pyridoxal phosphate has been researched along with Colorectal Cancer in 25 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous epidemiological studies have focused on the association of dietary vitamin B6 or circulating pyridoxal-5′-phosphate (PLP) with colorectal cancer risk." | 8.12 | Association of Serum Pyridoxal-5'-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study. ( Abulimiti, A; Che, MM; Fang, YJ; Huang, CY; Xu, L; Zhang, CX, 2022) |
| "Increased homocysteine was strongly associated with the risk of colorectal cancer independently of oxidative stress indicators and antioxidant capacities." | 7.80 | High homocysteine is associated with increased risk of colorectal cancer independently of oxidative stress and antioxidant capacities. ( Chiang, FF; Huang, SC; Huang, YC; Lan, YC; Wang, HM; Yang, MH, 2014) |
| "Previous epidemiological studies have focused on the association of dietary vitamin B6 or circulating pyridoxal-5′-phosphate (PLP) with colorectal cancer risk." | 4.12 | Association of Serum Pyridoxal-5'-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study. ( Abulimiti, A; Che, MM; Fang, YJ; Huang, CY; Xu, L; Zhang, CX, 2022) |
| "Increased homocysteine was strongly associated with the risk of colorectal cancer independently of oxidative stress indicators and antioxidant capacities." | 3.80 | High homocysteine is associated with increased risk of colorectal cancer independently of oxidative stress and antioxidant capacities. ( Chiang, FF; Huang, SC; Huang, YC; Lan, YC; Wang, HM; Yang, MH, 2014) |
| "The pooled RRs of colorectal cancer for the highest vs lowest category of vitamin B(6) intake and blood PLP levels were 0." | 2.46 | Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. ( Larsson, SC; Orsini, N; Wolk, A, 2010) |
| "Vitamin B(6) may lower risk of colorectal cancer by preventing aberrations in one-carbon metabolism or by anti-inflammatory effects." | 1.35 | Prospective study of plasma vitamin B6 and risk of colorectal cancer in men. ( Giovannucci, E; Lee, IM; Lee, JE; Li, H; Ma, J; Selhub, J; Stampfer, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holowatyj, AN | 1 |
| Ose, J | 1 |
| Gigic, B | 1 |
| Lin, T | 1 |
| Ulvik, A | 3 |
| Geijsen, AJMR | 1 |
| Brezina, S | 1 |
| Kiblawi, R | 1 |
| van Roekel, EH | 1 |
| Baierl, A | 1 |
| Böhm, J | 1 |
| Bours, MJL | 1 |
| Brenner, H | 1 |
| Breukink, SO | 1 |
| Chang-Claude, J | 1 |
| de Wilt, JHW | 1 |
| Grady, WM | 1 |
| Grünberger, T | 1 |
| Gumpenberger, T | 1 |
| Herpel, E | 1 |
| Hoffmeister, M | 1 |
| Keulen, ETP | 1 |
| Kok, DE | 1 |
| Koole, JL | 1 |
| Kosma, K | 1 |
| Kouwenhoven, EA | 1 |
| Kvalheim, G | 1 |
| Li, CI | 1 |
| Schirmacher, P | 1 |
| Schrotz-King, P | 1 |
| Singer, MC | 1 |
| van Duijnhoven, FJB | 1 |
| van Halteren, HK | 1 |
| Vickers, K | 1 |
| Vogelaar, FJ | 1 |
| Warby, CA | 1 |
| Wesselink, E | 1 |
| Ueland, PM | 3 |
| Ulrich, AB | 1 |
| Schneider, M | 1 |
| Habermann, N | 1 |
| Kampman, E | 1 |
| Weijenberg, MP | 1 |
| Gsur, A | 1 |
| Ulrich, CM | 1 |
| Xu, L | 1 |
| Fang, YJ | 1 |
| Che, MM | 1 |
| Abulimiti, A | 1 |
| Huang, CY | 1 |
| Zhang, CX | 1 |
| Gylling, B | 2 |
| Myte, R | 2 |
| Midttun, Ø | 1 |
| Schneede, J | 2 |
| Hallmans, G | 2 |
| Häggström, J | 2 |
| Johansson, I | 2 |
| Van Guelpen, B | 2 |
| Palmqvist, R | 2 |
| Nan, H | 1 |
| Giovannucci, EL | 1 |
| Wu, K | 1 |
| Selhub, J | 3 |
| Paul, L | 1 |
| Rosner, B | 1 |
| Fuchs, CS | 2 |
| Cho, E | 1 |
| Chiang, FF | 2 |
| Wang, HM | 2 |
| Lan, YC | 1 |
| Yang, MH | 1 |
| Huang, SC | 2 |
| Huang, YC | 2 |
| Coriat, R | 1 |
| Alexandre, J | 1 |
| Nicco, C | 1 |
| Quinquis, L | 1 |
| Benoit, E | 1 |
| Chéreau, C | 1 |
| Lemaréchal, H | 1 |
| Mir, O | 1 |
| Borderie, D | 1 |
| Tréluyer, JM | 1 |
| Weill, B | 1 |
| Coste, J | 1 |
| Goldwasser, F | 1 |
| Batteux, F | 1 |
| Karlsson, JO | 1 |
| Ignarro, LJ | 1 |
| Lundström, I | 1 |
| Jynge, P | 1 |
| Almén, T | 1 |
| Chen, FP | 1 |
| Lee, JE | 1 |
| Li, H | 1 |
| Giovannucci, E | 2 |
| Lee, IM | 1 |
| Stampfer, M | 1 |
| Ma, J | 2 |
| Larsson, SC | 1 |
| Orsini, N | 1 |
| Wolk, A | 1 |
| Kulemann, V | 1 |
| Schima, W | 1 |
| Tamandl, D | 1 |
| Kaczirek, K | 1 |
| Gruenberger, T | 1 |
| Wrba, F | 1 |
| Weber, M | 1 |
| Ba-Ssalamah, A | 1 |
| Lu, CC | 1 |
| Leung, EY | 1 |
| Roxburgh, CS | 1 |
| Talwar, D | 1 |
| O'Reilly, DS | 1 |
| McKee, RF | 1 |
| Horgan, PG | 1 |
| McMillan, DC | 1 |
| Bartolozzi, C | 1 |
| Donati, F | 1 |
| Cioni, D | 1 |
| Procacci, C | 1 |
| Morana, G | 1 |
| Chiesa, A | 1 |
| Grazioli, L | 1 |
| Cittadini, G | 2 |
| Giovagnoni, A | 1 |
| Gandini, G | 1 |
| Maass, J | 1 |
| Lencioni, R | 1 |
| Kim, KW | 2 |
| Kim, AY | 1 |
| Kim, TK | 1 |
| Park, SH | 1 |
| Kim, HJ | 2 |
| Lee, YK | 1 |
| Park, MS | 1 |
| Ha, HK | 1 |
| Kim, PN | 2 |
| Kim, JC | 1 |
| Lee, MG | 2 |
| Beziat, C | 1 |
| Pilleul, F | 1 |
| Yzebe, D | 1 |
| Lombard-Bohas, C | 1 |
| Mercier, C | 1 |
| Valette, PJ | 1 |
| Wei, EK | 1 |
| Hankinson, SE | 1 |
| Regge, D | 1 |
| Campanella, D | 1 |
| Anselmetti, GC | 1 |
| Cirillo, S | 1 |
| Gallo, TM | 1 |
| Muratore, A | 1 |
| Capussotti, L | 1 |
| Galatola, G | 1 |
| Floriani, I | 1 |
| Aglietta, M | 1 |
| Byun, JH | 1 |
| Won, HJ | 1 |
| Shin, YM | 1 |
| Lee, MS | 1 |
| Koh, DM | 3 |
| Brown, G | 3 |
| Meer, Z | 1 |
| Norman, AR | 1 |
| Husband, JE | 2 |
| Bryant, M | 1 |
| Higginson, A | 1 |
| Riddell, AM | 1 |
| Scurr, E | 1 |
| Collins, DJ | 1 |
| Allen, SD | 1 |
| Chau, I | 1 |
| Cunningham, D | 2 |
| deSouza, NM | 1 |
| Leach, MO | 1 |
| Kong, G | 1 |
| Jackson, C | 1 |
| Lewington, V | 1 |
| Sharma, B | 1 |
| Cook, GJ | 1 |
| Helmberger, TK | 1 |
| Laubenberger, J | 1 |
| Rummeny, E | 1 |
| Jung, G | 1 |
| Sievers, K | 1 |
| Döhring, W | 1 |
| Meurer, K | 1 |
| Reiser, MF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Mangafodipir Protective Activity Against Oxaliplatin Neurotoxicity[NCT00727922] | Phase 2 | 23 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyridoxal phosphate and Colorectal Cancer
| Article | Year |
|---|---|
Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biological Mimicry; Colorectal Neoplasms; Edetic Acid; | 2015 |
Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cohort Studies; Colorectal Neoplasms; Diet; Fe | 2010 |
6 trials available for pyridoxal phosphate and Colorectal Cancer
| Article | Year |
|---|---|
Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir.
Topics: Action Potentials; Administration, Intravenous; Aged; Animals; Antineoplastic Agents; Antioxidants; | 2014 |
Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT.
Topics: Adult; Aged; Colorectal Neoplasms; Contrast Media; Edetic Acid; Female; Humans; Liver Neoplasms; Mag | 2004 |
[Detection of liver metastases in colorectal cancer on chemotherapy. Comparative study between MRI with teslascan and computed tomography with intravenous contrast media].
Topics: Aged; Colorectal Neoplasms; Contrast Media; Edetic Acid; Feasibility Studies; Humans; Injections; Io | 2004 |
Comparison of mangafodipir trisodium- and ferucarbotran-enhanced MRI for detection and characterization of hepatic metastases in colorectal cancer patients.
Topics: Adult; Aged; Colorectal Neoplasms; Contrast Media; Dextrans; Edetic Acid; Female; Ferrosoferric Oxid | 2006 |
Diagnostic accuracy of rim and segmental MRI enhancement of colorectal hepatic metastasis after administration of mangafodipir trisodium.
Topics: Adult; Aged; Colorectal Neoplasms; Contrast Media; Edetic Acid; Female; Humans; Image Enhancement; L | 2007 |
MRI characteristics in focal hepatic disease before and after administration of MnDPDP: discriminant analysis as a diagnostic tool.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Contrast | 2002 |
17 other studies available for pyridoxal phosphate and Colorectal Cancer
| Article | Year |
|---|---|
Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.
Topics: Biomarkers; Carbon; Colorectal Neoplasms; Folic Acid; Humans; Neoplasm Recurrence, Local; Prospectiv | 2022 |
Association of Serum Pyridoxal-5'-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study.
Topics: Case-Control Studies; Colorectal Neoplasms; Humans; Male; Pyridoxal; Pyridoxal Phosphate; Pyridoxic | 2022 |
One-carbon metabolite ratios as functional B-vitamin markers and in relation to colorectal cancer risk.
Topics: Betaine; Biomarkers, Tumor; Carbon; Case-Control Studies; Colorectal Neoplasms; Creatinine; Cysteine | 2019 |
Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women.
Topics: Adenocarcinoma; Adult; Case-Control Studies; Colorectal Neoplasms; Cysteine; DNA Methylation; DNA, N | 2013 |
High homocysteine is associated with increased risk of colorectal cancer independently of oxidative stress and antioxidant capacities.
Topics: Adult; Aged; Antioxidants; Blood Pressure; Body Mass Index; Case-Control Studies; Colorectal Neoplas | 2014 |
High serum folate might have a potential dual effect on risk of colorectal cancer.
Topics: Adult; Aged; Body Mass Index; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Homocy | 2015 |
Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Colorectal Neoplasms; Female; Humans; Inflammation; K | 2017 |
Prospective study of plasma vitamin B6 and risk of colorectal cancer in men.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; C-Reactive Protein; Case-Control Studies; Colorectal Neopla | 2009 |
Preoperative detection of colorectal liver metastases in fatty liver: MDCT or MRI?
Topics: Aged; Colorectal Neoplasms; Contrast Media; Dextrans; Edetic Acid; Fatty Liver; Female; Gadolinium D | 2011 |
Vitamin B6, blood PLP level, and risk of colorectal cancer.
Topics: Colorectal Neoplasms; Humans; Pyridoxal Phosphate; Vitamin B 6 | 2010 |
The relationships between plasma and red cell vitamin B2 and B6 concentrations and the systemic and local inflammatory responses in patients with colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Colorectal Neoplasms; Erythrocytes; Female; Flav | 2012 |
Small (
Topics: Adult; Aged; Colorectal Neoplasms; Contrast Media; Edetic Acid; Female; Humans; Liver; Liver Neoplas | 2004 |
Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women.
Topics: Adenoma; Adult; Aged; Case-Control Studies; Colorectal Neoplasms; Confidence Intervals; Female; Huma | 2005 |
Diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Contrast Media; Edetic Acid; Female; Humans; L | 2006 |
Re: diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma.
Topics: Colorectal Neoplasms; Contrast Media; Edetic Acid; Female; Humans; Magnetic Resonance Imaging; Male; | 2007 |
Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination.
Topics: Aged; Colorectal Neoplasms; Contrast Media; Diffusion Magnetic Resonance Imaging; Edetic Acid; Femal | 2008 |
The use of 18F-FDG PET/CT in colorectal liver metastases--comparison with CT and liver MRI.
Topics: Aged; Colorectal Neoplasms; Contrast Media; Edetic Acid; False Positive Reactions; Female; Fluorodeo | 2008 |