 |
| Asplund, A | 1 |
| Towart, R | 1 |
| Refsum, H | 1 |
| Karlsson, JO | 1 |
| Grant, D | 2 |
| Brown, GL | 1 |
| Larsen, LE | 1 |
| Elizondo, G | 1 |
| Fretz, CJ | 1 |
| Stark, DD | 2 |
| Rocklage, SM | 2 |
| Quay, SC | 2 |
| Worah, D | 1 |
| Tsang, YM | 1 |
| Chen, MC | 1 |
| Ferrucci, JT | 1 |
| Lim, KO | 1 |
| Leese, PT | 1 |
| Pfefferbaum, A | 1 |
3 reviews available for pyridoxal phosphate and Manganese Poisoning
| Article | Year |
|---|---|
Manganese toxicity upon overexposure.
Topics: Animals; Brain; Contrast Media; Edetic Acid; Heart; Humans; Manganese; Manganese Poisoning; Myocardi | 2004 |
Cardiovascular safety of MnDPDP and MnCl2.
Topics: Animals; Cardiovascular System; Chlorides; Contrast Media; Dose-Response Relationship, Drug; Edetic | 1997 |
General toxicology of MnDPDP.
Topics: Animals; Contrast Media; Dose-Response Relationship, Drug; Drug Tolerance; Edetic Acid; Female; Male | 1997 |
1 trial available for pyridoxal phosphate and Manganese Poisoning
| Article | Year |
|---|---|
Hepatobiliary MR imaging: first human experience with MnDPDP.
Topics: Adult; Contrast Media; Drug Evaluation; Edetic Acid; Humans; Liver; Magnetic Resonance Imaging; Male | 1991 |
3 other studies available for pyridoxal phosphate and Manganese Poisoning
| Article | Year |
|---|---|
Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Chlorides; Contrast Media; Dose-Response Relat | 1995 |
The reproductive toxicology of intravenously administered MnDPDP in the rat and rabbit.
Topics: Abnormalities, Drug-Induced; Animals; Contrast Media; Dose-Response Relationship, Drug; Edetic Acid; | 1997 |
Preclinical evaluation of MnDPDP: new paramagnetic hepatobiliary contrast agent for MR imaging.
Topics: Animals; Contrast Media; Dogs; Drug Evaluation, Preclinical; Edetic Acid; Female; Lethal Dose 50; Li | 1991 |