pyridoxal phosphate has been researched along with Diabetes Mellitus, Type 1 in 7 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sera obtained from Japanese SPIDDM (n = 17) and AIDDM (n = 46) patients followed prospectively were analyzed by immunoprecipitation, ELISA, and Western blotting." | 1.32 | Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes. ( Kobayashi, T; Lernmark, A; Murase, T; Nakanishi, K; Okubo, M; Tanaka, S, 2003) |
| "GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease." | 1.31 | Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding. ( Falorni, A; Hammerle, LP; Hampe, CS; Lernmark, A; Robertson, J, 2001) |
| "Of 45 type 1 diabetes sera tested, 30 (67%) had an 80% or greater reduction of reactivity to GAD65(delta258-270) vs." | 1.31 | The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera. ( Mackay, IR; Myers, MA; Rowley, MJ; Tong, JC; Zimmet, PZ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rubí, B | 1 |
| Massé, PG | 1 |
| Boudreau, J | 1 |
| Tranchant, CC | 1 |
| Ouellette, R | 1 |
| Ericson, KL | 1 |
| Kobayashi, T | 1 |
| Tanaka, S | 1 |
| Okubo, M | 1 |
| Nakanishi, K | 1 |
| Murase, T | 1 |
| Lernmark, A | 2 |
| Sköldberg, F | 1 |
| Rorsman, F | 1 |
| Perheentupa, J | 1 |
| Landin-Olsson, M | 1 |
| Husebye, ES | 1 |
| Gustafsson, J | 1 |
| Kämpe, O | 1 |
| Myers, MA | 2 |
| Davies, JM | 1 |
| Tong, JC | 2 |
| Whisstock, J | 1 |
| Scealy, M | 1 |
| Mackay, IR | 2 |
| Rowley, MJ | 2 |
| Hampe, CS | 1 |
| Hammerle, LP | 1 |
| Falorni, A | 1 |
| Robertson, J | 1 |
| Zimmet, PZ | 1 |
7 other studies available for pyridoxal phosphate and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Pyridoxal 5'-phosphate (PLP) deficiency might contribute to the onset of type I diabetes.
Topics: Autoimmunity; Diabetes Mellitus, Type 1; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; I | 2012 |
Type 1 diabetes impairs vitamin B(6) metabolism at an early stage of women's adulthood.
Topics: Adult; Age Factors; Alkaline Phosphatase; Biomarkers; Case-Control Studies; Chi-Square Distribution; | 2012 |
Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes.
Topics: Autoantibodies; Binding Sites; Diabetes Mellitus, Type 1; Enzyme-Linked Immunosorbent Assay; Epitope | 2003 |
Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease.
Topics: Addison Disease; Aromatic-L-Amino-Acid Decarboxylases; Autoantibodies; Carboxy-Lyases; Cross Reactio | 2004 |
Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigen-Antibody Reactions; Autoantigens; Binding Sites | 2000 |
Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Autoantibodies; Autoantigens; Binding Sites; | 2001 |
The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera.
Topics: Amino Acid Sequence; Amino Acid Substitution; B-Lymphocytes; Diabetes Mellitus, Type 1; Epitopes, B- | 2002 |