pyridoxal phosphate has been researched along with Autoimmune Diabetes in 7 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sera obtained from Japanese SPIDDM (n = 17) and AIDDM (n = 46) patients followed prospectively were analyzed by immunoprecipitation, ELISA, and Western blotting." | 1.32 | Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes. ( Kobayashi, T; Lernmark, A; Murase, T; Nakanishi, K; Okubo, M; Tanaka, S, 2003) |
| "GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease." | 1.31 | Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding. ( Falorni, A; Hammerle, LP; Hampe, CS; Lernmark, A; Robertson, J, 2001) |
| "Of 45 type 1 diabetes sera tested, 30 (67%) had an 80% or greater reduction of reactivity to GAD65(delta258-270) vs." | 1.31 | The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera. ( Mackay, IR; Myers, MA; Rowley, MJ; Tong, JC; Zimmet, PZ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rubí, B | 1 |
| Massé, PG | 1 |
| Boudreau, J | 1 |
| Tranchant, CC | 1 |
| Ouellette, R | 1 |
| Ericson, KL | 1 |
| Kobayashi, T | 1 |
| Tanaka, S | 1 |
| Okubo, M | 1 |
| Nakanishi, K | 1 |
| Murase, T | 1 |
| Lernmark, A | 2 |
| Sköldberg, F | 1 |
| Rorsman, F | 1 |
| Perheentupa, J | 1 |
| Landin-Olsson, M | 1 |
| Husebye, ES | 1 |
| Gustafsson, J | 1 |
| Kämpe, O | 1 |
| Myers, MA | 2 |
| Davies, JM | 1 |
| Tong, JC | 2 |
| Whisstock, J | 1 |
| Scealy, M | 1 |
| Mackay, IR | 2 |
| Rowley, MJ | 2 |
| Hampe, CS | 1 |
| Hammerle, LP | 1 |
| Falorni, A | 1 |
| Robertson, J | 1 |
| Zimmet, PZ | 1 |
7 other studies available for pyridoxal phosphate and Autoimmune Diabetes
| Article | Year |
|---|---|
Pyridoxal 5'-phosphate (PLP) deficiency might contribute to the onset of type I diabetes.
Topics: Autoimmunity; Diabetes Mellitus, Type 1; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; I | 2012 |
Type 1 diabetes impairs vitamin B(6) metabolism at an early stage of women's adulthood.
Topics: Adult; Age Factors; Alkaline Phosphatase; Biomarkers; Case-Control Studies; Chi-Square Distribution; | 2012 |
Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes.
Topics: Autoantibodies; Binding Sites; Diabetes Mellitus, Type 1; Enzyme-Linked Immunosorbent Assay; Epitope | 2003 |
Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease.
Topics: Addison Disease; Aromatic-L-Amino-Acid Decarboxylases; Autoantibodies; Carboxy-Lyases; Cross Reactio | 2004 |
Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigen-Antibody Reactions; Autoantigens; Binding Sites | 2000 |
Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Autoantibodies; Autoantigens; Binding Sites; | 2001 |
The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera.
Topics: Amino Acid Sequence; Amino Acid Substitution; B-Lymphocytes; Diabetes Mellitus, Type 1; Epitopes, B- | 2002 |