pyridoxal phosphate has been researched along with Carcinoma, Hepatocellular in 40 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to study the effects of serum folate and plasma pyridoxal 5'-phosphate (PLP) on plasma homocysteine, oxidative stress and antioxidant capacities in 44 hepatocellular carcinoma (HCC) patients and 56 healthy controls." | 7.83 | Folate and vitamin B-6 status are not associated with homocysteine, oxidative stress and antioxidant capacities in patients with hepatocellular carcinoma. ( Cheng, SB; Huang, YC; Lai, CY; Lin, PT; Liu, HT, 2016) |
| "To determine the efficacy of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP) at magnetic resonance (MR) imaging for evaluation of hepatocellular carcinoma (HCC)." | 5.08 | Hepatocellular carcinoma: MR imaging with mangafodipir trisodium (Mn-DPDP). ( Baron, RL; Confer, SR; Davis, PL; Federle, MP; Murakami, T; Oliver, JH; Peterson, MS, 1996) |
| "The purpose of this study was to study the effects of serum folate and plasma pyridoxal 5'-phosphate (PLP) on plasma homocysteine, oxidative stress and antioxidant capacities in 44 hepatocellular carcinoma (HCC) patients and 56 healthy controls." | 3.83 | Folate and vitamin B-6 status are not associated with homocysteine, oxidative stress and antioxidant capacities in patients with hepatocellular carcinoma. ( Cheng, SB; Huang, YC; Lai, CY; Lin, PT; Liu, HT, 2016) |
| "Rats fed diets deficient in choline develop hepatocellular carcinoma." | 3.79 | Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma. ( Arning, E; Bottiglieri, T; Butler, LM; Gao, YT; Govindarajan, S; Wang, R; Yuan, JM, 2013) |
| "Twenty-one patients with 39 hepatocellular carcinomas underwent ferumoxides-enhanced and mangafodipir trisodium-enhanced MR imaging." | 2.70 | Preoperative detection of hepatocellular carcinoma: ferumoxides-enhanced versus mangafodipir trisodium-enhanced MR imaging. ( Choi, D; Kim, H; Kim, SH; Kim, SK; Lee, SJ; Lee, WJ; Lim, HK; Lim, JH; Seo, JW, 2002) |
| "Fifty patients with liver cirrhosis and histologically proven HCC were enrolled in a prospective phase-IIIB clinical trial." | 2.69 | MnDPDP-enhanced MRI vs dual-phase spiral CT in the detection of hepatocellular carcinoma in cirrhosis. ( Bartolozzi, C; Cioni, D; Crocetti, L; Donati, F; Lencioni, R, 2000) |
| "Intrahepatic thrombus is usually associated with either cirrhosis or hepatocellular carcinoma (HCC)." | 2.68 | Tumoural portal vein thrombosis. Enhancement with MnDPDP. ( Anglade, MC; Coffin, C; Lonjedo, E; Marti-Bonmati, L; Mathieu, D; Poyatos, C, 1997) |
| "We used cultured human hepatoma cells and evaluated static intracellular profiles of amino acids and in vivo kinetics of H2S biomarker formation." | 1.40 | Vitamin B-6 restriction reduces the production of hydrogen sulfide and its biomarkers by the transsulfuration pathway in cultured human hepatoma cells. ( Banerjee, R; Chi, YY; DeRatt, BN; Gregory, JF; Kabil, O; Ralat, MA, 2014) |
| "Hypotonicity triggered in human hepatoma cells (Huh-7) the release of ATP and cell swelling, followed by volume regulatory decrease (RVD)." | 1.39 | On the role of ATP release, ectoATPase activity, and extracellular ADP in the regulatory volume decrease of Huh-7 human hepatoma cells. ( Alberti, GS; Alvarez, CL; Davio, C; de Tezanos Pinto, F; Espelt, MV; Incicco, J; Leal Denis, MF; Schwarzbaum, PJ, 2013) |
| "The lesions in hepatocellular carcinomas patients showed a non-homogeneous enhancement pattern." | 1.33 | Characterization of focal liver lesions: use of mangafodipir trisodium (MnDPDP)-enhanced MR images. ( Adigüzel, Y; Haykir, R; Karabacakoğlu, A; Karaköse, S; Kayaçetin, E, 2006) |
| "Forty-six patients with 96 hepatocellular carcinomas underwent Mn-DPDP- and gadopentetate dimeglumine-enhanced MRI." | 1.32 | MRI for detection of hepatocellular carcinoma: comparison of mangafodipir trisodium and gadopentetate dimeglumine contrast agents. ( Kim, CS; Lee, JM; Youk, JH, 2004) |
| "These two cases had hepatocellular carcinoma and fibrolamellar hepatocellular carcinoma, respectively, confirmed on liver biopsy." | 1.31 | Technical report: lymph node enhancement at MRI with MnDPDP in primary hepatic carcinoma. ( Burkill, GJ; Healy, JC; Mannion, EM, 2001) |
| "A total of 69 primary and secondary liver cancers from these three animal models were studied." | 1.29 | Experimental liver cancers: Mn-DPDP-enhanced rims in MR-microangiographic-histologic correlation study. ( Baert, AL; Lodemann, KP; Marchal, G; Ni, Y; Rummeny, E; Yu, J; Zhang, X, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (22.50) | 18.7374 |
| 1990's | 11 (27.50) | 18.2507 |
| 2000's | 15 (37.50) | 29.6817 |
| 2010's | 5 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Espelt, MV | 1 |
| de Tezanos Pinto, F | 1 |
| Alvarez, CL | 1 |
| Alberti, GS | 1 |
| Incicco, J | 1 |
| Leal Denis, MF | 1 |
| Davio, C | 1 |
| Schwarzbaum, PJ | 1 |
| Butler, LM | 1 |
| Arning, E | 1 |
| Wang, R | 1 |
| Bottiglieri, T | 1 |
| Govindarajan, S | 1 |
| Gao, YT | 1 |
| Yuan, JM | 1 |
| DeRatt, BN | 1 |
| Ralat, MA | 2 |
| Kabil, O | 1 |
| Chi, YY | 1 |
| Banerjee, R | 1 |
| Gregory, JF | 2 |
| Cheng, SB | 1 |
| Liu, HT | 1 |
| Lin, PT | 1 |
| Lai, CY | 1 |
| Huang, YC | 1 |
| Kim, JH | 1 |
| Kim, MJ | 2 |
| Park, YN | 1 |
| Lee, JT | 1 |
| Kim, BR | 1 |
| Chung, JB | 1 |
| Choi, JS | 1 |
| Kim, KS | 1 |
| Kim, KW | 2 |
| Zhao, M | 1 |
| da Silva, V | 1 |
| Garrett, TJ | 1 |
| Melnyk, S | 1 |
| James, SJ | 1 |
| Kim, SK | 1 |
| Kim, SH | 1 |
| Lee, WJ | 1 |
| Kim, H | 1 |
| Seo, JW | 1 |
| Choi, D | 1 |
| Lim, HK | 1 |
| Lee, SJ | 1 |
| Lim, JH | 1 |
| Wang, DB | 1 |
| Zhou, KR | 1 |
| Zeng, MS | 1 |
| Chen, KM | 1 |
| Wang, YX | 1 |
| Guo, T | 1 |
| Zhang, XL | 1 |
| Chang, RM | 1 |
| Zhang, YZ | 1 |
| ITO, K | 2 |
| NAKAHARA, I | 2 |
| SAKAMOTO, Y | 2 |
| Bedda, S | 1 |
| Laurent, A | 1 |
| Conti, F | 1 |
| Chéreau, C | 1 |
| Tran, A | 1 |
| Tran-Van Nhieu, J | 1 |
| Jaffray, P | 1 |
| Soubrane, O | 1 |
| Goulvestre, C | 1 |
| Calmus, Y | 1 |
| Weill, B | 1 |
| Batteux, F | 1 |
| Savellano, DH | 1 |
| Köstler, H | 1 |
| Baus, S | 1 |
| Mössinger, M | 1 |
| Gratz, KF | 1 |
| Weimann, A | 1 |
| Galanski, M | 1 |
| Youk, JH | 1 |
| Lee, JM | 1 |
| Kim, CS | 1 |
| Chung, JJ | 1 |
| Karabacakoğlu, A | 1 |
| Adigüzel, Y | 1 |
| Karaköse, S | 1 |
| Kayaçetin, E | 1 |
| Haykir, R | 1 |
| Liou, J | 1 |
| Lee, JK | 2 |
| Borrello, JA | 1 |
| Brown, JJ | 1 |
| Ni, Y | 1 |
| Marchal, G | 1 |
| Yu, J | 1 |
| Rummeny, E | 2 |
| Zhang, X | 1 |
| Lodemann, KP | 1 |
| Baert, AL | 1 |
| Rofsky, NM | 1 |
| Weinreb, JC | 1 |
| Bernardino, ME | 1 |
| Young, SW | 1 |
| Noz, ME | 1 |
| Murakami, T | 1 |
| Baron, RL | 1 |
| Peterson, MS | 1 |
| Oliver, JH | 1 |
| Davis, PL | 1 |
| Confer, SR | 1 |
| Federle, MP | 1 |
| Chezmar, JL | 1 |
| Redvanly, RD | 1 |
| Sewell, CW | 1 |
| Padovani, B | 1 |
| Lecesne, R | 1 |
| Raffaelli, C | 1 |
| Chevallier, P | 1 |
| Drouillard, J | 1 |
| Bruneton, JN | 1 |
| Lambrechts, M | 1 |
| Gordon, P | 1 |
| Kettritz, U | 1 |
| Schlund, JF | 1 |
| Wilbur, K | 1 |
| Eisenberg, LB | 1 |
| Semelka, RC | 1 |
| Marti-Bonmati, L | 1 |
| Lonjedo, E | 1 |
| Mathieu, D | 2 |
| Coffin, C | 1 |
| Poyatos, C | 1 |
| Anglade, MC | 1 |
| Wang, C | 1 |
| Coffin, CM | 1 |
| Diche, T | 1 |
| Mahfouz, A | 1 |
| Alexandre, M | 1 |
| Caseiro-Alves, F | 1 |
| Rahmouni, A | 1 |
| Vasile, N | 1 |
| Bartolozzi, C | 1 |
| Donati, F | 1 |
| Cioni, D | 1 |
| Crocetti, L | 1 |
| Lencioni, R | 1 |
| Burkill, GJ | 1 |
| Mannion, EM | 1 |
| Healy, JC | 1 |
| Grimm, J | 1 |
| Müller-Hülsbeck, S | 1 |
| Blume, J | 1 |
| Biederer, J | 1 |
| Heller, M | 1 |
| Iciek, MB | 1 |
| Rokita, HB | 1 |
| Wlodek, LB | 1 |
| Helmberger, TK | 1 |
| Laubenberger, J | 1 |
| Jung, G | 1 |
| Sievers, K | 1 |
| Döhring, W | 1 |
| Meurer, K | 1 |
| Reiser, MF | 1 |
| Seltzer, SE | 1 |
| Getty, DJ | 1 |
| Pickett, RM | 1 |
| Swets, JA | 1 |
| Sica, G | 1 |
| Brown, J | 1 |
| Saini, S | 1 |
| Mattrey, RF | 1 |
| Harmon, B | 1 |
| Francis, IR | 1 |
| Chezmar, J | 1 |
| Schnall, MO | 1 |
| Siegelman, ES | 1 |
| Ballerini, R | 1 |
| Bhat, S | 1 |
| Hamm, B | 1 |
| Vogl, TJ | 1 |
| Branding, G | 1 |
| Schnell, B | 1 |
| Taupitz, M | 1 |
| Wolf, KJ | 1 |
| Lissner, J | 1 |
| Zaman, SN | 1 |
| Tredger, JM | 1 |
| Johnson, PJ | 1 |
| Williams, R | 1 |
| Herzfeld, A | 1 |
| Knox, WE | 1 |
| Bukin, IuV | 1 |
| Sergeev, AV | 1 |
| Raushenbakh, MO | 1 |
| Hosoda, S | 1 |
| Nakamura, W | 1 |
| Snell, KC | 1 |
| Stewart, HL | 1 |
| Grigo, KM | 1 |
| Von Redlich, D | 1 |
| Glick, D | 1 |
| Goriukhina, TA | 1 |
| Lebedeva, SB | 1 |
| Harik, SI | 1 |
| Hollenberg, MD | 1 |
| Snyder, SH | 1 |
13 trials available for pyridoxal phosphate and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Preoperative detection of hepatocellular carcinoma: ferumoxides-enhanced versus mangafodipir trisodium-enhanced MR imaging.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Contrast Media; Dextrans; Edetic Acid; False Negative Reacti | 2002 |
Mangafodipir trisodium-enhanced MRI for the detection and characterization of focal hepatic lesions: is delayed imaging useful?
Topics: Adult; Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cholangiocarc | 2006 |
Hepatocellular tumors: characterization with Mn-DPDP-enhanced MR imaging.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Contrast Media; Diagnosis, Differential; | 1993 |
Hepatocellular carcinoma: MR imaging with mangafodipir trisodium (Mn-DPDP).
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Confidence Intervals; Contrast Media; Ede | 1996 |
Uptake of mangafodipir trisodium (MnDPDP) by hepatocellular carcinoma: correlation with unenhanced imaging findings and histopathologic features.
Topics: Adult; Biopsy; Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Humans; Image Enhancement; Li | 1996 |
Tolerability and utility of mangafodipir trisodium injection (MnDPDP) at the dose of 5 mumol/kg body weight in detecting focal liver tumors: results of a phase III trial using an infusion technique.
Topics: Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Female; Humans; Infusions, Intravenous; Live | 1996 |
Tumoural portal vein thrombosis. Enhancement with MnDPDP.
Topics: Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Female; Humans; Liv | 1997 |
Benign and malignant hepatocellular tumors: evaluation of tumoral enhancement after mangafodipir trisodium injection on MR imaging.
Topics: Adenoma, Liver Cell; Adult; Aged; Biopsy, Needle; Carcinoma, Hepatocellular; Contrast Media; Diagnos | 1999 |
MnDPDP-enhanced MRI vs dual-phase spiral CT in the detection of hepatocellular carcinoma in cirrhosis.
Topics: Carcinoma, Hepatocellular; Edetic Acid; Female; Follow-Up Studies; Humans; Iodized Oil; Liver Cirrho | 2000 |
[Comparison of biphasic spiral CT and MnDPDP-enhanced MRI in the detection and characterization of liver lesions].
Topics: Adenoma; Adult; Aged; Biopsy; Carcinoma, Hepatocellular; Cholangiocarcinoma; Cysts; Diagnosis, Diffe | 2001 |
MRI characteristics in focal hepatic disease before and after administration of MnDPDP: discriminant analysis as a diagnostic tool.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Contrast | 2002 |
Multimodality diagnosis of liver tumors: feature analysis with CT, liver-specific and contrast-enhanced MR, and a computer model.
Topics: Adult; Carcinoma, Hepatocellular; Computer Simulation; Contrast Media; Edetic Acid; Humans; Liver Ne | 2002 |
Focal liver lesions: MR imaging with Mn-DPDP--initial clinical results in 40 patients.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Evaluation Studies as Topic; Fe | 1992 |
27 other studies available for pyridoxal phosphate and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
On the role of ATP release, ectoATPase activity, and extracellular ADP in the regulatory volume decrease of Huh-7 human hepatoma cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Azo Compounds; Brefeldin A | 2013 |
Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma.
Topics: Aged; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Choline; Cohort Studies; Humans; Liv | 2013 |
Vitamin B-6 restriction reduces the production of hydrogen sulfide and its biomarkers by the transsulfuration pathway in cultured human hepatoma cells.
Topics: Alanine; Biomarkers; Carcinoma, Hepatocellular; Cysteine; Hep G2 Cells; Homocysteine; Humans; Hydrog | 2014 |
Folate and vitamin B-6 status are not associated with homocysteine, oxidative stress and antioxidant capacities in patients with hepatocellular carcinoma.
Topics: Aged; Antioxidants; Carcinoma, Hepatocellular; Female; Folic Acid; Glutathione Peroxidase; Glutathio | 2016 |
Mangafodipir trisodium-enhanced MRI of hepatocellular carcinoma: correlation with histological characteristics.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cell Differentiation; Contrast Media; Edetic Acid; Female; H | 2008 |
Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.
Topics: Carcinoma, Hepatocellular; Cell Membrane; Delta-5 Fatty Acid Desaturase; Down-Regulation; Fatty Acid | 2013 |
Mn-DPDP-enhanced 24-h delayed-scan MRI of hepatocellular carcinoma is correlated with histology.
Topics: Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Humans; Liver; Liver Neoplasms; Magnetic Res | 2004 |
[Comparative study of four GRE sequences in MnDPDP-enhanced magnetic resonance imaging for primary hepatocellular carcinoma].
Topics: Adult; Aged; Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Female; Humans; Image Enhanceme | 2003 |
[STUDIES ON VITAMIN B6 METABOLISM OF CANCER CELLS AND TUMOR-BEARING RAT LIVER. I. ENZYME ACTIVITIES RELATED TO VITAMIN B6 METABOLISM].
Topics: Carcinoma, Hepatocellular; Flavin Mononucleotide; Liver; Liver Neoplasms; Metabolism; Neoplasms, Exp | 1964 |
[STUDIES ON VITAMIN B6 METABOLISM OF CANCER CELLS AND TUMOR-BEARING RAT LIVER. II. UPTAKE OF PYRIDOXINE DERIVATIVES BY TUMOR CELLS AND THE LIVER OF TUMOR-BEARING RATS].
Topics: Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Neoplasms; Neoplasms, Experimental; Permeability; | 1964 |
Mangafodipir prevents liver injury induced by acetaminophen in the mouse.
Topics: Acetaminophen; Animals; Antibodies, Monoclonal; Antioxidants; Carcinoma, Hepatocellular; Caspase 3; | 2003 |
Assessment of sequential enhancement patterns of focal nodular hyperplasia and hepatocellular carcinoma on mangafodipir trisodium enhanced MR imaging.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Female; Focal Nodular Hyperplas | 2004 |
MRI for detection of hepatocellular carcinoma: comparison of mangafodipir trisodium and gadopentetate dimeglumine contrast agents.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Contrast Media; Diagnosis, Differential; | 2004 |
Characterization of focal liver lesions: use of mangafodipir trisodium (MnDPDP)-enhanced MR images.
Topics: Adult; Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cholangiocarc | 2006 |
Differentiation of hepatomas from nonhepatomatous masses: use of MnDPDP-enhanced MR images.
Topics: Carcinoma, Hepatocellular; Contrast Media; Diagnosis, Differential; Edetic Acid; Hemangioma, Caverno | 1994 |
Experimental liver cancers: Mn-DPDP-enhanced rims in MR-microangiographic-histologic correlation study.
Topics: Angiography; Animals; Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Liver Neoplasms; Liver | 1993 |
Comparison of gadolinium chelates with manganese-DPDP for liver lesion detection and characterization: preliminary results.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Contrast Media; Cysts; Edetic Acid; Female; Gadolinium; Gado | 1996 |
Mangafodipir trisodium (MnDPDP)-enhanced magnetic resonance imaging of the liver and pancreas.
Topics: Adenocarcinoma; Adenoma, Islet Cell; Adipose Tissue; Adult; Aged; Aged, 80 and over; Blood-Brain Bar | 1998 |
Technical report: lymph node enhancement at MRI with MnDPDP in primary hepatic carcinoma.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Contrast Media; Edetic Acid; Humans; Liver Neoplasms; Lympha | 2001 |
Effects of diallyl disulfide and other donors of sulfane sulfur on the proliferation of human hepatoma cell line (HepG2).
Topics: Allyl Compounds; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Cystamine; Disulfi | 2001 |
Vitamin B6 concentrations in patients with chronic liver disease and hepatocellular carcinoma.
Topics: Adolescent; Adult; Aged; Carcinoma, Hepatocellular; Humans; Liver Diseases; Liver Neoplasms; Middle | 1986 |
The properties, developmental formation, and estrogen induction of ornithine aminotransferase in rat tissues.
Topics: Animals; Carcinoma, Hepatocellular; Castration; Enzyme Induction; Estradiol; Female; Fetus; Intestin | 1968 |
[New route of regulating folic acid metabolism in experimental chemotherapy of leukoses and malignant neoplasms].
Topics: Animals; Carcinoma, Hepatocellular; Cycloserine; Female; Folic Acid; Leukemia, Experimental; Liver; | 1971 |
Histidine decarboxylase in the transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis.
Topics: Ammonium Sulfate; Animals; Carboxy-Lyases; Carcinoid Tumor; Carcinoma, Ehrlich Tumor; Carcinoma, Hep | 1971 |
Fluorometric determination of pyridoxal phosphate in microgram samples of tissue.
Topics: Adrenal Glands; Animals; Carcinoid Tumor; Carcinoma, Hepatocellular; Cattle; Cyanides; Evaluation St | 1972 |
[Isoenzyme spectrum of serine transoxymethylase in the liver and in hepatomas].
Topics: Agar; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Electrophoresis; Gels; Glycine; Isoenzyme | 1973 |
Ornithine decarboxylase turnover slowed by alpha-hydrazino-ornithine.
Topics: Animals; Brain; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Cycloheximide; Dith | 1974 |