pyridoxal phosphate has been researched along with Hyperhomocysteinemia in 21 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Hyperhomocysteinemia: Condition in which the plasma levels of homocysteine and related metabolites are elevated (
| Excerpt | Relevance | Reference |
|---|---|---|
| " Despite association found between PLP deficiency and low antioxidant status in critically ill patients, PLP deficiency was only associated with hyperhomocysteinemia regardless of antioxidant, riboflavin, cobalamine, and folate statuses in critically ill patients with SIRS at seventh day of ICU stay." | 7.83 | Pyridoxal-5'-phosphate deficiency is associated with hyperhomocysteinemia regardless of antioxidant, thiamine, riboflavin, cobalamine, and folate status in critically ill patients. ( de la Cruz, AP; Del Pozo, EP; Florea, D; Molina-López, J; Quintero-Osso, B; Rodríguez-Elvira, M, 2016) |
| " Hyperhomocysteinemia is a well-recognized risk factor for cardiovascular disease; however, its association with ST use has never been investigated." | 7.79 | Smokeless tobacco use: a risk factor for hyperhomocysteinemia in a Pakistani population. ( Iqbal, MP; Yakub, M, 2013) |
| "The purpose of this study was to determine if nonsupplementing older women (aged >or=55 years) with rheumatoid arthritis had higher plasma homocysteine and lower B-vitamin status compared to healthy controls." | 7.74 | Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis. ( Manore, MM; Woolf, K, 2008) |
| " We investigated the possible correlation between deficiency of vitamins B6, B12 or folic acid and hyperhomocysteinemia in Pakistani patients with acute myocardial infarction (AMI)." | 7.73 | Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction. ( Ali, SA; Iqbal, MP; Ishaq, M; Kazmi, KA; Khan, AH; Mehboobali, N; Waqar, MA; Yousuf, FA, 2005) |
| "To evaluate the prevalence of moderate fasting hyperhomocysteinemia (HHcy) and postmethionine load (PML) HHcy among patients with early-onset central retinal vein occlusion (CRVO)." | 7.73 | Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion. ( Brancato, R; D'Angelo, A; Fattorini, A; Lattanzio, R; Ramoni, A; Sampietro, F, 2006) |
| "The antiparkinsonian drug L-dopa causes increased cellular synthesis of homocysteine and consequent hyperhomocysteinemia in rats." | 5.10 | Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status. ( Feldman, RG; Miller, JW; Nadeau, MR; Selhub, J; Thomas, CA; Wolf, PA, 2003) |
| "Patients with end-stage renal disease are prone to developing a complication of hyperhomocysteinemia, manifesting as an elevation of the homocysteine (Hcy) concentration in human plasma." | 3.96 | Hierarchical Surface Architecture of Hemodialysis Membranes for Eliminating Homocysteine Based on the Multifunctional Role of Pyridoxal 5'-phosphate. ( Chen, L; He, Y; Jiang, P; Zhao, Y, 2020) |
| " Despite association found between PLP deficiency and low antioxidant status in critically ill patients, PLP deficiency was only associated with hyperhomocysteinemia regardless of antioxidant, riboflavin, cobalamine, and folate statuses in critically ill patients with SIRS at seventh day of ICU stay." | 3.83 | Pyridoxal-5'-phosphate deficiency is associated with hyperhomocysteinemia regardless of antioxidant, thiamine, riboflavin, cobalamine, and folate status in critically ill patients. ( de la Cruz, AP; Del Pozo, EP; Florea, D; Molina-López, J; Quintero-Osso, B; Rodríguez-Elvira, M, 2016) |
| "Hyperhomocysteinemia, increased oxidative stress, and decreased antioxidant defense function have been found to be associated with the risk of chronic kidney disease (CKD)." | 3.83 | High homocysteine, low vitamin B-6, and increased oxidative stress are independently associated with the risk of chronic kidney disease. ( Chen, CH; Hsiao, YH; Huang, SC; Huang, YC; Yang, WC, 2016) |
| " Hyperhomocysteinemia is a well-recognized risk factor for cardiovascular disease; however, its association with ST use has never been investigated." | 3.79 | Smokeless tobacco use: a risk factor for hyperhomocysteinemia in a Pakistani population. ( Iqbal, MP; Yakub, M, 2013) |
| "Hyperhomocysteinemia (>15 µmol/L) is highly prevalent in South Asian populations including Pakistan." | 3.78 | Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population. ( Azam, I; Chaudhry, B; Iqbal, MP; Moti, N; Parveen, S; Yakub, M, 2012) |
| "Hyperhomocysteinemia might be at least partially due to compromised B vitamin status in critically ill patients and has been linked with critical illness." | 3.78 | Higher plasma homocysteine is associated with lower vitamin B6 status in critically ill surgical patients. ( Cheng, CH; Hou, CT; Huang, PN; Huang, YC; Wu, YH, 2012) |
| "To research the status of pyridoxal phosphate, folic acid, and cobalamin as part of an examination for hyperhomocysteinemia and to establish their relationship to the results of methionine challenge tests in women, who were tested at least 3 months after they had ended a pregnancy which was complicated by preeclampsia or other vascular-related pregnancy complications." | 3.77 | The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin. ( Bosma, JP; Klip, H; Nooij, LS; van de Leur, JJ; van Eyck, J, 2011) |
| "High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD)." | 3.76 | Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan. ( Iqbal, MP; Yakub, M, 2010) |
| " We found that hyperhomocysteinemia is an independent risk factor (p=0." | 3.75 | Homocysteine level and metabolism in ischemic stroke in the population of Northern Poland. ( Banecka-Majkutewicz, Z; Banecki, B; Jakóbkiewicz-Banecka, J; Kadziński, L; Nyka, W; Sawuła, W; Wegrzyn, G, 2009) |
| "The purpose of this study was to determine if nonsupplementing older women (aged >or=55 years) with rheumatoid arthritis had higher plasma homocysteine and lower B-vitamin status compared to healthy controls." | 3.74 | Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis. ( Manore, MM; Woolf, K, 2008) |
| " We investigated the possible correlation between deficiency of vitamins B6, B12 or folic acid and hyperhomocysteinemia in Pakistani patients with acute myocardial infarction (AMI)." | 3.73 | Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction. ( Ali, SA; Iqbal, MP; Ishaq, M; Kazmi, KA; Khan, AH; Mehboobali, N; Waqar, MA; Yousuf, FA, 2005) |
| "To evaluate the prevalence of moderate fasting hyperhomocysteinemia (HHcy) and postmethionine load (PML) HHcy among patients with early-onset central retinal vein occlusion (CRVO)." | 3.73 | Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion. ( Brancato, R; D'Angelo, A; Fattorini, A; Lattanzio, R; Ramoni, A; Sampietro, F, 2006) |
| "The prevalence of hyperhomocysteinemia (tHcy > 12 micromol/L) was 56%, and 47% had low plasma folate levels (<3 ng/mL)." | 3.70 | Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients. ( Bang, BK; Bostom, AG; Dwyer, JT; Han, H; Jacques, PF; Kim, YS; Park, JH; Selhub, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, P | 1 |
| He, Y | 1 |
| Zhao, Y | 1 |
| Chen, L | 1 |
| To-Figueras, J | 2 |
| Wijngaard, R | 1 |
| García-Villoria, J | 1 |
| Aarsand, AK | 1 |
| Aguilera, P | 1 |
| Deulofeu, R | 2 |
| Brunet, M | 1 |
| Gómez-Gómez, À | 1 |
| Pozo, OJ | 1 |
| Sandberg, S | 1 |
| Iqbal, MP | 4 |
| Yakub, M | 3 |
| Mayengbam, S | 1 |
| Raposo, S | 1 |
| Aliani, M | 1 |
| House, JD | 1 |
| Molina-López, J | 1 |
| Florea, D | 1 |
| Quintero-Osso, B | 1 |
| de la Cruz, AP | 1 |
| Rodríguez-Elvira, M | 1 |
| Del Pozo, EP | 1 |
| Chen, CH | 1 |
| Yang, WC | 1 |
| Hsiao, YH | 1 |
| Huang, SC | 1 |
| Huang, YC | 3 |
| Sawuła, W | 1 |
| Banecka-Majkutewicz, Z | 1 |
| Kadziński, L | 1 |
| Jakóbkiewicz-Banecka, J | 1 |
| Wegrzyn, G | 1 |
| Nyka, W | 1 |
| Banecki, B | 1 |
| Cheng, CH | 2 |
| Tsai, TP | 1 |
| Chen, WS | 1 |
| Lopez, RM | 1 |
| Herrero, C | 1 |
| Nooij, LS | 1 |
| van Eyck, J | 1 |
| Klip, H | 1 |
| van de Leur, JJ | 1 |
| Bosma, JP | 1 |
| Moti, N | 1 |
| Parveen, S | 1 |
| Chaudhry, B | 1 |
| Azam, I | 1 |
| Hou, CT | 1 |
| Wu, YH | 1 |
| Huang, PN | 1 |
| Miller, JW | 1 |
| Selhub, J | 2 |
| Nadeau, MR | 1 |
| Thomas, CA | 1 |
| Feldman, RG | 1 |
| Wolf, PA | 1 |
| Ishaq, M | 1 |
| Kazmi, KA | 1 |
| Yousuf, FA | 1 |
| Mehboobali, N | 1 |
| Ali, SA | 1 |
| Khan, AH | 1 |
| Waqar, MA | 1 |
| Lattanzio, R | 1 |
| Sampietro, F | 1 |
| Ramoni, A | 1 |
| Fattorini, A | 1 |
| Brancato, R | 1 |
| D'Angelo, A | 1 |
| Majchrzak, D | 1 |
| Singer, I | 1 |
| Männer, M | 1 |
| Rust, P | 1 |
| Genser, D | 1 |
| Wagner, KH | 1 |
| Elmadfa, I | 1 |
| Woolf, K | 1 |
| Manore, MM | 1 |
| Han, Q | 1 |
| Lenz, M | 1 |
| Tan, Y | 1 |
| Xu, M | 1 |
| Sun, X | 1 |
| Tan, X | 2 |
| Tang, L | 1 |
| Miljkovic, D | 1 |
| Hoffman, RM | 1 |
| Mansoor, MA | 1 |
| Kristensen, O | 1 |
| Hervig, T | 1 |
| Bates, CJ | 1 |
| Pentieva, K | 1 |
| Vefring, H | 1 |
| Osland, A | 1 |
| Berge, T | 1 |
| Drabløs, PA | 1 |
| Hetland, O | 1 |
| Rolfsen, S | 1 |
| Han, H | 1 |
| Dwyer, JT | 1 |
| Jacques, PF | 1 |
| Park, JH | 1 |
| Kim, YS | 1 |
| Bang, BK | 1 |
| Bostom, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Vitamin Supplementation and Strength Training in Parkinson's Disease[NCT01238926] | 40 participants (Anticipated) | Interventional | 2008-05-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for pyridoxal phosphate and Hyperhomocysteinemia
| Article | Year |
|---|---|
Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status.
Topics: Antiparkinson Agents; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Line | 2003 |
B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans.
Topics: Adult; Aged; Alcohol Drinking; Anthropometry; Aspartate Aminotransferases; Austria; Diet; Diet, Vege | 2006 |
Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate.
Topics: Administration, Oral; Adult; Cholesterol; Cysteine; Dipeptides; Female; Folic Acid; Homocysteine; Hu | 1999 |
18 other studies available for pyridoxal phosphate and Hyperhomocysteinemia
| Article | Year |
|---|---|
Hierarchical Surface Architecture of Hemodialysis Membranes for Eliminating Homocysteine Based on the Multifunctional Role of Pyridoxal 5'-phosphate.
Topics: Cell Adhesion; Cell Proliferation; Coated Materials, Biocompatible; Glycerol; Homocysteine; Human Um | 2020 |
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran.
Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeost | 2021 |
Smokeless tobacco use: a risk factor for hyperhomocysteinemia in a Pakistani population.
Topics: Adolescent; Adult; Cities; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Income; M | 2013 |
Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B₆ deficient rats.
Topics: Animals; Asymptomatic Diseases; Biomarkers; Cystathionine; Cystathionine gamma-Lyase; Diet; Disease | 2015 |
Pyridoxal-5'-phosphate deficiency is associated with hyperhomocysteinemia regardless of antioxidant, thiamine, riboflavin, cobalamine, and folate status in critically ill patients.
Topics: Adult; APACHE; Biomarkers; Cardiovascular Diseases; Critical Illness; Female; Homocysteine; Humans; | 2016 |
High homocysteine, low vitamin B-6, and increased oxidative stress are independently associated with the risk of chronic kidney disease.
Topics: Adult; Aged; Antioxidants; Case-Control Studies; Female; Folic Acid Deficiency; Homocysteine; Humans | 2016 |
Homocysteine level and metabolism in ischemic stroke in the population of Northern Poland.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adolescent; Adult; Aged; Aged, 80 and over; Brain | 2009 |
Serum folate is a reliable indicator of hyperhomocysteinemia and borderline hyperhomocysteinemia in young adults.
Topics: Adolescent; Adult; Area Under Curve; Biomarkers; Cross-Sectional Studies; Erythrocytes; Female; Foli | 2009 |
Preliminary report: hyperhomocysteinemia in patients with acute intermittent porphyria.
Topics: Adult; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Porphyria, Acute Intermi | 2010 |
Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan.
Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocyste | 2010 |
The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Methionine; Pregnanc | 2011 |
Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Cystathionine beta-Syn | 2012 |
Higher plasma homocysteine is associated with lower vitamin B6 status in critically ill surgical patients.
Topics: Aged; Critical Illness; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia | 2012 |
Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction.
Topics: Adult; Aged; Aging; Body Mass Index; Case-Control Studies; Female; Fluorescence Polarization Immunoa | 2005 |
Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Fasting; Female; Folic Acid; Homocysteine; Humans | 2006 |
Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cros | 2008 |
High expression, purification, and properties of recombinant homocysteine alpha, gamma-lyase.
Topics: Animals; Carbon-Sulfur Lyases; Cardiovascular Diseases; Chromatography; Cloning, Molecular; Cysteine | 1998 |
Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients.
Topics: Adult; Aged; Cardiovascular Diseases; Creatinine; Cross-Sectional Studies; Fasting; Female; Folic Ac | 2000 |