pyridoxal phosphate has been researched along with Gyrate Atrophy in 4 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Gyrate Atrophy: Progressive, autosomal recessive, diffuse atrophy of the choroid, pigment epithelium, and sensory retina that begins in childhood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gyrate Atrophy (GA) of the choroid and retina (MIM# 258870) is an autosomal recessive disorder due to mutations of the OAT gene encoding ornithine-delta-aminotransferase (OAT), associated with progressive retinal deterioration and blindness." | 9.12 | Deficit of human ornithine aminotransferase in gyrate atrophy: Molecular, cellular, and clinical aspects. ( Bellezza, I; Borri Voltattorni, C; Cellini, B; Desbats, MA; Montioli, R; Salviati, L, 2021) |
| "Deficit of human ornithine aminotransferase (hOAT), a mitochondrial tetrameric pyridoxal-5'-phosphate (PLP) enzyme, leads to gyrate atrophy of the choroid and retina (GA)." | 8.31 | Biochemical and Bioinformatic Studies of Mutations of Residues at the Monomer-Monomer Interface of Human Ornithine Aminotransferase Leading to Gyrate Atrophy of Choroid and Retina. ( Borri Voltattorni, C; Cellini, B; Floriani, F; Montioli, R, 2023) |
| "Gyrate Atrophy (GA) of the choroid and retina (MIM# 258870) is an autosomal recessive disorder due to mutations of the OAT gene encoding ornithine-delta-aminotransferase (OAT), associated with progressive retinal deterioration and blindness." | 5.12 | Deficit of human ornithine aminotransferase in gyrate atrophy: Molecular, cellular, and clinical aspects. ( Bellezza, I; Borri Voltattorni, C; Cellini, B; Desbats, MA; Montioli, R; Salviati, L, 2021) |
| "Deficit of human ornithine aminotransferase (hOAT), a mitochondrial tetrameric pyridoxal-5'-phosphate (PLP) enzyme, leads to gyrate atrophy of the choroid and retina (GA)." | 4.31 | Biochemical and Bioinformatic Studies of Mutations of Residues at the Monomer-Monomer Interface of Human Ornithine Aminotransferase Leading to Gyrate Atrophy of Choroid and Retina. ( Borri Voltattorni, C; Cellini, B; Floriani, F; Montioli, R, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Floriani, F | 1 |
| Borri Voltattorni, C | 3 |
| Cellini, B | 3 |
| Montioli, R | 3 |
| Bellezza, I | 2 |
| Desbats, MA | 2 |
| Salviati, L | 2 |
| Grottelli, S | 1 |
| Doimo, M | 1 |
| Shah, SA | 1 |
| Shen, BW | 1 |
| Brünger, AT | 1 |
1 review available for pyridoxal phosphate and Gyrate Atrophy
| Article | Year |
|---|---|
Deficit of human ornithine aminotransferase in gyrate atrophy: Molecular, cellular, and clinical aspects.
Topics: Arginine; Choroid; Chromosomes, Human, Pair 10; Coenzymes; Diet; Gene Expression; Gyrate Atrophy; Hu | 2021 |
3 other studies available for pyridoxal phosphate and Gyrate Atrophy
| Article | Year |
|---|---|
Biochemical and Bioinformatic Studies of Mutations of Residues at the Monomer-Monomer Interface of Human Ornithine Aminotransferase Leading to Gyrate Atrophy of Choroid and Retina.
Topics: Atrophy; Choroid; Gyrate Atrophy; Humans; Mutation; Ornithine; Ornithine-Oxo-Acid Transaminase; Pyri | 2023 |
Molecular and cellular basis of ornithine δ-aminotransferase deficiency caused by the V332M mutation associated with gyrate atrophy of the choroid and retina.
Topics: Coenzymes; CRISPR-Cas Systems; Enzyme Assays; Gene Knockout Techniques; Gyrate Atrophy; HEK293 Cells | 2018 |
Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition.
Topics: Aminobutyrates; Arginine; Binding Sites; Crystallography, X-Ray; Cyclohexanecarboxylic Acids; Enzyme | 1997 |