pyridoxal phosphate has been researched along with Disease Models, Animal in 69 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To clarify the basic mechanism involved in the pathophysiology of cystitis by characterizing the urodynamic parameters, pharmacologically relevant (muscarinic and purinergic) receptors, and the in vivo release of adenosine triphosphate (ATP) in the bladder of hydrochloric acid (HCl)-treated rats." | 7.76 | Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. ( Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A, 2010) |
| " In this study, we investigated the effect of the recently developed P2X3 and P2X2/3 receptor antagonist A-317491 on cyclophosphamide (CYP)-induced cystitis to determine whether a P2X receptor antagonist could be beneficial for the treatment of bladder overactivity induced by CYP." | 7.74 | Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats. ( Ikeda, M; Ito, K; Iwami, A; Katsura, H, 2008) |
| "Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat." | 7.69 | Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995) |
| "Cuprizone intoxication is a common animal model used to test myelin regenerative therapies for the treatment of diseases such as multiple sclerosis." | 3.85 | Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation. ( Avila, R; Caporoso, J; Huang, H; Leeper, TC; Manandhar, E; Medicetty, S; Modarelli, DA; Shriver, LP; Taraboletti, A; Walker, T, 2017) |
| " Thiosemicarbazide (TSC) and γ-glutamyl-hydrazone (PLPGH) inhibit the free PLP-dependent isoform (GAD65) activity after systemic administration, leading to epilepsy in mice and in young, but not in adult rats." | 3.81 | Epilepsy and hippocampal neurodegeneration induced by glutamate decarboxylase inhibitors in awake rats. ( Salazar, P; Tapia, R, 2015) |
| "To clarify the basic mechanism involved in the pathophysiology of cystitis by characterizing the urodynamic parameters, pharmacologically relevant (muscarinic and purinergic) receptors, and the in vivo release of adenosine triphosphate (ATP) in the bladder of hydrochloric acid (HCl)-treated rats." | 3.76 | Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. ( Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A, 2010) |
| " In this study, we investigated the effect of the recently developed P2X3 and P2X2/3 receptor antagonist A-317491 on cyclophosphamide (CYP)-induced cystitis to determine whether a P2X receptor antagonist could be beneficial for the treatment of bladder overactivity induced by CYP." | 3.74 | Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats. ( Ikeda, M; Ito, K; Iwami, A; Katsura, H, 2008) |
| " The effect of the P2 antagonists, suramin and PPADS, on the extent of oxygen-induced retinal neovascularization was analyzed." | 3.74 | Involvement of purinergic P2 receptors in experimental retinal neovascularization. ( Croxatto, JO; Gallo, JE; Kvanta, A; Mancini, J; Sarman, S; van der Ploeg, I, 2008) |
| "Elevated concentrations of pipecolic acid have been reported in plasma and CSF of patients with pyridoxine-dependent epilepsy, but its molecular background is unclear." | 3.73 | Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats. ( Hoeger, H; Jakobs, C; Leschnik, M; Muehl, A; Plecko, B; Stoeckler-Ipsiroglu, S; Stromberger, C; Struys, E, 2005) |
| "Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat." | 3.69 | Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995) |
| "It is known that manganese dipyridoxal diphosphate (Mn-DPDP) causes persisting liver enhancement in cholestatic rats, that free Mn++ plus bilirubin induces intrahepatic cholestasis, and that free Mn++ is released in vivo after Mn-DPDP injection." | 3.69 | Effect of manganese dipyridoxal diphosphate on liver magnetic resonance imaging and serum bilirubin in rats with removable biliary obstruction. ( Baert, AL; Grant, D; Gray, TJ; Lukito, G; Marchal, G; Ni, Y; Petré, C, 1995) |
| " Therefore, the present study aimed to trial a modified injection regime using more frequent dosing of BBG to improve outcomes in this model of GVHD." | 1.62 | P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model. ( Adhikary, SR; Casolin, S; Cuthbertson, P; Geraghty, NJ; Sluyter, R; Watson, D, 2021) |
| "Treatment with pyridoxine significantly improved the epileptic phenotype and extended lifespan in plpbp-/- animals." | 1.51 | PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights. ( Abdelrahim, RA; Al Futaisi, A; Al-Shekaili, HH; Al-Thihli, K; Arnold, GL; Ban, K; Begtrup, A; Boon, M; Bosma, M; Boycott, KM; Brimble, E; Bui, T; Cho, MT; Ciapaite, J; Demarest, S; Drögemöller, B; Dyment, DA; Ekker, M; Friedman, JM; Gerkes, EH; Haaxma, CA; Heiner-Fokkema, MR; Houten, SM; Ito, Y; Ivy, AS; Jans, J; Johnstone, DL; Kamsteeg, EJ; Kema, IP; Kernohan, KD; Koolen, DA; Kosuta, C; Koul, R; Lepage, N; Lines, MA; Majewski, J; McBride, S; Noble, S; Olson, H; Pena, IA; Ross, CJ; Roussel, Y; Sigurdardottir, LY; Tarailo-Graovac, M; van Faassen, M; van Karnebeek, CDM; van Roermund, CWT; Verhoeven-Duif, N; Violante, S; Wanders, RJA; Wasserman, WW; Wevers, RA; Wolf, NI, 2019) |
| "Mechanical allodynia was reversed on day 7 in the groups treated with BBG and PPADS." | 1.46 | Blockade of ATP P2X7 receptor enhances ischiatic nerve regeneration in mice following a crush injury. ( Almeida, FM; de Andrade, GM; Marques, SA; Martinez, AMB; Melo, PA; Oliveira, JT; Ribeiro, T; Tomaz, MA, 2017) |
| "Pyridoxine-sensitive seizures characterize severe forms of infantile HPP." | 1.46 | Neuromuscular features of hypophosphatasia. ( Fonta, C; Salles, JP, 2017) |
| "Hydrogen sulfide (H( 2)S) is a biological mediator produced by enzyme-regulated pathways from L-cysteine, which is a substrate for cystathionine-gamma-lyase (CSE)." | 1.36 | L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury. ( Baxter, GF; Elsey, DJ; Fowkes, RC, 2010) |
| "Painful diabetic neuropathy causes hyperalgesia and does not respond to commonly used analgesics such as non-steroidal anti-inflammatory drugs or opioids at doses below those producing disruptive side effects." | 1.35 | Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy. ( Honda, K; Katsuragi, T; Koguchi, M; Migita, K; Moriyama, T; Takano, Y; Ueno, S, 2009) |
| "The PPADS administration decreased both tactile allodynia and thermal hyperalgesia in a time and dose dependent manner." | 1.35 | PPADS, a purinergic antagonist reduces Fos expression at spinal cord level in a mouse model of mononeuropathy. ( Albertini, R; Borsani, E; Colleoni, M; Labanca, M; Lonati, C; Panerai, AE; Rezzani, R; Rodella, LF; Sacerdote, P; Trovato, AE, 2008) |
| " Chronic administration of a nucleotidase-resistant agonist confers a beneficial effect in the CSQ model of heart failure, apparently via an activation of the cardiac P2X receptor." | 1.34 | P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure. ( Cronin, C; Gongora Nieto, M; Harrison, D; Jacobson, KA; Joshi, BV; Liang, BT; Shen, JB; Sonin, D, 2007) |
| "Both heat and mechanical hyperalgesia were observed at the VP ipsilateral to the IoN ligation." | 1.34 | P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain. ( Asai, H; Kawashima, K; Nagamine, K; Ozaki, N; Shinoda, M; Sugiura, Y, 2007) |
| " In the present project, the authors have studied whether MC-1, an analog of PLP, alone or in combination with the thrombolytic agent tissue plasminogen activator (tPA), can protect the brains of rats injured by ischemia." | 1.33 | Role of MC-1 alone and in combination with tissue plasminogen activator in focal ischemic brain injury in rats. ( Noor, R; Shuaib, A; Wang, CX; Yang, T, 2005) |
| "Hypophosphatasia is an inborn error of metabolism characterized by deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and skeletal disease due to impaired mineralization of cartilage and bone matrix." | 1.30 | Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. ( Blair, L; Coburn, SP; Fedde, KN; MacGregor, GR; Millán, JL; Narisawa, S; Ryan, LM; Silverstein, J; Waymire, K; Weinstein, RS; Whyte, MP, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (10.14) | 18.7374 |
| 1990's | 10 (14.49) | 18.2507 |
| 2000's | 29 (42.03) | 29.6817 |
| 2010's | 21 (30.43) | 24.3611 |
| 2020's | 2 (2.90) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, W | 1 |
| Yao, J | 1 |
| Pham, V | 1 |
| Whitney, T | 1 |
| Froese, D | 1 |
| Friesen, A | 1 |
| Stang, L | 1 |
| Xu, C | 1 |
| Shuaib, A | 2 |
| Diakur, JM | 1 |
| Haque, W | 1 |
| Mascolo, E | 1 |
| Liguori, F | 1 |
| Merigliano, C | 1 |
| Schiano, L | 1 |
| Gnocchini, E | 1 |
| Pilesi, E | 1 |
| Volonté, C | 1 |
| Di Salvo, ML | 1 |
| Contestabile, R | 1 |
| Tramonti, A | 1 |
| Vernì, F | 1 |
| Cuthbertson, P | 1 |
| Geraghty, NJ | 1 |
| Adhikary, SR | 1 |
| Casolin, S | 1 |
| Watson, D | 1 |
| Sluyter, R | 1 |
| Ribeiro, T | 1 |
| Oliveira, JT | 1 |
| Almeida, FM | 1 |
| Tomaz, MA | 1 |
| Melo, PA | 1 |
| Marques, SA | 1 |
| de Andrade, GM | 1 |
| Martinez, AMB | 1 |
| Fonta, C | 1 |
| Salles, JP | 1 |
| Johnstone, DL | 1 |
| Al-Shekaili, HH | 1 |
| Tarailo-Graovac, M | 1 |
| Wolf, NI | 1 |
| Ivy, AS | 1 |
| Demarest, S | 1 |
| Roussel, Y | 1 |
| Ciapaite, J | 1 |
| van Roermund, CWT | 1 |
| Kernohan, KD | 1 |
| Kosuta, C | 1 |
| Ban, K | 1 |
| Ito, Y | 1 |
| McBride, S | 1 |
| Al-Thihli, K | 1 |
| Abdelrahim, RA | 1 |
| Koul, R | 1 |
| Al Futaisi, A | 1 |
| Haaxma, CA | 1 |
| Olson, H | 1 |
| Sigurdardottir, LY | 1 |
| Arnold, GL | 1 |
| Gerkes, EH | 1 |
| Boon, M | 1 |
| Heiner-Fokkema, MR | 1 |
| Noble, S | 1 |
| Bosma, M | 1 |
| Jans, J | 1 |
| Koolen, DA | 1 |
| Kamsteeg, EJ | 1 |
| Drögemöller, B | 1 |
| Ross, CJ | 1 |
| Majewski, J | 1 |
| Cho, MT | 1 |
| Begtrup, A | 1 |
| Wasserman, WW | 1 |
| Bui, T | 1 |
| Brimble, E | 1 |
| Violante, S | 1 |
| Houten, SM | 1 |
| Wevers, RA | 1 |
| van Faassen, M | 1 |
| Kema, IP | 1 |
| Lepage, N | 1 |
| Lines, MA | 1 |
| Dyment, DA | 1 |
| Wanders, RJA | 1 |
| Verhoeven-Duif, N | 1 |
| Ekker, M | 1 |
| Boycott, KM | 1 |
| Friedman, JM | 1 |
| Pena, IA | 1 |
| van Karnebeek, CDM | 1 |
| Pereira, VS | 1 |
| Casarotto, PC | 1 |
| Hiroaki-Sato, VA | 1 |
| Sartim, AG | 1 |
| Guimarães, FS | 1 |
| Joca, SR | 1 |
| Hill, CB | 1 |
| Grandgeorge, SH | 1 |
| Bavis, RW | 1 |
| Mayengbam, S | 1 |
| Raposo, S | 1 |
| Aliani, M | 1 |
| House, JD | 1 |
| Kobayashi, D | 1 |
| Yoshimura, T | 1 |
| Johno, A | 1 |
| Ishikawa, M | 1 |
| Sasaki, K | 1 |
| Wada, K | 1 |
| Salazar, P | 1 |
| Tapia, R | 1 |
| Sorolla, MA | 1 |
| Rodríguez-Colman, MJ | 1 |
| Vall-Llaura, N | 1 |
| Vived, C | 1 |
| Fernández-Nogales, M | 1 |
| Lucas, JJ | 1 |
| Ferrer, I | 1 |
| Cabiscol, E | 1 |
| Xiao, J | 1 |
| Huang, Y | 1 |
| Li, X | 1 |
| Li, L | 1 |
| Yang, T | 2 |
| Huang, L | 1 |
| Yang, L | 1 |
| Jiang, H | 1 |
| Li, H | 1 |
| Li, F | 1 |
| Taraboletti, A | 1 |
| Walker, T | 1 |
| Avila, R | 1 |
| Huang, H | 1 |
| Caporoso, J | 1 |
| Manandhar, E | 1 |
| Leeper, TC | 1 |
| Modarelli, DA | 1 |
| Medicetty, S | 1 |
| Shriver, LP | 1 |
| Leng, Y | 1 |
| Yamamoto, T | 1 |
| Kadowaki, M | 1 |
| Franke, H | 1 |
| Sauer, C | 1 |
| Rudolph, C | 1 |
| Krügel, U | 1 |
| Hengstler, JG | 1 |
| Illes, P | 1 |
| Puthussery, T | 1 |
| Fletcher, E | 1 |
| Ni, Y | 3 |
| Wang, H | 2 |
| Chen, F | 1 |
| Li, J | 1 |
| DeKeyzer, F | 1 |
| Feng, Y | 1 |
| Yu, J | 1 |
| Bosmans, H | 1 |
| Marchal, G | 3 |
| Migita, K | 1 |
| Moriyama, T | 1 |
| Koguchi, M | 1 |
| Honda, K | 1 |
| Katsuragi, T | 1 |
| Takano, Y | 1 |
| Ueno, S | 1 |
| Millart, H | 1 |
| Alouane, L | 1 |
| Oszust, F | 1 |
| Chevallier, S | 1 |
| Robinet, A | 1 |
| Dergacheva, O | 1 |
| Kamendi, H | 1 |
| Wang, X | 2 |
| Pinol, RA | 1 |
| Frank, J | 1 |
| Gorini, C | 1 |
| Jameson, H | 1 |
| Lovett-Barr, MR | 1 |
| Mendelowitz, D | 1 |
| Kukulski, F | 1 |
| Ben Yebdri, F | 1 |
| Bahrami, F | 1 |
| Lévesque, SA | 1 |
| Martín-Satué, M | 1 |
| Sévigny, J | 1 |
| Chen, X | 1 |
| Gebhart, GF | 1 |
| Liu, YP | 1 |
| Yang, CS | 1 |
| Chen, MC | 1 |
| Sun, SH | 1 |
| Tzeng, SF | 1 |
| Elsey, DJ | 1 |
| Fowkes, RC | 1 |
| Baxter, GF | 1 |
| Yoshida, A | 1 |
| Kageyama, A | 1 |
| Fujino, T | 1 |
| Nozawa, Y | 1 |
| Yamada, S | 1 |
| Fu, LW | 1 |
| Longhurst, JC | 1 |
| Marcillo, A | 1 |
| Frydel, B | 1 |
| Bramlett, HM | 1 |
| Dietrich, WD | 1 |
| Mezzaroma, E | 1 |
| Toldo, S | 1 |
| Farkas, D | 1 |
| Seropian, IM | 1 |
| Van Tassell, BW | 1 |
| Salloum, FN | 1 |
| Kannan, HR | 1 |
| Menna, AC | 1 |
| Voelkel, NF | 1 |
| Abbate, A | 1 |
| Wenker, IC | 1 |
| Sobrinho, CR | 1 |
| Takakura, AC | 1 |
| Moreira, TS | 1 |
| Mulkey, DK | 1 |
| Shevalye, H | 1 |
| Watcho, P | 1 |
| Stavniichuk, R | 1 |
| Dyukova, E | 1 |
| Lupachyk, S | 1 |
| Obrosova, IG | 1 |
| Tsuda, M | 1 |
| Shigemoto-Mogami, Y | 1 |
| Koizumi, S | 1 |
| Mizokoshi, A | 1 |
| Kohsaka, S | 1 |
| Salter, MW | 1 |
| Inoue, K | 1 |
| Dai, Y | 1 |
| Fukuoka, T | 1 |
| Yamanaka, H | 1 |
| Obata, K | 1 |
| Tokunaga, A | 1 |
| Noguchi, K | 1 |
| Arcuino, G | 1 |
| Takano, T | 1 |
| Lin, J | 1 |
| Peng, WG | 1 |
| Wan, P | 1 |
| Li, P | 1 |
| Xu, Q | 1 |
| Liu, QS | 1 |
| Goldman, SA | 1 |
| Nedergaard, M | 1 |
| Kim, TH | 2 |
| Yang, DH | 2 |
| Choi, JW | 2 |
| Kim, ST | 2 |
| Yoon, JH | 2 |
| Shin, JH | 2 |
| Seo, JB | 2 |
| Gong, GY | 1 |
| Lim, TH | 2 |
| Oliveira, MC | 1 |
| Parada, CA | 1 |
| Veiga, MC | 1 |
| Rodrigues, LR | 1 |
| Barros, SP | 1 |
| Tambeli, CH | 1 |
| Pérez-Rivera, AA | 1 |
| Fink, GD | 1 |
| Galligan, JJ | 1 |
| Wang, CX | 1 |
| Noor, R | 1 |
| Plecko, B | 1 |
| Hoeger, H | 1 |
| Jakobs, C | 1 |
| Struys, E | 1 |
| Stromberger, C | 1 |
| Leschnik, M | 1 |
| Muehl, A | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Kim, DS | 1 |
| Kwak, SE | 1 |
| Kim, JE | 1 |
| Won, MH | 2 |
| Kang, TC | 1 |
| Shen, JB | 1 |
| Cronin, C | 1 |
| Sonin, D | 1 |
| Joshi, BV | 1 |
| Gongora Nieto, M | 1 |
| Harrison, D | 1 |
| Jacobson, KA | 1 |
| Liang, BT | 1 |
| Shinoda, M | 1 |
| Kawashima, K | 1 |
| Ozaki, N | 1 |
| Asai, H | 1 |
| Nagamine, K | 1 |
| Sugiura, Y | 1 |
| Hwang, IK | 1 |
| Yoo, KY | 1 |
| Kim, DH | 1 |
| Lee, BH | 1 |
| Kwon, YG | 1 |
| Ito, K | 1 |
| Iwami, A | 1 |
| Katsura, H | 1 |
| Ikeda, M | 1 |
| Graciano, ML | 1 |
| Nishiyama, A | 1 |
| Jackson, K | 1 |
| Seth, DM | 1 |
| Ortiz, RM | 1 |
| Prieto-Carrasquero, MC | 1 |
| Kobori, H | 1 |
| Navar, LG | 1 |
| Borsani, E | 1 |
| Albertini, R | 1 |
| Colleoni, M | 1 |
| Sacerdote, P | 1 |
| Trovato, AE | 1 |
| Lonati, C | 1 |
| Labanca, M | 1 |
| Panerai, AE | 1 |
| Rezzani, R | 1 |
| Rodella, LF | 1 |
| Sarman, S | 1 |
| Mancini, J | 1 |
| van der Ploeg, I | 1 |
| Croxatto, JO | 1 |
| Kvanta, A | 1 |
| Gallo, JE | 1 |
| Odling-Smee, W | 1 |
| McLarnon, C | 1 |
| Waymire, KG | 1 |
| Mahuren, JD | 1 |
| Jaje, JM | 1 |
| Guilarte, TR | 1 |
| Coburn, SP | 2 |
| MacGregor, GR | 2 |
| Vakulin, GM | 1 |
| Glenn, GM | 1 |
| Krober, MS | 1 |
| Kelly, P | 1 |
| McCarty, J | 1 |
| Weir, M | 1 |
| Grant, D | 2 |
| Toft, KG | 2 |
| Martinsen, I | 1 |
| Atzpodien, E | 1 |
| Karlsson, JO | 2 |
| Mortensen, E | 1 |
| Pedersen, HK | 1 |
| Sager, G | 1 |
| Refsum, H | 2 |
| Petré, C | 1 |
| Lukito, G | 1 |
| Gray, TJ | 1 |
| Baert, AL | 1 |
| Fedde, KN | 1 |
| Blair, L | 1 |
| Silverstein, J | 1 |
| Ryan, LM | 1 |
| Weinstein, RS | 1 |
| Waymire, K | 1 |
| Narisawa, S | 1 |
| Millán, JL | 1 |
| Whyte, MP | 1 |
| Zheng, JH | 1 |
| Chen, J | 1 |
| Bremerich, J | 1 |
| Saeed, M | 1 |
| Arheden, H | 1 |
| Higgins, CB | 1 |
| Wendland, MF | 1 |
| Brurok, H | 1 |
| Eriksen, M | 1 |
| Towart, R | 1 |
| Moen, O | 1 |
| Engebretsen, B | 1 |
| Jynge, P | 1 |
| Wang, XD | 1 |
| Kashii, S | 1 |
| Zhao, L | 1 |
| Tonchev, AB | 1 |
| Katsuki, H | 1 |
| Akaike, A | 1 |
| Honda, Y | 1 |
| Yamashita, J | 1 |
| Yamashima, T | 1 |
| Greenburg, AG | 1 |
| Hayashi, R | 1 |
| Siefert, I | 1 |
| Reese, H | 1 |
| Peskin, GW | 1 |
| Ning, J | 1 |
| Anderson, PJ | 1 |
| Biro, GP | 1 |
| Litvinenko, IuA | 1 |
| Kolonina, IR | 1 |
| Sokolov, AV | 1 |
| Gorbunova, NA | 1 |
| Massé, P | 1 |
| Vuilleumier, JP | 1 |
| Weiser, H | 1 |
| Ryzhov, IV | 1 |
| Lapin, IP | 1 |
| Chung, SH | 1 |
| Caidan, SJ | 1 |
| Norris, DK | 1 |
| Tanaka, M | 1 |
| Bottomley, SS | 1 |
| Dakshinamurti, K | 1 |
| Stephens, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Local Feasibility Study on Mangafodipir as an Adjunct to FOLFOX6 Chemotherapy in Patients Operated Upon Colon Cancer Stage Dukes' C[NCT00671996] | Phase 2 | 14 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Department of Psychiatry, Taichung Veterans General Hospital[NCT04972643] | 163 participants (Actual) | Interventional | 2012-09-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyridoxal phosphate and Disease Models, Animal
| Article | Year |
|---|---|
Clinical implications of studies with MnDPDP in animal models of hepatic abnormalities.
Topics: Animals; Contrast Media; Disease Models, Animal; Drug Evaluation, Preclinical; Edetic Acid; Humans; | 1997 |
[Endogenous convulsants (review)].
Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Diseas | 1986 |
67 other studies available for pyridoxal phosphate and Disease Models, Animal
| Article | Year |
|---|---|
Pyridoxine as a template for the design of antiplatelet agents.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Humans; In Vitro Techniques; Intracranial Thrombosi | 2004 |
Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K.
Topics: Animals; Disease Models, Animal; DNA Damage; Drosophila; Glucose; Humans; Hyperglycemia; Insulin; In | 2022 |
P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model.
Topics: Adult; Animals; B-Lymphocytes; Disease Models, Animal; Female; Graft vs Host Disease; Hematopoietic | 2021 |
Blockade of ATP P2X7 receptor enhances ischiatic nerve regeneration in mice following a crush injury.
Topics: Analgesics; Animals; Crush Injuries; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; | 2017 |
Neuromuscular features of hypophosphatasia.
Topics: Adult; Alkaline Phosphatase; Animals; Biomarkers; Brain Diseases; Chronic Pain; Disease Models, Anim | 2017 |
PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; HEK293 Cells; Humans; Male; Phenotype; Proteins; | 2019 |
Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: involvement of nitric oxide.
Topics: Animals; Antidepressive Agents; Brain; Compulsive Behavior; Depression; Disease Models, Animal; Dose | 2013 |
Developmental hyperoxia alters CNS mechanisms underlying hypoxic ventilatory depression in neonatal rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autonomic Denervation; Central Nervous | 2013 |
Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B₆ deficient rats.
Topics: Animals; Asymptomatic Diseases; Biomarkers; Cystathionine; Cystathionine gamma-Lyase; Diet; Disease | 2015 |
Decrease in pyridoxal-5'-phosphate concentration and increase in pyridoxal concentration in rat plasma by 4'-O-methylpyridoxine administration.
Topics: Animals; Brain; Disease Models, Animal; Foodborne Diseases; gamma-Aminobutyric Acid; Ginkgo biloba; | 2015 |
Epilepsy and hippocampal neurodegeneration induced by glutamate decarboxylase inhibitors in awake rats.
Topics: Amino Acids; Animals; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2015 |
Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice.
Topics: Adult; Aged; Animals; Cerebral Cortex; Corpus Striatum; Cystathionine; Disease Models, Animal; Disea | 2016 |
TNP-ATP is Beneficial for Treatment of Neonatal Hypoxia-Induced Hypomyelination and Cognitive Decline.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Cognition Disorders; Disease Models, Anima | 2016 |
Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Cell Line; Chelating Agents; Copper; Cuprizone; Demyel | 2017 |
Alteration of cholinergic, purinergic and sensory neurotransmission in the mouse colon of food allergy model.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Chemokine CCL2; Colon; Disease Models, Animal; Electric | 2008 |
P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo.
Topics: Adenosine Diphosphate; Androstadienes; Animals; Apoptosis; Astrocytes; Brain Injuries; Disease Model | 2009 |
Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Survival; Disease Models, Animal; Extracellular Spa | 2009 |
Tumor models and specific contrast agents for small animal imaging in oncology.
Topics: Animals; Biomarkers, Tumor; Clinical Trials as Topic; Contrast Media; Diagnostic Imaging; Disease Mo | 2009 |
Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mod | 2009 |
Involvement of P2Y receptors in pyridoxal-5'-phosphate-induced cardiac preconditioning.
Topics: Animals; Creatine Kinase; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Male; Myocar | 2009 |
5-HT2 receptors modulate excitatory neurotransmission to cardiac vagal neurons within the nucleus ambiguus evoked during and after hypoxia.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Heart; Hypoxia, Brain; Ketanser | 2009 |
The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production.
Topics: Animals; Apyrase; Cell Movement; Chemokine CXCL2; Chemokines; Disease Models, Animal; Exudates and T | 2010 |
Differential purinergic signaling in bladder sensory neurons of naïve and bladder-inflamed mice.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Cyclophosphamide; Disease Models, Animal; Dogs; Ga | 2010 |
Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Benzoxazoles; Calcium; | 2010 |
L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury.
Topics: Alkynes; Analysis of Variance; Animals; Cysteine; Disease Models, Animal; Drug Therapy, Combination; | 2010 |
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
Topics: Adenosine Triphosphate; Animals; Benzhydryl Compounds; Benzofurans; Cresols; Cystitis; Disease Model | 2010 |
A new function for ATP: activating cardiac sympathetic afferents during myocardial ischemia.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic Fibers; Animals; Cats; | 2010 |
A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury.
Topics: Animals; Contusions; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Neuroprotective A | 2012 |
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; CARD Signaling Adaptor Protein | 2011 |
Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Blood Pressure; Brain Stem; Calcium; Carbenoxolo | 2012 |
Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Folic Acid; Hyper | 2012 |
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Male; Microgli | 2003 |
Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons.
Topics: Adenosine Triphosphate; Animals; Cell Count; Disease Models, Animal; Dose-Response Relationship, Dru | 2004 |
P2X7 receptor inhibition improves recovery after spinal cord injury.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Benzoxazines; Disease Models, Animal; Electrophysiology; | 2004 |
Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part I: comparison with pathologic examination.
Topics: Acute Disease; Animals; Cats; Contrast Media; Disease Models, Animal; Edetic Acid; Magnetic Resonanc | 2005 |
Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part II: comparison with cine magnetic resonance imaging.
Topics: Acute Disease; Animals; Cats; Contrast Media; Disease Models, Animal; Edetic Acid; Magnetic Resonanc | 2005 |
Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis; Carrageenan; Disea | 2005 |
Alpha-1B adrenoceptors mediate neurogenic constriction in mesenteric arteries of normotensive and DOCA-salt hypertensive mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; D | 2005 |
Role of MC-1 alone and in combination with tissue plasminogen activator in focal ischemic brain injury in rats.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Dose-R | 2005 |
Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Brain; Disease Models, Animal; Epilepsy; Female | 2005 |
The co-treatments of vigabatrin and P2X receptor antagonists protect ischemic neuronal cell death in the gerbil hippocampus.
Topics: Adenosine Triphosphatases; Animals; Cell Death; Disease Models, Animal; Drug Therapy, Combination; E | 2006 |
P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Benzenesulfonates; Ca | 2007 |
P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain.
Topics: Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalges | 2007 |
Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Animals; Astrocytes; Brain Infarction; Brain | 2007 |
Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats.
Topics: Animals; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Femal | 2008 |
Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension.
Topics: Actins; Adenosine Triphosphate; Angiotensin II; Animals; Arterioles; Blood Pressure; Cell Proliferat | 2008 |
PPADS, a purinergic antagonist reduces Fos expression at spinal cord level in a mouse model of mononeuropathy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Involvement of purinergic P2 receptors in experimental retinal neovascularization.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Mice; M | 2008 |
Haemoglobin solution as an oxygen-carrying resuscitation fluid in haemorrhagic shock.
Topics: Animals; Blood Pressure; Dextrans; Disease Models, Animal; Dogs; Hemoglobins; Humans; Oxygen; Pyrido | 1984 |
Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.
Topics: Alkaline Phosphatase; Animals; Brain Chemistry; Calcification, Physiologic; Disease Models, Animal; | 1995 |
[The morphological criteria of a decrease in the permeability and trophism of the cirrhotically altered liver in rats and of their increase under the influence of pyrogenal and pyridoxal phosphate (morphometry, transmission and scanning electron microscop
Topics: Animals; Carbon Tetrachloride Poisoning; Cell Membrane Permeability; Disease Models, Animal; Drug Ev | 1993 |
Pyridoxine as therapy in theophylline-induced seizures.
Topics: Aminophylline; Animals; Bronchodilator Agents; Disease Models, Animal; Electroencephalography; Femal | 1995 |
Tissue distribution and general safety of MnDPDP in male beagle dogs, with or without total common bile duct obstruction.
Topics: Animals; Cholestasis, Extrahepatic; Common Bile Duct; Contrast Media; Disease Models, Animal; Dogs; | 1997 |
Cardiovascular effects of MnDPDP and MnCl2 in dogs with acute ischaemic heart failure.
Topics: Acute Disease; Animals; Cardiovascular System; Chlorides; Contrast Media; Depression, Chemical; Dise | 1997 |
Effect of manganese dipyridoxal diphosphate on liver magnetic resonance imaging and serum bilirubin in rats with removable biliary obstruction.
Topics: Animals; Bilirubin; Cholestasis; Contrast Media; Disease Models, Animal; Edetic Acid; Liver; Magneti | 1995 |
Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia.
Topics: Age Factors; Alkaline Phosphatase; Animals; Animals, Newborn; Body Weight; Disease Models, Animal; H | 1999 |
Modulatory roles of the adenosine triphosphate P2x-purinoceptor in generation of the persistent nociception induced by subcutaneous bee venom injection in the conscious rat.
Topics: Adenosine Triphosphate; Analgesics; Animals; Bee Venoms; Consciousness; Disease Models, Animal; Hind | 2000 |
Normal and infarcted myocardium: differentiation with cellular uptake of manganese at MR imaging in a rat model.
Topics: Analysis of Variance; Animals; Contrast Media; Coronary Disease; Disease Models, Animal; Dose-Respon | 2000 |
Cardioprotective effects of the MR contrast agent MnDPDP and its metabolite MnPLED upon reperfusion of the ischemic porcine myocardium.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Contrast Media; Coronary Circulation; Disease Models, A | 2001 |
Vitamin B6 protects primate retinal neurons from ischemic injury.
Topics: Animals; Disease Models, Animal; Disease Progression; Ischemic Attack, Transient; Macaca; Neurons; O | 2002 |
Intravascular persistence and oxygen delivery of pyridoxalated, stroma-free hemoglobin during gradations of hypotension.
Topics: Animals; Blood; Blood Pressure; Blood Volume; Disease Models, Animal; Dogs; Female; Half-Life; Hemog | 1979 |
Resuscitation of bled dogs with pyridoxalated-polymerized hemoglobin solution.
Topics: Animals; Blood Substitutes; Disease Models, Animal; Dogs; Hemodynamics; Hemoglobins; Kidney; Male; P | 1992 |
[Study of the effectiveness of artificial oxygen carrier on the hemoglobin base in blood loss replacement in dogs].
Topics: Acute Disease; Animals; Blood Substitutes; Bloodletting; Disease Models, Animal; Dogs; Drug Carriers | 1991 |
Pyridoxine status as assessed by the concentration of B6-aldehyde vitamers.
Topics: Animals; Chickens; Diet; Disease Models, Animal; Erythrocytes; Male; Pyridoxal Phosphate; Vitamin B | 1989 |
Enhancement of brain pyridoxal 5'-phosphate level following chronic ingestion of ethanol.
Topics: Alcoholism; Animals; Behavior, Animal; Brain Chemistry; Disease Models, Animal; Ethanol; Female; Flu | 1985 |
Bone marrow delta-aminolevulinic acid synthetase activity in experimental sideroblastic anemia.
Topics: 5-Aminolevulinate Synthetase; Anemia, Sideroblastic; Animals; Bone Marrow; Bone Marrow Cells; Cyclos | 1974 |
Pyridoxine deficiency in the neonatal rat.
Topics: Age Factors; Alanine Transaminase; Animals; Animals, Newborn; Aspartate Aminotransferases; Body Weig | 1969 |