pyridoxal phosphate has been researched along with Cryptogenic Infantile Spasms in 17 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 7.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| " Although several studies have reported serious adverse events following PLP treatment, no study has investigated the risk factors for such occurrences." | 5.91 | Identifying risk factors for adverse events of pyridoxal phosphate in infantile epileptic spasms syndrome. ( Arai, Y; Kanai, S; Maegaki, Y; Noma, H; Ohta, K; Okanishi, T; Sunada, H, 2023) |
| "We report a 2-month-old male with West syndrome associated with infantile hypophosphatasia." | 5.32 | A successful treatment with pyridoxal phosphate for West syndrome in hypophosphatasia. ( Kamiyama, N; Miyamoto, Y; Murakami, H; Sasamoto, Y; Yamamoto, H, 2004) |
| "To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations." | 3.80 | Pyridoxine responsiveness in novel mutations of the PNPO gene. ( Abela, L; Clayton, P; Connolly, M; Hasselmann, O; Hofer, D; Kanz, S; Maier, O; Mills, P; Paschke, E; Paul, K; Plecko, B; Schmiedel, G; Stockler, S; Struys, E; Wolf, N, 2014) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 3.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| "Eighteen children with West syndrome (5-11 months of age) were selected to receive an oral dose of pyridoxal phosphate, (20-50 mg/kg) for 14 d." | 2.69 | Cerebrospinal fluid somatostatin in West syndrome: changes in response to combined treatment with high-dose pyridoxal phosphate and low-dose corticotropin. ( Hirai, K; Seki, T; Takuma, Y, 1998) |
| " Although several studies have reported serious adverse events following PLP treatment, no study has investigated the risk factors for such occurrences." | 1.91 | Identifying risk factors for adverse events of pyridoxal phosphate in infantile epileptic spasms syndrome. ( Arai, Y; Kanai, S; Maegaki, Y; Noma, H; Ohta, K; Okanishi, T; Sunada, H, 2023) |
| "We report a 2-month-old male with West syndrome associated with infantile hypophosphatasia." | 1.32 | A successful treatment with pyridoxal phosphate for West syndrome in hypophosphatasia. ( Kamiyama, N; Miyamoto, Y; Murakami, H; Sasamoto, Y; Yamamoto, H, 2004) |
| " The good response to a small dosage of ACTH might be due to some responsiveness of the high-dose pyridoxal phosphate and the underlying cause of tuberous sclerosis with normal development before onset." | 1.30 | A case of West syndrome well controlled by very short and low-dose ACTH therapy. ( Kimura, M; Miyamoto, S; Sejima, H; Yamaguchi, S, 1999) |
| "1) Only one of 27 children with West syndrome and related disorders pretreated using high-dose PAL-P alone before ACTH showed a clinically excellent response." | 1.28 | Combination treatment of high-dose pyridoxal phosphate and low-dose ACTH in children with West syndrome and related disorders. ( Seki, T, 1990) |
| "Fifteen (12." | 1.27 | Treatment of the West syndrome with high-dose pyridoxal phosphate. ( Kobayashi, K; Matsuda, M; Ogino, T; Ohtahara, S; Ohtsuka, Y, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Gowda, VK | 1 |
| Srinivasan, VM | 1 |
| Arai, Y | 1 |
| Okanishi, T | 1 |
| Kanai, S | 1 |
| Ohta, K | 1 |
| Sunada, H | 1 |
| Noma, H | 1 |
| Maegaki, Y | 1 |
| Plecko, B | 2 |
| Paul, K | 1 |
| Mills, P | 1 |
| Clayton, P | 1 |
| Paschke, E | 1 |
| Maier, O | 1 |
| Hasselmann, O | 1 |
| Schmiedel, G | 1 |
| Kanz, S | 1 |
| Connolly, M | 1 |
| Wolf, N | 1 |
| Struys, E | 2 |
| Stockler, S | 1 |
| Abela, L | 2 |
| Hofer, D | 1 |
| Mathis, D | 1 |
| Albersen, M | 1 |
| Bürer, C | 1 |
| Crowther, L | 1 |
| Beese, K | 1 |
| Hartmann, H | 1 |
| Bok, LA | 1 |
| Papuc, SM | 1 |
| Rauch, A | 1 |
| Hersberger, M | 1 |
| Verhoeven-Duif, NM | 1 |
| Yamamoto, H | 2 |
| Sasamoto, Y | 1 |
| Miyamoto, Y | 2 |
| Murakami, H | 2 |
| Kamiyama, N | 2 |
| Wang, HS | 2 |
| Kuo, MF | 2 |
| Chou, ML | 1 |
| Hung, PC | 1 |
| Lin, KL | 1 |
| Hsieh, MY | 1 |
| Chang, MY | 1 |
| Fukuda, M | 1 |
| Ohtsuka, Y | 2 |
| Yamatogi, Y | 2 |
| Yoshida, H | 1 |
| Matsuda, M | 2 |
| Iyoda, K | 2 |
| Terasaki, T | 2 |
| Oka, E | 1 |
| Ohtahara, S | 3 |
| Takuma, Y | 3 |
| Seki, T | 4 |
| Hirai, K | 1 |
| Kimura, M | 1 |
| Miyamoto, S | 1 |
| Sejima, H | 1 |
| Yamaguchi, S | 1 |
| Miyake, S | 1 |
| Narusawa, K | 1 |
| Ogino, T | 1 |
| Kobayashi, K | 1 |
1 review available for pyridoxal phosphate and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
[Treatment of West syndrome: present and future perspectives].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Humans; Infant; Pilot Projects; Pyridoxal Phosphate; S | 1997 |
2 trials available for pyridoxal phosphate and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
ACTH therapy for infantile spasms: a combination therapy with high-dose pyridoxal phosphate and low-dose ACTH.
Topics: Age of Onset; Anticonvulsants; Child, Preschool; Cosyntropin; Drug Administration Schedule; Drug The | 1998 |
Cerebrospinal fluid somatostatin in West syndrome: changes in response to combined treatment with high-dose pyridoxal phosphate and low-dose corticotropin.
Topics: Adrenocorticotropic Hormone; Aging; Anti-Inflammatory Agents; Female; Humans; Infant; Male; Pyridoxa | 1998 |
14 other studies available for pyridoxal phosphate and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Ohtahara and West Syndrome due to Pyridox(am)ine-5-Phosphate Oxidase (PNPO) Deficiency with Novel Phenotype and Good Outcome without Pyridoxal-5'-Phosphate.
Topics: Humans; Metabolic Diseases; Oxidoreductases; Phenotype; Phosphates; Pyridoxal Phosphate; Spasms, Inf | 2023 |
Identifying risk factors for adverse events of pyridoxal phosphate in infantile epileptic spasms syndrome.
Topics: Humans; Infant; Pyridoxal Phosphate; Retrospective Studies; Risk Factors; Spasm; Spasms, Infantile; | 2023 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Aldehyde Dehydrogenase; Alleles; Animals; Brain Diseases, Metabolic; CHO Cells; Chromosome Deletion; | 2014 |
The value of plasma vitamin B6 profiles in early onset epileptic encephalopathies.
Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Mal | 2016 |
A successful treatment with pyridoxal phosphate for West syndrome in hypophosphatasia.
Topics: Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electroencephalography; Fata | 2004 |
Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Sche | 2005 |
A case of Pallister-Killian syndrome associated with West syndrome.
Topics: Anticonvulsants; Humans; Infant; Isochromosomes; Male; Mosaicism; Pyridoxal Phosphate; Spasms, Infan | 2007 |
[High-dose pyridoxal phosphate in the treatment of the West and the Lennox syndromes].
Topics: Child; Child, Preschool; Female; Humans; Infant; Male; Pyridoxal Phosphate; Spasms, Infantile | 1983 |
Combination therapy of infantile spasms with high-dose pyridoxal phosphate and low-dose corticotropin.
Topics: Adrenocorticotropic Hormone; Age of Onset; Anticonvulsants; Drug Therapy, Combination; Electroenceph | 1996 |
A case of West syndrome well controlled by very short and low-dose ACTH therapy.
Topics: Adrenocorticotropic Hormone; Electroencephalography; Humans; Infant; Male; Pyridoxal Phosphate; Spas | 1999 |
Pyridoxal phosphate-responsive epilepsy with resistance to pyridoxine.
Topics: Administration, Oral; Electroencephalography; Female; Humans; Infant, Newborn; Infant, Premature, Di | 2002 |
Combination treatment of high-dose pyridoxal phosphate and low-dose ACTH in children with West syndrome and related disorders.
Topics: Child, Preschool; Cosyntropin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug | 1990 |
[A long-term follow-up study on a case with glycine encephalopathy].
Topics: Amino Acid Metabolism, Inborn Errors; Brain Diseases, Metabolic; Child, Preschool; Diazepam; Electro | 1988 |
Treatment of the West syndrome with high-dose pyridoxal phosphate.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Electroencephalography; Follow-Up Studies | 1987 |