pyridoxal phosphate has been researched along with Hypoxia-Ischemia, Brain in 12 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations." | 3.80 | Pyridoxine responsiveness in novel mutations of the PNPO gene. ( Abela, L; Clayton, P; Connolly, M; Hasselmann, O; Hofer, D; Kanz, S; Maier, O; Mills, P; Paschke, E; Paul, K; Plecko, B; Schmiedel, G; Stockler, S; Struys, E; Wolf, N, 2014) |
| "In spite of effective seizure control with PLP, approximately 56% of patients affected with PLP-dependent epilepsy suffer developmental delay/intellectual disability." | 2.72 | Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency. ( Abdelhakim, M; Adly, N; Alghamdi, M; Alghanem, B; Arold, ST; Bashiri, FA; Jamjoom, DZ; Sumaily, KM, 2021) |
| "About 7/18 (39%) of patients showed seizure-free with pyridoxine (PN) or pyridoxal-5'-phosphate treatment." | 1.91 | Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency. ( Gong, P; Jiao, X; Niu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023) |
| "Neonatal onset seizures in PLP responsive epilepsy are usually resistant to common anticonvulsants and pyridoxine, but respond to PLP." | 1.42 | Pyridoxal 5ꞌ-phosphate-responsive epilepsy with novel mutations in the PNPO gene: a case report. ( Damrongphol, P; Ittiwut, C; Ittiwut, R; Shotelersuk, V; Suphapeetiporn, K; Veeravigrom, M, 2015) |
| " After a single intraperitoneal injection of low dosage with 0." | 1.35 | Manganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP. ( Wu, EX; Yang, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Barile, A | 2 |
| Mills, P | 2 |
| di Salvo, ML | 2 |
| Graziani, C | 1 |
| Bunik, V | 2 |
| Clayton, P | 2 |
| Contestabile, R | 2 |
| Tramonti, A | 2 |
| Jiao, X | 1 |
| Gong, P | 1 |
| Niu, Y | 1 |
| Xu, Z | 1 |
| Zhang, Y | 1 |
| Yang, Z | 1 |
| Nogués, I | 1 |
| Alghamdi, M | 1 |
| Bashiri, FA | 1 |
| Abdelhakim, M | 1 |
| Adly, N | 1 |
| Jamjoom, DZ | 1 |
| Sumaily, KM | 1 |
| Alghanem, B | 1 |
| Arold, ST | 1 |
| Ghatge, MS | 1 |
| Al Mughram, M | 1 |
| Omar, AM | 1 |
| Safo, MK | 1 |
| Guerriero, RM | 1 |
| Patel, AA | 1 |
| Walsh, B | 1 |
| Baumer, FM | 1 |
| Shah, AS | 1 |
| Peters, JM | 1 |
| Rodan, LH | 1 |
| Agrawal, PB | 1 |
| Pearl, PL | 1 |
| Takeoka, M | 1 |
| Ware, TL | 1 |
| Earl, J | 2 |
| Salomons, GS | 1 |
| Struys, EA | 1 |
| Peters, HL | 1 |
| Howell, KB | 1 |
| Pitt, JJ | 1 |
| Freeman, JL | 1 |
| Plecko, B | 1 |
| Paul, K | 1 |
| Paschke, E | 1 |
| Maier, O | 1 |
| Hasselmann, O | 1 |
| Schmiedel, G | 1 |
| Kanz, S | 1 |
| Connolly, M | 1 |
| Wolf, N | 1 |
| Struys, E | 1 |
| Stockler, S | 1 |
| Abela, L | 1 |
| Hofer, D | 1 |
| Veeravigrom, M | 1 |
| Damrongphol, P | 1 |
| Ittiwut, R | 1 |
| Ittiwut, C | 1 |
| Suphapeetiporn, K | 1 |
| Shotelersuk, V | 1 |
| Xiao, J | 1 |
| Huang, Y | 1 |
| Li, X | 1 |
| Li, L | 1 |
| Yang, T | 1 |
| Huang, L | 1 |
| Yang, L | 1 |
| Jiang, H | 1 |
| Li, H | 1 |
| Li, F | 1 |
| Yang, J | 1 |
| Wu, EX | 1 |
| Balasubramaniam, S | 1 |
| Bowling, F | 1 |
| Carpenter, K | 1 |
| Chaitow, J | 1 |
| Pitt, J | 1 |
| Mornet, E | 1 |
| Sillence, D | 1 |
| Ellaway, C | 1 |
2 reviews available for pyridoxal phosphate and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency.
Topics: Brain Diseases, Metabolic; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Mutation; | 2021 |
Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies.
Topics: Animals; Brain Diseases, Metabolic; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Metabolism, In | 2021 |
10 other studies available for pyridoxal phosphate and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5'-Phosphate Oxidase-Dependent Epilepsy.
Topics: Brain Diseases, Metabolic; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Metabolic Dis | 2021 |
Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency.
Topics: Brain Diseases, Metabolic; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Oxidoreductases; Pho | 2023 |
Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy.
Topics: Allosteric Regulation; Allosteric Site; Brain Diseases, Metabolic; Catalytic Domain; Crystallography | 2020 |
Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency.
Topics: Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Female; Humans; Hypoxia-Ischemia, Brain | 2017 |
Typical and atypical phenotypes of PNPO deficiency with elevated CSF and plasma pyridoxamine on treatment.
Topics: Brain Diseases, Metabolic; Child; Child, Preschool; Electroencephalography; Humans; Hypoxia-Ischemia | 2014 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Aldehyde Dehydrogenase; Alleles; Animals; Brain Diseases, Metabolic; CHO Cells; Chromosome Deletion; | 2014 |
Pyridoxal 5ꞌ-phosphate-responsive epilepsy with novel mutations in the PNPO gene: a case report.
Topics: Brain Diseases, Metabolic; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Mutation; Pyrid | 2015 |
TNP-ATP is Beneficial for Treatment of Neonatal Hypoxia-Induced Hypomyelination and Cognitive Decline.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Cognition Disorders; Disease Models, Anima | 2016 |
Manganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP.
Topics: Animals; Animals, Newborn; Contrast Media; Edetic Acid; Female; Hypoxia-Ischemia, Brain; Magnetic Re | 2009 |
Perinatal hypophosphatasia presenting as neonatal epileptic encephalopathy with abnormal neurotransmitter metabolism secondary to reduced co-factor pyridoxal-5'-phosphate availability.
Topics: Alkaline Phosphatase; Anticonvulsants; Biogenic Monoamines; Brain Diseases, Metabolic; Fatal Outcome | 2010 |