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pyridoxal phosphate and Folic Acid Deficiency

pyridoxal phosphate has been researched along with Folic Acid Deficiency in 15 studies

Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.

Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Research Excerpts

ExcerptRelevanceReference
" We investigated the possible correlation between deficiency of vitamins B6, B12 or folic acid and hyperhomocysteinemia in Pakistani patients with acute myocardial infarction (AMI)."7.73Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction. ( Ali, SA; Iqbal, MP; Ishaq, M; Kazmi, KA; Khan, AH; Mehboobali, N; Waqar, MA; Yousuf, FA, 2005)
"High plasma homocysteine is associated with premature coronary artery disease in men, but the threshold concentration defining this risk and its importance in women and the elderly are unknown."7.69Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. ( Green, R; Gupta, A; Kottke-Marchant, K; Mayer, EL; Miller, DP; Nissen, SE; Robinson, K; Savon, SR; Selhub, J; van Lente, F, 1995)
"Hyperhomocysteinemia, increased oxidative stress, and decreased antioxidant defense function have been found to be associated with the risk of chronic kidney disease (CKD)."3.83High homocysteine, low vitamin B-6, and increased oxidative stress are independently associated with the risk of chronic kidney disease. ( Chen, CH; Hsiao, YH; Huang, SC; Huang, YC; Yang, WC, 2016)
"To research the status of pyridoxal phosphate, folic acid, and cobalamin as part of an examination for hyperhomocysteinemia and to establish their relationship to the results of methionine challenge tests in women, who were tested at least 3 months after they had ended a pregnancy which was complicated by preeclampsia or other vascular-related pregnancy complications."3.77The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin. ( Bosma, JP; Klip, H; Nooij, LS; van de Leur, JJ; van Eyck, J, 2011)
" We investigated the possible correlation between deficiency of vitamins B6, B12 or folic acid and hyperhomocysteinemia in Pakistani patients with acute myocardial infarction (AMI)."3.73Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction. ( Ali, SA; Iqbal, MP; Ishaq, M; Kazmi, KA; Khan, AH; Mehboobali, N; Waqar, MA; Yousuf, FA, 2005)
"High plasma homocysteine is associated with premature coronary artery disease in men, but the threshold concentration defining this risk and its importance in women and the elderly are unknown."3.69Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. ( Green, R; Gupta, A; Kottke-Marchant, K; Mayer, EL; Miller, DP; Nissen, SE; Robinson, K; Savon, SR; Selhub, J; van Lente, F, 1995)
"Body weight was under 90% of the ideal in 8/33 (24%) patients."1.30Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption. ( Camilo, ME; Cardoso, JN; Cravo, M; Glória, L; Leitão, CN; Mira, FC; Oliveira, AG; Resende, M, 1997)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19906 (40.00)18.7374
1990's3 (20.00)18.2507
2000's2 (13.33)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, CH1
Yang, WC1
Hsiao, YH1
Huang, SC1
Huang, YC1
Nooij, LS1
van Eyck, J1
Klip, H1
van de Leur, JJ1
Bosma, JP1
Ye, X1
Lai, CQ1
Crott, JW1
Troen, AM1
Ordovas, JM1
Tucker, KL1
Dill, P1
Schneider, J1
Weber, P1
Trachsel, D1
Tekin, M1
Jakobs, C1
Thöny, B1
Blau, N1
Iqbal, MP1
Ishaq, M1
Kazmi, KA1
Yousuf, FA1
Mehboobali, N1
Ali, SA1
Khan, AH1
Waqar, MA1
Pearl, PL1
Capp, PK1
Novotny, EJ1
Gibson, KM1
Heidemann, E1
Waller, HD1
Robinson, K1
Mayer, EL1
Miller, DP1
Green, R1
van Lente, F1
Gupta, A1
Kottke-Marchant, K1
Savon, SR1
Selhub, J1
Nissen, SE1
Glória, L1
Cravo, M1
Camilo, ME1
Resende, M1
Cardoso, JN1
Oliveira, AG1
Leitão, CN1
Mira, FC1
Pierce, HI1
McGuffin, RG1
Hillman, RS1
Löwik, MR1
van den Berg, H1
Schrijver, J1
Odink, J1
Wedel, M1
van Houten, P1
Ellegaard, J1
Esmann, V1
Hines, JD1
Cowan, DH1
Weintraub, LR1
Weber, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities[NCT01231958]1,650 participants (Actual)Observational2004-06-30Completed
The Effects of Glycine Transport Inhibition on Brain Glycine Concentration[NCT00538070]68 participants (Actual)Interventional2007-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for pyridoxal phosphate and Folic Acid Deficiency

ArticleYear
Inherited disorders of neurotransmitters in children and adults.
    Clinical biochemistry, 2005, Volume: 38, Issue:12

    Topics: Adult; Biopterins; Brain Diseases, Metabolic, Inborn; Child; Folic Acid Deficiency; Humans; Infant,

2005

Other Studies

14 other studies available for pyridoxal phosphate and Folic Acid Deficiency

ArticleYear
High homocysteine, low vitamin B-6, and increased oxidative stress are independently associated with the risk of chronic kidney disease.
    Nutrition (Burbank, Los Angeles County, Calif.), 2016, Volume: 32, Issue:2

    Topics: Adult; Aged; Antioxidants; Case-Control Studies; Female; Folic Acid Deficiency; Homocysteine; Humans

2016
The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin.
    Hypertension in pregnancy, 2011, Volume: 30, Issue:1

    Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Methionine; Pregnanc

2011
The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults.
    Psychosomatic medicine, 2011, Volume: 73, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Boston; Cross-Sectional Stud

2011
Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
    Molecular genetics and metabolism, 2011, Volume: 104, Issue:3

    Topics: Base Sequence; Child; Codon, Nonsense; Congenital Abnormalities; Congenital Microtia; Dihydroxypheny

2011
Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2005, Volume: 15, Issue:2

    Topics: Adult; Aged; Aging; Body Mass Index; Case-Control Studies; Female; Fluorescence Polarization Immunoa

2005
[Disorders of erythropoiesis and the immune system caused by alcohol. 1. Erythropoiesis].
    Fortschritte der Medizin, 1983, Sep-15, Volume: 101, Issue:35

    Topics: Acid Phosphatase; Alcoholism; Anemia; Bone Marrow Cells; Erythrocyte Indices; Erythropoiesis; Female

1983
Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease.
    Circulation, 1995, Nov-15, Volume: 92, Issue:10

    Topics: Age Factors; Aged; Case-Control Studies; Coronary Artery Disease; Female; Folic Acid Deficiency; Hom

1995
Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption.
    The American journal of gastroenterology, 1997, Volume: 92, Issue:3

    Topics: Adult; Alcohol Drinking; Alcoholism; Avitaminosis; Body Height; Body Mass Index; Body Weight; Diet;

1997
Clinical studies in alcoholic sideroblastosis.
    Archives of internal medicine, 1976, Volume: 136, Issue:3

    Topics: Adult; Aged; Alcoholism; Anemia, Sideroblastic; Chronic Disease; Diet; Erythropoiesis; Ethanol; Foli

1976
Marginal nutritional status among institutionalized elderly women as compared to those living more independently (Dutch Nutrition Surveillance System).
    Journal of the American College of Nutrition, 1992, Volume: 11, Issue:6

    Topics: Aged; Ascorbic Acid Deficiency; Calcifediol; Female; Folic Acid Deficiency; Health Status; Homes for

1992
Folate activity of human lymphocytes determined by measurement of serine synthesis.
    Scandinavian journal of clinical and laboratory investigation, 1973, Volume: 31, Issue:1

    Topics: Carbon Dioxide; Carbon Isotopes; Chromatography, Thin Layer; Citric Acid Cycle; Folic Acid; Folic Ac

1973
Studies on the pathogenesis of alcohol-induced sideroblastic bone-marrow abnormalities.
    The New England journal of medicine, 1970, Aug-27, Volume: 283, Issue:9

    Topics: Adult; Alcoholism; Anemia, Sideroblastic; Bone Marrow; Bone Marrow Examination; Erythrocytes; Ethano

1970
The continuing saga of the sideroblast.
    The New England journal of medicine, 1970, Aug-27, Volume: 283, Issue:9

    Topics: Alcoholism; Anemia, Sideroblastic; Bone Marrow; Ethanol; Folic Acid Deficiency; Heme; Humans; Iron;

1970
Report on the International Symposium on Vitamin-related anemias May 27-28, 1968 Skytop (Pennsylvania), U.S.A.
    Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie, 1968, Volume: 38, Issue:3

    Topics: Amino Acids; Anemia; Anemia, Pernicious; Animals; Avitaminosis; Erythropoiesis; Folic Acid Deficienc

1968