pyridoxal phosphate has been researched along with Folic Acid Deficiency in 15 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the possible correlation between deficiency of vitamins B6, B12 or folic acid and hyperhomocysteinemia in Pakistani patients with acute myocardial infarction (AMI)." | 7.73 | Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction. ( Ali, SA; Iqbal, MP; Ishaq, M; Kazmi, KA; Khan, AH; Mehboobali, N; Waqar, MA; Yousuf, FA, 2005) |
| "High plasma homocysteine is associated with premature coronary artery disease in men, but the threshold concentration defining this risk and its importance in women and the elderly are unknown." | 7.69 | Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. ( Green, R; Gupta, A; Kottke-Marchant, K; Mayer, EL; Miller, DP; Nissen, SE; Robinson, K; Savon, SR; Selhub, J; van Lente, F, 1995) |
| "Hyperhomocysteinemia, increased oxidative stress, and decreased antioxidant defense function have been found to be associated with the risk of chronic kidney disease (CKD)." | 3.83 | High homocysteine, low vitamin B-6, and increased oxidative stress are independently associated with the risk of chronic kidney disease. ( Chen, CH; Hsiao, YH; Huang, SC; Huang, YC; Yang, WC, 2016) |
| "To research the status of pyridoxal phosphate, folic acid, and cobalamin as part of an examination for hyperhomocysteinemia and to establish their relationship to the results of methionine challenge tests in women, who were tested at least 3 months after they had ended a pregnancy which was complicated by preeclampsia or other vascular-related pregnancy complications." | 3.77 | The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin. ( Bosma, JP; Klip, H; Nooij, LS; van de Leur, JJ; van Eyck, J, 2011) |
| " We investigated the possible correlation between deficiency of vitamins B6, B12 or folic acid and hyperhomocysteinemia in Pakistani patients with acute myocardial infarction (AMI)." | 3.73 | Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction. ( Ali, SA; Iqbal, MP; Ishaq, M; Kazmi, KA; Khan, AH; Mehboobali, N; Waqar, MA; Yousuf, FA, 2005) |
| "High plasma homocysteine is associated with premature coronary artery disease in men, but the threshold concentration defining this risk and its importance in women and the elderly are unknown." | 3.69 | Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. ( Green, R; Gupta, A; Kottke-Marchant, K; Mayer, EL; Miller, DP; Nissen, SE; Robinson, K; Savon, SR; Selhub, J; van Lente, F, 1995) |
| "Body weight was under 90% of the ideal in 8/33 (24%) patients." | 1.30 | Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption. ( Camilo, ME; Cardoso, JN; Cravo, M; Glória, L; Leitão, CN; Mira, FC; Oliveira, AG; Resende, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CH | 1 |
| Yang, WC | 1 |
| Hsiao, YH | 1 |
| Huang, SC | 1 |
| Huang, YC | 1 |
| Nooij, LS | 1 |
| van Eyck, J | 1 |
| Klip, H | 1 |
| van de Leur, JJ | 1 |
| Bosma, JP | 1 |
| Ye, X | 1 |
| Lai, CQ | 1 |
| Crott, JW | 1 |
| Troen, AM | 1 |
| Ordovas, JM | 1 |
| Tucker, KL | 1 |
| Dill, P | 1 |
| Schneider, J | 1 |
| Weber, P | 1 |
| Trachsel, D | 1 |
| Tekin, M | 1 |
| Jakobs, C | 1 |
| Thöny, B | 1 |
| Blau, N | 1 |
| Iqbal, MP | 1 |
| Ishaq, M | 1 |
| Kazmi, KA | 1 |
| Yousuf, FA | 1 |
| Mehboobali, N | 1 |
| Ali, SA | 1 |
| Khan, AH | 1 |
| Waqar, MA | 1 |
| Pearl, PL | 1 |
| Capp, PK | 1 |
| Novotny, EJ | 1 |
| Gibson, KM | 1 |
| Heidemann, E | 1 |
| Waller, HD | 1 |
| Robinson, K | 1 |
| Mayer, EL | 1 |
| Miller, DP | 1 |
| Green, R | 1 |
| van Lente, F | 1 |
| Gupta, A | 1 |
| Kottke-Marchant, K | 1 |
| Savon, SR | 1 |
| Selhub, J | 1 |
| Nissen, SE | 1 |
| Glória, L | 1 |
| Cravo, M | 1 |
| Camilo, ME | 1 |
| Resende, M | 1 |
| Cardoso, JN | 1 |
| Oliveira, AG | 1 |
| Leitão, CN | 1 |
| Mira, FC | 1 |
| Pierce, HI | 1 |
| McGuffin, RG | 1 |
| Hillman, RS | 1 |
| Löwik, MR | 1 |
| van den Berg, H | 1 |
| Schrijver, J | 1 |
| Odink, J | 1 |
| Wedel, M | 1 |
| van Houten, P | 1 |
| Ellegaard, J | 1 |
| Esmann, V | 1 |
| Hines, JD | 1 |
| Cowan, DH | 1 |
| Weintraub, LR | 1 |
| Weber, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities[NCT01231958] | 1,650 participants (Actual) | Observational | 2004-06-30 | Completed | |||
| The Effects of Glycine Transport Inhibition on Brain Glycine Concentration[NCT00538070] | 68 participants (Actual) | Interventional | 2007-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyridoxal phosphate and Folic Acid Deficiency
| Article | Year |
|---|---|
Inherited disorders of neurotransmitters in children and adults.
Topics: Adult; Biopterins; Brain Diseases, Metabolic, Inborn; Child; Folic Acid Deficiency; Humans; Infant, | 2005 |
14 other studies available for pyridoxal phosphate and Folic Acid Deficiency
| Article | Year |
|---|---|
High homocysteine, low vitamin B-6, and increased oxidative stress are independently associated with the risk of chronic kidney disease.
Topics: Adult; Aged; Antioxidants; Case-Control Studies; Female; Folic Acid Deficiency; Homocysteine; Humans | 2016 |
The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Methionine; Pregnanc | 2011 |
The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Boston; Cross-Sectional Stud | 2011 |
Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
Topics: Base Sequence; Child; Codon, Nonsense; Congenital Abnormalities; Congenital Microtia; Dihydroxypheny | 2011 |
Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction.
Topics: Adult; Aged; Aging; Body Mass Index; Case-Control Studies; Female; Fluorescence Polarization Immunoa | 2005 |
[Disorders of erythropoiesis and the immune system caused by alcohol. 1. Erythropoiesis].
Topics: Acid Phosphatase; Alcoholism; Anemia; Bone Marrow Cells; Erythrocyte Indices; Erythropoiesis; Female | 1983 |
Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease.
Topics: Age Factors; Aged; Case-Control Studies; Coronary Artery Disease; Female; Folic Acid Deficiency; Hom | 1995 |
Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption.
Topics: Adult; Alcohol Drinking; Alcoholism; Avitaminosis; Body Height; Body Mass Index; Body Weight; Diet; | 1997 |
Clinical studies in alcoholic sideroblastosis.
Topics: Adult; Aged; Alcoholism; Anemia, Sideroblastic; Chronic Disease; Diet; Erythropoiesis; Ethanol; Foli | 1976 |
Marginal nutritional status among institutionalized elderly women as compared to those living more independently (Dutch Nutrition Surveillance System).
Topics: Aged; Ascorbic Acid Deficiency; Calcifediol; Female; Folic Acid Deficiency; Health Status; Homes for | 1992 |
Folate activity of human lymphocytes determined by measurement of serine synthesis.
Topics: Carbon Dioxide; Carbon Isotopes; Chromatography, Thin Layer; Citric Acid Cycle; Folic Acid; Folic Ac | 1973 |
Studies on the pathogenesis of alcohol-induced sideroblastic bone-marrow abnormalities.
Topics: Adult; Alcoholism; Anemia, Sideroblastic; Bone Marrow; Bone Marrow Examination; Erythrocytes; Ethano | 1970 |
The continuing saga of the sideroblast.
Topics: Alcoholism; Anemia, Sideroblastic; Bone Marrow; Ethanol; Folic Acid Deficiency; Heme; Humans; Iron; | 1970 |
Report on the International Symposium on Vitamin-related anemias May 27-28, 1968 Skytop (Pennsylvania), U.S.A.
Topics: Amino Acids; Anemia; Anemia, Pernicious; Animals; Avitaminosis; Erythropoiesis; Folic Acid Deficienc | 1968 |