pyridoxal phosphate has been researched along with Coronary Disease in 19 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In plasma from 3035 patients undergoing coronary angiography for suspected coronary heart disease, we investigated if plasma concentrations of any metabolites in the kynurenine pathway, which depend on PLP as cofactor, may serve as metabolic marker(s) of vitamin B-6 status." | 7.77 | Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. ( Bleie, O; Ebbing, M; Midttun, O; Nilsen, RM; Nygård, O; Ringdal Pedersen, E; Schartum-Hansen, H; Ueland, PM; Ulvik, A, 2011) |
| "To test the hypothesis that endogenous synthesis of taurine from methionine is impaired in people with coronary heart disease (CHD)." | 7.72 | Plasma taurine and cysteine levels following an oral methionine load: relationship with coronary heart disease. ( Emery, PW; Johnston, K; Obeid, OA, 2004) |
| "Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD)." | 7.70 | Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. ( Davis, CE; Eckfeldt, JH; Folsom, AR; Hess, DL; Malinow, MR; McGovern, PG; Nieto, FJ; Tsai, MY, 1998) |
| " In plasma from 3035 patients undergoing coronary angiography for suspected coronary heart disease, we investigated if plasma concentrations of any metabolites in the kynurenine pathway, which depend on PLP as cofactor, may serve as metabolic marker(s) of vitamin B-6 status." | 3.77 | Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. ( Bleie, O; Ebbing, M; Midttun, O; Nilsen, RM; Nygård, O; Ringdal Pedersen, E; Schartum-Hansen, H; Ueland, PM; Ulvik, A, 2011) |
| "To test the hypothesis that endogenous synthesis of taurine from methionine is impaired in people with coronary heart disease (CHD)." | 3.72 | Plasma taurine and cysteine levels following an oral methionine load: relationship with coronary heart disease. ( Emery, PW; Johnston, K; Obeid, OA, 2004) |
| "Tryptophan load test followed by serum kynurenine determination at fasting state and after L-tryptophan loading, as well as serum pyridoxal-5-phosphate (P-5-P), homocysteine and neopterin concentrations at fasting state have been examined in 30 healthy individuals and 87 patients with coronary heart disease (CHD), verified by coronary angiography." | 3.72 | Prognostic value of tryptophan load test followed by serum kynurenine determination. Its comparison with pyridoxal-5-phosphate, kynurenine, homocysteine and neopterin amounts. ( Erglis, A; Fuchs, D; Jegere, S; Jurika, E; Kalnins, U; Rudzite, V; Silava, A; Trusinskis, K, 2003) |
| "Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD)." | 3.70 | Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. ( Davis, CE; Eckfeldt, JH; Folsom, AR; Hess, DL; Malinow, MR; McGovern, PG; Nieto, FJ; Tsai, MY, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Midttun, O | 1 |
| Ulvik, A | 1 |
| Ringdal Pedersen, E | 1 |
| Ebbing, M | 1 |
| Bleie, O | 1 |
| Schartum-Hansen, H | 1 |
| Nilsen, RM | 1 |
| Nygård, O | 1 |
| Ueland, PM | 1 |
| Kandzari, DE | 1 |
| Labinaz, M | 1 |
| Cantor, WJ | 1 |
| Madan, M | 1 |
| Gallup, DS | 1 |
| Hasselblad, V | 2 |
| Joseph, D | 1 |
| Allen, A | 1 |
| Green, C | 1 |
| Hidinger, KG | 1 |
| Krucoff, MW | 1 |
| Christenson, RH | 1 |
| Harrington, RA | 2 |
| Tcheng, JE | 1 |
| Obeid, OA | 1 |
| Johnston, K | 1 |
| Emery, PW | 1 |
| Rudzite, V | 2 |
| Fuchs, D | 1 |
| Kalnins, U | 1 |
| Jurika, E | 2 |
| Silava, A | 1 |
| Erglis, A | 1 |
| Trusinskis, K | 1 |
| Jegere, S | 1 |
| Reynolds, RD | 1 |
| Leklem, JE | 1 |
| Gergs, U | 1 |
| Boknik, P | 1 |
| Schmitz, W | 1 |
| Simm, A | 1 |
| Silber, RE | 1 |
| Neumann, J | 1 |
| Mehta, RH | 1 |
| Alexander, JH | 1 |
| Emery, R | 1 |
| Ellis, SJ | 1 |
| Khalil, A | 1 |
| Carrier, M | 1 |
| Tardif, JC | 1 |
| Dalery, K | 1 |
| Lussier-Cacan, S | 1 |
| Selhub, J | 1 |
| Davignon, J | 1 |
| Latour, Y | 1 |
| Genest, J | 1 |
| Folsom, AR | 1 |
| Nieto, FJ | 1 |
| McGovern, PG | 1 |
| Tsai, MY | 1 |
| Malinow, MR | 1 |
| Eckfeldt, JH | 1 |
| Hess, DL | 1 |
| Davis, CE | 1 |
| Bremerich, J | 1 |
| Saeed, M | 2 |
| Arheden, H | 1 |
| Higgins, CB | 3 |
| Wendland, MF | 2 |
| Miller, JW | 1 |
| Green, R | 1 |
| Mungas, DM | 1 |
| Reed, BR | 1 |
| Jagust, WJ | 1 |
| Pomeroy, OH | 1 |
| Wendland, M | 1 |
| Wagner, S | 1 |
| Derugin, N | 1 |
| Holt, WW | 1 |
| Rocklage, SM | 1 |
| Quay, S | 1 |
| Jirgensons, J | 1 |
| Sileniece, G | 1 |
| Zirne, R | 1 |
| Jirgensone, S | 1 |
| Vermaak, WJ | 2 |
| Barnard, HC | 2 |
| Potgieter, GM | 2 |
| Marx, JD | 1 |
| Theron, HD | 1 |
| Serfontein, WJ | 2 |
| Ubbink, JB | 2 |
| De Villiers, LS | 2 |
| Becker, PJ | 2 |
| Rossouw, JE | 1 |
| Labadarios, D | 1 |
| Jooste, PL | 1 |
| Shephard, GS | 1 |
| Rapley, CH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Double Blind Study of the Effects of Homocysteine Lowering Therapy on Mortality and Cardiac Events in Patients Undergoing Coronary Angiography[NCT00354081] | Phase 3 | 3,096 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| MEND-CABG II: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG Surgery[NCT00402506] | Phase 3 | 3,000 participants (Anticipated) | Interventional | 2006-11-30 | Completed | ||
| Folic Acid Clinical Trial (FACT): Biomarker Subgroup Analysis[NCT03981029] | 51 participants (Actual) | Observational | 2011-12-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for pyridoxal phosphate and Coronary Disease
| Article | Year |
|---|---|
Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial).
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiotonic Agents; Coronary Angiography; Coronary Disease; Do | 2003 |
A randomized, double-blind, placebo-controlled, multicenter study to evaluate the cardioprotective effects of MC-1 in patients undergoing high-risk coronary artery bypass graft surgery: MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft
Topics: Cardiovascular Diseases; Coronary Artery Bypass; Coronary Disease; Double-Blind Method; Humans; Myoc | 2008 |
17 other studies available for pyridoxal phosphate and Coronary Disease
| Article | Year |
|---|---|
Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation.
Topics: Adult; Aged; C-Reactive Protein; Coronary Disease; Female; Humans; Inflammation; Kynurenine; Male; M | 2011 |
Plasma taurine and cysteine levels following an oral methionine load: relationship with coronary heart disease.
Topics: Adult; Case-Control Studies; Coronary Disease; Cysteine; Europe; Fasting; Humans; India; Male; Methi | 2004 |
Prognostic value of tryptophan load test followed by serum kynurenine determination. Its comparison with pyridoxal-5-phosphate, kynurenine, homocysteine and neopterin amounts.
Topics: Biomarkers; Case-Control Studies; Coronary Disease; Homocysteine; Humans; Kynurenine; Neopterin; Pro | 2003 |
Vitamin B-6 status and coronary artery disease.
Topics: Alkaline Phosphatase; Coronary Disease; Humans; Pyridoxal Phosphate; Risk Factors; Smoking; Vitamin | 2004 |
A positive inotropic effect of ATP in the human cardiac atrium.
Topics: Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyc | 2008 |
Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate.
Topics: Adult; Chi-Square Distribution; Coronary Disease; Discriminant Analysis; Female; Folic Acid; France; | 1995 |
Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.
Topics: Arteriosclerosis; Cohort Studies; Coronary Disease; Dietary Supplements; Fasting; Female; Folic Acid | 1998 |
Normal and infarcted myocardium: differentiation with cellular uptake of manganese at MR imaging in a rat model.
Topics: Analysis of Variance; Animals; Contrast Media; Coronary Disease; Disease Models, Animal; Dose-Respon | 2000 |
Homocysteine, vitamin B6, and vascular disease in AD patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Angina Pectoris; Brain Infarction; Coronary Disease; Fem | 2002 |
Magnetic resonance contrast media for myocardial imaging.
Topics: Animals; Contrast Media; Coronary Disease; Dysprosium; Gadolinium; Gadolinium DTPA; Magnetic Resonan | 1990 |
Magnetic resonance imaging of acute myocardial ischemia using a manganese chelate, Mn-DPDP.
Topics: Animals; Blood Pressure; Contrast Media; Coronary Circulation; Coronary Disease; Edetic Acid; In Vit | 1989 |
[Peculiarities of nicotinic acid formation in coronary heart disease with special reference to heart arrhythmias].
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Coronary Disease; Female; Humans; Kynurenine; Lipid | 1988 |
Plasma pyridoxal-5'-phosphate levels in myocardial infarction.
Topics: Cholesterol, HDL; Chronic Disease; Coronary Disease; Fasting; Humans; Middle Aged; Myocardial Infarc | 1986 |
Vitamin B6 and coronary artery disease. Epidemiological observations and case studies.
Topics: Adult; Black or African American; Black People; Cholesterol; Cholesterol, HDL; Coronary Disease; Fem | 1987 |
Depressed plasma pyridoxal-5'-phosphate levels in tobacco-smoking men.
Topics: Adult; Age Factors; Arteriosclerosis; Coronary Disease; Humans; Male; Middle Aged; Pyridoxal; Pyrido | 1986 |
Lack of a relationship between plasma pyridoxal phosphate levels and ischaemic heart disease.
Topics: Coronary Disease; Humans; Male; Middle Aged; Pyridoxal Phosphate; Rural Population; South Africa | 1985 |
Plasma pyridoxal-5-phosphate level as risk index for coronary artery disease.
Topics: Cholesterol; Cholesterol, HDL; Chromatography, High Pressure Liquid; Coronary Disease; Humans; Male; | 1985 |