pyridoxal phosphate has been researched along with Aura in 62 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study testifies an assumption on epilepsy as an inborn error of pyridoxine metabolism and suggests non-invasive quantitative biomarkers for clarified evaluation of clinical status and monitoring an individual treatment by antiepileptic drugs." | 9.16 | Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment. ( Dolina, S; Malitsky, S; Margalit, D; Pressman, E; Rabinkov, A, 2012) |
| "To investigate the short-term efficacy and safety of high-dose pyridoxine and pyridoxal 5-phosphate (P5P) in the treatment of inherited glycosylphosphatidylinositol (GPI) deficiency-associated epilepsy." | 8.12 | Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study. ( Aledo-Serrano, A; Bayat, A; Boßelmann, C; de Sain-van der Velden, MGM; Gardella, E; Gil-Nagel, A; Korff, CM; Lund, AM; Møller, RS; Thomas, A; Weber, Y, 2022) |
| "Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters." | 7.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "α-Amino adipic semialdehyde (α-AASA) accumulates in body fluids from patients with pyridoxine-dependent epilepsy because of mutations in antiquitin (ALDH7A1) and serves as the biomarker for this condition." | 7.78 | Pyridoxine-dependent epilepsy with elevated urinary α-amino adipic semialdehyde in molybdenum cofactor deficiency. ( Al Shahwan, S; Bakkali, A; Nota, B; Salomons, GS; Struys, EA; Tabarki, B, 2012) |
| "Pyridoxine-dependent epilepsy (PDE) is a treatable inborn error of metabolism with autosomal recessive inheritance." | 7.77 | Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity? ( Fingerhut, M; Hartmann, H; Jakobs, C; Plecko, B, 2011) |
| "We report on seizures, paroxysmal events, and electroencephalogram (EEG) findings in four female infants with pyridoxine-dependent epilepsy (PDE) and in one female with pyridoxine phosphate oxidase deficiency (PNPO)." | 7.76 | Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. ( Baumgartner, M; Clayton, PT; Jakobs, C; Keller, E; Mills, PB; Schmitt, B; Wohlrab, G, 2010) |
| "Patients with pyridoxine dependent epilepsy (PDE) present with early-onset seizures resistant to common anticonvulsants." | 7.74 | Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene. ( Baumeister, F; Bosch, F; di Capua, M; Erwa, W; Freilinger, M; Hartmann, H; Hikel, C; Jakobs, C; Korenke, C; Luecke, T; Paschke, E; Paul, K; Plecko, B; Reutershahn, E; Stoeckler-Ipsiroglu, S; Struys, E, 2007) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 7.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| "Diagnosis of pyridoxine-dependent epilepsy is based on the clinical response to high-dosage application of pyridoxine." | 7.70 | Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy. ( Erwa, W; Jakobs, C; Paschke, E; Plecko, B; Stöckler-Ipsiroglu, S; Struys, EA, 2000) |
| "Pyridoxine-dependent epilepsy is a rare autosomal recessive disorder." | 7.69 | Glutamate in pyridoxine-dependent epilepsy: neurotoxic glutamate concentration in the cerebrospinal fluid and its normalization by pyridoxine. ( Baumeister, FA; Egger, J; Gsell, W; Shin, YS, 1994) |
| "Pyridoxal phosphate was extremely high in CSF and plasma." | 5.40 | Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures. ( Abeling, NGGM; Bosch, AM; Cobben, JM; de Roo, MGA; Duran, M; Koelman, JHTM; Majoie, CB; Poll-The, BT, 2014) |
| "The study testifies an assumption on epilepsy as an inborn error of pyridoxine metabolism and suggests non-invasive quantitative biomarkers for clarified evaluation of clinical status and monitoring an individual treatment by antiepileptic drugs." | 5.16 | Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment. ( Dolina, S; Malitsky, S; Margalit, D; Pressman, E; Rabinkov, A, 2012) |
| " Antiquitin deficiency is the most common form of pyridoxine-dependent epilepsy." | 5.05 | Inherited Disorders of Lysine Metabolism: A Review. ( Bouchereau, J; Schiff, M, 2020) |
| " Pyridoxine dependent epilepsy is a treatable condition with a potentially widening clinical spectrum, but with a prognosis dependent on early intervention." | 4.82 | Clinical aspects of the disorders of GABA metabolism in children. ( Gibson, KM; Pearl, PL, 2004) |
| "To investigate the short-term efficacy and safety of high-dose pyridoxine and pyridoxal 5-phosphate (P5P) in the treatment of inherited glycosylphosphatidylinositol (GPI) deficiency-associated epilepsy." | 4.12 | Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study. ( Aledo-Serrano, A; Bayat, A; Boßelmann, C; de Sain-van der Velden, MGM; Gardella, E; Gil-Nagel, A; Korff, CM; Lund, AM; Møller, RS; Thomas, A; Weber, Y, 2022) |
| "Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters." | 3.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in the cerebrospinal fluid (CSF) of children and to investigate the effect of age, sex, epilepsy, and anti-epileptic drug (AED) therapy on these vitamers." | 3.85 | Measurement of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children. ( Akiyama, M; Akiyama, T; Hamano, SI; Hanaoka, Y; Hayashi, Y; Imai, K; Kobayashi, K; Okanishi, T; Shibata, T; Toda, S; Yoshinaga, H, 2017) |
| " Thiosemicarbazide (TSC) and γ-glutamyl-hydrazone (PLPGH) inhibit the free PLP-dependent isoform (GAD65) activity after systemic administration, leading to epilepsy in mice and in young, but not in adult rats." | 3.81 | Epilepsy and hippocampal neurodegeneration induced by glutamate decarboxylase inhibitors in awake rats. ( Salazar, P; Tapia, R, 2015) |
| "To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations." | 3.80 | Pyridoxine responsiveness in novel mutations of the PNPO gene. ( Abela, L; Clayton, P; Connolly, M; Hasselmann, O; Hofer, D; Kanz, S; Maier, O; Mills, P; Paschke, E; Paul, K; Plecko, B; Schmiedel, G; Stockler, S; Struys, E; Wolf, N, 2014) |
| "α-Amino adipic semialdehyde (α-AASA) accumulates in body fluids from patients with pyridoxine-dependent epilepsy because of mutations in antiquitin (ALDH7A1) and serves as the biomarker for this condition." | 3.78 | Pyridoxine-dependent epilepsy with elevated urinary α-amino adipic semialdehyde in molybdenum cofactor deficiency. ( Al Shahwan, S; Bakkali, A; Nota, B; Salomons, GS; Struys, EA; Tabarki, B, 2012) |
| "Pyridoxine-dependent epilepsy (PDE) is a treatable inborn error of metabolism with autosomal recessive inheritance." | 3.77 | Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity? ( Fingerhut, M; Hartmann, H; Jakobs, C; Plecko, B, 2011) |
| "We report on seizures, paroxysmal events, and electroencephalogram (EEG) findings in four female infants with pyridoxine-dependent epilepsy (PDE) and in one female with pyridoxine phosphate oxidase deficiency (PNPO)." | 3.76 | Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. ( Baumgartner, M; Clayton, PT; Jakobs, C; Keller, E; Mills, PB; Schmitt, B; Wohlrab, G, 2010) |
| "Patients with pyridoxine dependent epilepsy (PDE) present with early-onset seizures resistant to common anticonvulsants." | 3.74 | Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene. ( Baumeister, F; Bosch, F; di Capua, M; Erwa, W; Freilinger, M; Hartmann, H; Hikel, C; Jakobs, C; Korenke, C; Luecke, T; Paschke, E; Paul, K; Plecko, B; Reutershahn, E; Stoeckler-Ipsiroglu, S; Struys, E, 2007) |
| "In the mouse, neurotransmitter metabolism can be regulated by modulation of the synthesis of pyridoxal 5'-phosphate and failure to maintain pyridoxal phosphate (PLP) levels results in epilepsy." | 3.73 | Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. ( Beesley, CE; Briddon, A; Champion, MP; Clayton, PT; Dalton, N; Heales, SJ; Hoffmann, GF; Mills, PB; Scambler, PJ; Scheimberg, I; Surtees, RA; Zschocke, J, 2005) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 3.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| "Elevated concentrations of pipecolic acid have been reported in plasma and CSF of patients with pyridoxine-dependent epilepsy, but its molecular background is unclear." | 3.73 | Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats. ( Hoeger, H; Jakobs, C; Leschnik, M; Muehl, A; Plecko, B; Stoeckler-Ipsiroglu, S; Stromberger, C; Struys, E, 2005) |
| "Diagnosis of pyridoxine-dependent epilepsy is based on the clinical response to high-dosage application of pyridoxine." | 3.70 | Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy. ( Erwa, W; Jakobs, C; Paschke, E; Plecko, B; Stöckler-Ipsiroglu, S; Struys, EA, 2000) |
| "Pyridoxine-dependent epilepsy is a rare autosomal recessive disorder." | 3.69 | Glutamate in pyridoxine-dependent epilepsy: neurotoxic glutamate concentration in the cerebrospinal fluid and its normalization by pyridoxine. ( Baumeister, FA; Egger, J; Gsell, W; Shin, YS, 1994) |
| "In spite of effective seizure control with PLP, approximately 56% of patients affected with PLP-dependent epilepsy suffer developmental delay/intellectual disability." | 2.72 | Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency. ( Abdelhakim, M; Adly, N; Alghamdi, M; Alghanem, B; Arold, ST; Bashiri, FA; Jamjoom, DZ; Sumaily, KM, 2021) |
| "Treatment with pyridoxine significantly improved the epileptic phenotype and extended lifespan in plpbp-/- animals." | 1.51 | PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights. ( Abdelrahim, RA; Al Futaisi, A; Al-Shekaili, HH; Al-Thihli, K; Arnold, GL; Ban, K; Begtrup, A; Boon, M; Bosma, M; Boycott, KM; Brimble, E; Bui, T; Cho, MT; Ciapaite, J; Demarest, S; Drögemöller, B; Dyment, DA; Ekker, M; Friedman, JM; Gerkes, EH; Haaxma, CA; Heiner-Fokkema, MR; Houten, SM; Ito, Y; Ivy, AS; Jans, J; Johnstone, DL; Kamsteeg, EJ; Kema, IP; Kernohan, KD; Koolen, DA; Kosuta, C; Koul, R; Lepage, N; Lines, MA; Majewski, J; McBride, S; Noble, S; Olson, H; Pena, IA; Ross, CJ; Roussel, Y; Sigurdardottir, LY; Tarailo-Graovac, M; van Faassen, M; van Karnebeek, CDM; van Roermund, CWT; Verhoeven-Duif, N; Violante, S; Wanders, RJA; Wasserman, WW; Wevers, RA; Wolf, NI, 2019) |
| "Pyridoxal phosphate was extremely high in CSF and plasma." | 1.40 | Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures. ( Abeling, NGGM; Bosch, AM; Cobben, JM; de Roo, MGA; Duran, M; Koelman, JHTM; Majoie, CB; Poll-The, BT, 2014) |
| "Vitamin B(6) dependent seizure disorders are an important and treatable cause of childhood epilepsy." | 1.39 | Measurement of plasma B6 vitamer profiles in children with inborn errors of vitamin B6 metabolism using an LC-MS/MS method. ( Clayton, PT; Footitt, EJ; Heales, SJ; Mills, K; Mills, PB; Neergheen, V; Oppenheim, M, 2013) |
| "Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism." | 1.34 | Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. ( Bagci, S; Bast, T; Baumgartner, MR; Clayton, PT; Franz, AR; Hoffmann, GF; Mills, PB; Schmitt, B; Steinmann, B; Strehl, H; Wagner, N; Windfuhr, M; Wolf, NI; Zschocke, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (20.97) | 18.7374 |
| 1990's | 3 (4.84) | 18.2507 |
| 2000's | 17 (27.42) | 29.6817 |
| 2010's | 22 (35.48) | 24.3611 |
| 2020's | 7 (11.29) | 2.80 |
| Authors | Studies |
|---|---|
| Barile, A | 1 |
| Mills, P | 2 |
| di Salvo, ML | 1 |
| Graziani, C | 1 |
| Bunik, V | 1 |
| Clayton, P | 2 |
| Contestabile, R | 1 |
| Tramonti, A | 1 |
| Bayat, A | 1 |
| Aledo-Serrano, A | 1 |
| Gil-Nagel, A | 1 |
| Korff, CM | 1 |
| Thomas, A | 1 |
| Boßelmann, C | 1 |
| Weber, Y | 1 |
| Gardella, E | 1 |
| Lund, AM | 1 |
| de Sain-van der Velden, MGM | 1 |
| Møller, RS | 1 |
| Plecko, B | 7 |
| Alghamdi, M | 1 |
| Bashiri, FA | 1 |
| Abdelhakim, M | 1 |
| Adly, N | 1 |
| Jamjoom, DZ | 1 |
| Sumaily, KM | 1 |
| Alghanem, B | 1 |
| Arold, ST | 1 |
| Akiyama, T | 2 |
| Hyodo, Y | 1 |
| Hasegawa, K | 1 |
| Oboshi, T | 1 |
| Imai, K | 2 |
| Ishihara, N | 1 |
| Dowa, Y | 1 |
| Koike, T | 1 |
| Yamamoto, T | 1 |
| Shibasaki, J | 1 |
| Shimbo, H | 1 |
| Fukuyama, T | 1 |
| Takano, K | 1 |
| Shiraku, H | 1 |
| Takeshita, S | 1 |
| Okanishi, T | 2 |
| Baba, S | 1 |
| Kubota, M | 1 |
| Hamano, SI | 2 |
| Kobayashi, K | 2 |
| Bouchereau, J | 1 |
| Schiff, M | 2 |
| Klotz, KA | 1 |
| Lemke, JR | 1 |
| Korinthenberg, R | 1 |
| Jacobs, J | 1 |
| Wilson, MP | 2 |
| Footitt, EJ | 5 |
| Papandreou, A | 1 |
| Uudelepp, ML | 1 |
| Pressler, R | 1 |
| Stevenson, DC | 1 |
| Gabriel, C | 1 |
| McSweeney, M | 1 |
| Baggot, M | 1 |
| Burke, D | 1 |
| Stödberg, T | 2 |
| Riney, K | 2 |
| Heales, SJR | 1 |
| Mills, KA | 2 |
| Gissen, P | 2 |
| Clayton, PT | 9 |
| Mills, PB | 8 |
| Tremiño, L | 1 |
| Forcada-Nadal, A | 1 |
| Contreras, A | 1 |
| Rubio, V | 1 |
| Guerriero, RM | 1 |
| Patel, AA | 1 |
| Walsh, B | 1 |
| Baumer, FM | 1 |
| Shah, AS | 1 |
| Peters, JM | 1 |
| Rodan, LH | 1 |
| Agrawal, PB | 1 |
| Pearl, PL | 3 |
| Takeoka, M | 1 |
| Johnstone, DL | 1 |
| Al-Shekaili, HH | 1 |
| Tarailo-Graovac, M | 1 |
| Wolf, NI | 3 |
| Ivy, AS | 1 |
| Demarest, S | 1 |
| Roussel, Y | 1 |
| Ciapaite, J | 1 |
| van Roermund, CWT | 1 |
| Kernohan, KD | 1 |
| Kosuta, C | 1 |
| Ban, K | 1 |
| Ito, Y | 1 |
| McBride, S | 1 |
| Al-Thihli, K | 1 |
| Abdelrahim, RA | 1 |
| Koul, R | 1 |
| Al Futaisi, A | 1 |
| Haaxma, CA | 1 |
| Olson, H | 1 |
| Sigurdardottir, LY | 1 |
| Arnold, GL | 1 |
| Gerkes, EH | 1 |
| Boon, M | 1 |
| Heiner-Fokkema, MR | 1 |
| Noble, S | 1 |
| Bosma, M | 1 |
| Jans, J | 1 |
| Koolen, DA | 1 |
| Kamsteeg, EJ | 1 |
| Drögemöller, B | 1 |
| Ross, CJ | 1 |
| Majewski, J | 1 |
| Cho, MT | 1 |
| Begtrup, A | 1 |
| Wasserman, WW | 1 |
| Bui, T | 1 |
| Brimble, E | 1 |
| Violante, S | 1 |
| Houten, SM | 1 |
| Wevers, RA | 1 |
| van Faassen, M | 1 |
| Kema, IP | 1 |
| Lepage, N | 1 |
| Lines, MA | 1 |
| Dyment, DA | 1 |
| Wanders, RJA | 1 |
| Verhoeven-Duif, N | 1 |
| Ekker, M | 1 |
| Boycott, KM | 1 |
| Friedman, JM | 1 |
| Pena, IA | 2 |
| van Karnebeek, CDM | 1 |
| de Roo, MGA | 1 |
| Abeling, NGGM | 1 |
| Majoie, CB | 1 |
| Bosch, AM | 1 |
| Koelman, JHTM | 1 |
| Cobben, JM | 1 |
| Duran, M | 1 |
| Poll-The, BT | 1 |
| Camuzeaux, SS | 1 |
| Fisher, L | 1 |
| Das, KB | 1 |
| Varadkar, SM | 1 |
| Zuberi, S | 1 |
| McWilliam, R | 1 |
| Baumgartner, MR | 2 |
| Maier, O | 2 |
| Calvert, S | 1 |
| Livingston, JH | 1 |
| Bala, P | 1 |
| Morel, CF | 1 |
| Feillet, F | 1 |
| Raimondi, F | 1 |
| Del Giudice, E | 1 |
| Chong, WK | 1 |
| Pitt, M | 1 |
| Paul, K | 2 |
| Paschke, E | 3 |
| Hasselmann, O | 1 |
| Schmiedel, G | 1 |
| Kanz, S | 1 |
| Connolly, M | 1 |
| Wolf, N | 2 |
| Struys, E | 3 |
| Stockler, S | 1 |
| Abela, L | 1 |
| Hofer, D | 1 |
| Dietmann, A | 1 |
| Wallner, B | 1 |
| König, R | 1 |
| Friedrich, K | 1 |
| Pfausler, B | 1 |
| Deisenhammer, F | 1 |
| Griesmacher, A | 1 |
| Seger, C | 1 |
| Matuja, W | 1 |
| JilekAall, L | 1 |
| Winkler, AS | 1 |
| Schmutzhard, E | 1 |
| Salazar, P | 1 |
| Tapia, R | 1 |
| Marques, LA | 1 |
| Laranjeira, ÂB | 1 |
| Yunes, JA | 1 |
| Eberlin, MN | 1 |
| MacKenzie, A | 1 |
| Arruda, P | 1 |
| Akiyama, M | 1 |
| Hayashi, Y | 1 |
| Shibata, T | 1 |
| Hanaoka, Y | 1 |
| Toda, S | 1 |
| Yoshinaga, H | 1 |
| Mohamed-Ahmed, AH | 1 |
| Albuera, M | 1 |
| Chen, T | 1 |
| Tuleu, C | 1 |
| Cortès-Saladelafont, E | 1 |
| Molero-Luis, M | 1 |
| Artuch, R | 2 |
| García-Cazorla, À | 1 |
| Gospe, SM | 1 |
| Schmitt, B | 2 |
| Baumgartner, M | 1 |
| Jakobs, C | 6 |
| Keller, E | 1 |
| Wohlrab, G | 1 |
| Veerapandiyan, A | 1 |
| Winchester, SA | 1 |
| Gallentine, WB | 1 |
| Smith, EC | 1 |
| Kansagra, S | 1 |
| Hyland, K | 1 |
| Mikati, MA | 1 |
| Heales, SJ | 3 |
| Allen, GF | 1 |
| Oppenheim, M | 2 |
| Hartmann, H | 2 |
| Fingerhut, M | 1 |
| Dill, P | 1 |
| Schneider, J | 1 |
| Weber, P | 1 |
| Trachsel, D | 1 |
| Tekin, M | 1 |
| Thöny, B | 1 |
| Blau, N | 1 |
| Mills, K | 1 |
| Neergheen, V | 1 |
| Dolina, S | 1 |
| Margalit, D | 1 |
| Malitsky, S | 1 |
| Pressman, E | 1 |
| Rabinkov, A | 1 |
| Struys, EA | 2 |
| Nota, B | 1 |
| Bakkali, A | 1 |
| Al Shahwan, S | 1 |
| Salomons, GS | 1 |
| Tabarki, B | 1 |
| Wang, H | 1 |
| Kuo, M | 1 |
| Gibson, KM | 1 |
| Tutor-Crespo, MJ | 2 |
| Hermida, J | 2 |
| Tutor, JC | 2 |
| Surtees, RA | 1 |
| Champion, MP | 1 |
| Beesley, CE | 1 |
| Dalton, N | 1 |
| Scambler, PJ | 1 |
| Briddon, A | 1 |
| Scheimberg, I | 1 |
| Hoffmann, GF | 3 |
| Zschocke, J | 4 |
| Wang, HS | 1 |
| Kuo, MF | 1 |
| Chou, ML | 1 |
| Hung, PC | 1 |
| Lin, KL | 1 |
| Hsieh, MY | 1 |
| Chang, MY | 1 |
| Hoeger, H | 1 |
| Stromberger, C | 1 |
| Leschnik, M | 1 |
| Muehl, A | 1 |
| Stoeckler-Ipsiroglu, S | 2 |
| Sener, U | 1 |
| Zorlu, Y | 1 |
| Karaguzel, O | 1 |
| Ozdamar, O | 1 |
| Coker, I | 1 |
| Topbas, M | 1 |
| Attilakos, A | 1 |
| Papakonstantinou, E | 1 |
| Schulpis, K | 1 |
| Voudris, K | 1 |
| Katsarou, E | 1 |
| Mastroyianni, S | 1 |
| Garoufi, A | 1 |
| Luecke, T | 1 |
| di Capua, M | 1 |
| Korenke, C | 1 |
| Hikel, C | 1 |
| Reutershahn, E | 1 |
| Freilinger, M | 1 |
| Baumeister, F | 1 |
| Bosch, F | 1 |
| Erwa, W | 2 |
| Windfuhr, M | 1 |
| Wagner, N | 1 |
| Strehl, H | 1 |
| Bagci, S | 2 |
| Franz, AR | 2 |
| Steinmann, B | 1 |
| Bast, T | 2 |
| Surtees, R | 1 |
| Ruiz, A | 1 |
| García-Villoria, J | 1 |
| Ormazabal, A | 1 |
| Fiol, M | 1 |
| Navarro-Sastre, A | 1 |
| Vilaseca, MA | 1 |
| Ribes, A | 1 |
| Klepper, J | 1 |
| Müller, A | 1 |
| Heep, A | 1 |
| Bartmann, P | 1 |
| Kang, TC | 1 |
| Kang, JH | 1 |
| Kim, HT | 1 |
| Lee, SJ | 1 |
| Choi, UK | 1 |
| Kim, JE | 1 |
| Kwak, SE | 1 |
| Kim, DW | 1 |
| Choi, SY | 1 |
| Kwon, OS | 1 |
| Chung, SH | 2 |
| Johnson, MS | 1 |
| Shandra, AA | 2 |
| Kryzhanovskiĭ, GN | 2 |
| Godlevskiĭ, LS | 1 |
| Hammad, HM | 1 |
| Al-Sayegh, A | 1 |
| Swanson, S | 1 |
| Ebadi, M | 2 |
| Kouyoumdjian, JC | 1 |
| Waymire, KG | 1 |
| Mahuren, JD | 1 |
| Jaje, JM | 1 |
| Guilarte, TR | 1 |
| Coburn, SP | 1 |
| MacGregor, GR | 1 |
| Baumeister, FA | 1 |
| Gsell, W | 1 |
| Shin, YS | 1 |
| Egger, J | 1 |
| Ross, FM | 1 |
| Brodie, MJ | 1 |
| Stone, TW | 1 |
| Stöckler-Ipsiroglu, S | 1 |
| Lott, IT | 1 |
| Coulombe, T | 1 |
| Di Paolo, RV | 1 |
| Richardson, EP | 1 |
| Levy, HL | 1 |
| Reinken, L | 1 |
| Gabrielsson, B | 1 |
| Norris, DK | 1 |
| Krause, KH | 1 |
| Bonjour, JP | 1 |
| Berlit, P | 1 |
| Kynast, G | 1 |
| Schmidt-Gayk, H | 1 |
| Arab, L | 1 |
| Papeschi, R | 1 |
| Molina-Negro, P | 1 |
| Sourkes, TL | 1 |
| Erba, G | 1 |
| Antón-Tay, F | 1 |
| Hagberg, B | 2 |
| Hamfelt, A | 1 |
| Hansson, O | 2 |
8 reviews available for pyridoxal phosphate and Aura
| Article | Year |
|---|---|
On pathways and blind alleys-The importance of biomarkers in vitamin B
Topics: Biomarkers; Epilepsy; Humans; Infant, Newborn; Pyridoxal Phosphate; Pyridoxine; Vitamin B 6; Vitamin | 2023 |
Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency.
Topics: Brain Diseases, Metabolic; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Mutation; | 2021 |
Inherited Disorders of Lysine Metabolism: A Review.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Arginine; Brain; B | 2020 |
Electroencephalographic and seizure manifestations of pyridoxal 5'-phosphate-dependent epilepsy.
Topics: Child, Preschool; Electroencephalography; Epilepsy; Humans; Infant; Male; Mutation; Pyridoxal Phosph | 2011 |
Clinical aspects of the disorders of GABA metabolism in children.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Amino Acid Metabolism, Inborn Errors; Brain; | 2004 |
Studies on sound-induced epilepsy in mice.
Topics: Acoustic Stimulation; Amino Acids; Animals; Brain; Copper; Epilepsy; Female; Male; Mice; Mice, Inbre | 1984 |
Transition metal ions in epilepsy: an overview.
Topics: Amino Acids; Animals; Biological Transport; Cations, Divalent; Enzymes; Epilepsy; Extracellular Spac | 1986 |
Melatonin: effects on brain function.
Topics: Adenylyl Cyclases; Aminobutyrates; Animals; Behavior; Brain; Cerebral Cortex; Cyclic AMP; Electric S | 1974 |
1 trial available for pyridoxal phosphate and Aura
| Article | Year |
|---|---|
Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment.
Topics: Adolescent; Anticonvulsants; Biomarkers; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Py | 2012 |
53 other studies available for pyridoxal phosphate and Aura
| Article | Year |
|---|---|
Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5'-Phosphate Oxidase-Dependent Epilepsy.
Topics: Brain Diseases, Metabolic; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Metabolic Dis | 2021 |
Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study.
Topics: Cohort Studies; Drug Resistant Epilepsy; Epilepsy; Female; Glycosylphosphatidylinositols; Humans; In | 2022 |
Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate.
Topics: 5-Hydroxytryptophan; Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, | 2020 |
Vitamin B6-Responsive Epilepsy due to a Novel KCNQ2 Mutation.
Topics: Anticonvulsants; Brain; Epilepsy; Female; Humans; Infant; KCNQ2 Potassium Channel; Mutation; Pyridox | 2017 |
An LC-MS/MS-Based Method for the Quantification of Pyridox(am)ine 5'-Phosphate Oxidase Activity in Dried Blood Spots from Patients with Epilepsy.
Topics: Adolescent; Adult; Area Under Curve; Case-Control Studies; Child; Child, Preschool; Chromatography, | 2017 |
Studies on cyanobacterial protein PipY shed light on structure, potential functions, and vitamin B
Topics: Amino Acid Motifs; Bacterial Proteins; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Cy | 2017 |
Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency.
Topics: Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Female; Humans; Hypoxia-Ischemia, Brain | 2017 |
PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; HEK293 Cells; Humans; Male; Phenotype; Proteins; | 2019 |
The effectiveness of correcting abnormal metabolic profiles.
Topics: 3-Hydroxysteroid Dehydrogenases; Administration, Oral; Bile Acids and Salts; Epilepsy; Humans; Metab | 2020 |
Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures.
Topics: Alkaline Phosphatase; Drug Resistance; Epilepsy; Humans; Hypophosphatasia; Infant; Male; Pyridoxal P | 2014 |
Epilepsy due to PNPO mutations: genotype, environment and treatment affect presentation and outcome.
Topics: Anticonvulsants; Child; Child, Preschool; Electroencephalography; Environment; Epilepsy; Female; HeL | 2014 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Aldehyde Dehydrogenase; Alleles; Animals; Brain Diseases, Metabolic; CHO Cells; Chromosome Deletion; | 2014 |
Nodding syndrome in Tanzania may not be associated with circulating anti-NMDA-and anti-VGKC receptor antibodies or decreased pyridoxal phosphate serum levels-a pilot study.
Topics: Adolescent; Adult; Aged; Autoantibodies; Case-Control Studies; Epilepsy; Female; Humans; Male; Middl | 2014 |
Epilepsy and hippocampal neurodegeneration induced by glutamate decarboxylase inhibitors in awake rats.
Topics: Amino Acids; Animals; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2015 |
Mouse lysine catabolism to aminoadipate occurs primarily through the saccharopine pathway; implications for pyridoxine dependent epilepsy (PDE).
Topics: 2-Aminoadipic Acid; Animals; Epilepsy; Female; Lysine; Metabolic Networks and Pathways; Mice; Mice, | 2017 |
Measurement of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children.
Topics: Age Factors; Child; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Linear Models; M | 2017 |
Quality and stability of extemporaneous pyridoxal phosphate preparations used in the treatment of paediatric epilepsy.
Topics: Dietary Supplements; Dosage Forms; Drug Stability; Drug Storage; Epilepsy; Pharmaceutical Solutions; | 2017 |
Pyridoxal Phosphate Supplementation in Neuropediatric Disorders.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Pyridoxal Phosphate; Treatment Outcom | 2016 |
Pyridoxal phosphate dependency, a newly recognized treatable catastrophic epileptic encephalopathy.
Topics: Aldehyde Dehydrogenase; Epilepsy; Humans; Infant, Newborn; Metabolism, Inborn Errors; Pyridoxal Phos | 2007 |
Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency.
Topics: Aldehyde Dehydrogenase; Anticonvulsants; Brain; Brain Diseases, Metabolic; Diagnosis, Differential; | 2010 |
Pyridoxal 5'-phosphate in cerebrospinal fluid; factors affecting concentration.
Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Cysteine; Epilepsy; False Positive Reactions | 2011 |
Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity?
Topics: Adult; Aldehyde Dehydrogenase; Epilepsy; Female; Humans; Infant; Infant, Newborn; Infusions, Parente | 2011 |
Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
Topics: Base Sequence; Child; Codon, Nonsense; Congenital Abnormalities; Congenital Microtia; Dihydroxypheny | 2011 |
Measurement of plasma B6 vitamer profiles in children with inborn errors of vitamin B6 metabolism using an LC-MS/MS method.
Topics: Adolescent; Child; Child, Preschool; Chromatography, Liquid; Epilepsy; Humans; Metabolism, Inborn Er | 2013 |
Pyridoxine-dependent epilepsy with elevated urinary α-amino adipic semialdehyde in molybdenum cofactor deficiency.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Brain; Child, Preschool; Consanguinity; Developmental Di | 2012 |
Pyridoxine sometimes fails to be activated to pyridoxal phosphate.
Topics: Epilepsy; Humans; Pyridoxal Phosphate; Pyridoxine | 2002 |
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination; | 2004 |
Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase.
Topics: Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cricetinae; Cricetulus; DNA Mutational Analy | 2005 |
Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Sche | 2005 |
Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Brain; Disease Models, Animal; Epilepsy; Female | 2005 |
Effect of antiepileptic drugs on the urinary excretion of porphyrins in non-porphyric subjects.
Topics: Adult; Anticonvulsants; Cholestasis; Enzyme Induction; Enzymes; Epilepsy; Female; Glucaric Acid; Hum | 2005 |
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Aci | 2006 |
Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; H | 2006 |
Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene.
Topics: Aldehyde Dehydrogenase; Amino Acid Sequence; DNA Mutational Analysis; Epilepsy; Female; Humans; Infa | 2007 |
Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy.
Topics: Age of Onset; Brain Diseases; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; M | 2007 |
Treatable neonatal epilepsy.
Topics: Biomarkers; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Leucovorin; Metabolic Dise | 2007 |
A new fatal case of pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency.
Topics: Brain Diseases, Metabolic, Inborn; Codon, Nonsense; Epilepsy; Fatal Outcome; Genes, Recessive; Homov | 2008 |
Pyridoxal phosphate-dependent neonatal epileptic encephalopathy.
Topics: Brain Diseases; Child, Preschool; Consanguinity; DNA Mutational Analysis; Electroencephalography; Ep | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; | 2008 |
[Antiepileptic effects of synthetic pharmacologic agents and vitamin preparations used in combination].
Topics: Animals; Anticonvulsants; Crosses, Genetic; Diazepam; Drug Therapy, Combination; Epilepsy; Mice; Mic | 1984 |
[Effect of vitamin preparations on epileptic activity].
Topics: Animals; Drug Evaluation, Preclinical; Drug Therapy, Combination; Epilepsy; Kindling, Neurologic; Mi | 1984 |
Dissociation between epileptic seizures induced by convulsant drugs and alteration in the concentrations of pyridoxal phosphate in rat brain regions.
Topics: 3-Mercaptopropionic Acid; Allylglycine; Animals; Bicuculline; Brain; Convulsants; Epilepsy; Male; Pi | 1983 |
Anticonvulsant activity of muscimol and gamma-aminobutyric acid against pyridoxal phosphate-induced epileptic seizures.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decar | 1981 |
Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.
Topics: Alkaline Phosphatase; Animals; Brain Chemistry; Calcification, Physiologic; Disease Models, Animal; | 1995 |
Glutamate in pyridoxine-dependent epilepsy: neurotoxic glutamate concentration in the cerebrospinal fluid and its normalization by pyridoxine.
Topics: Adrenocorticotropic Hormone; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Genes, Reces | 1994 |
Modulation by adenine nucleotides of epileptiform activity in the CA3 region of rat hippocampal slices.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Electric Stimu | 1998 |
Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy.
Topics: 2-Aminoadipic Acid; Child; Epilepsy; Humans; Infant, Newborn; Male; Picolinic Acids; Pipecolic Acids | 2000 |
Vitamin B6-dependent seizures: pathology and chemical findings in brain.
Topics: Adolescent; Adult; Amino Acids; Brain; Cerebellar Cortex; Cerebral Cortex; Child; Child, Preschool; | 1978 |
The influence of antiepileptic drugs on vitamin B6 metabolism.
Topics: Anticonvulsants; Aspartate Aminotransferases; Child; Child, Preschool; Epilepsy; Erythrocytes; Human | 1975 |
B vitamins in epileptics.
Topics: Adult; Anticonvulsants; Biotin; Epilepsy; Erythrocytes; Female; Humans; Male; Pyridoxal Phosphate; P | 1986 |
The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Studies in patients with extrapyramidal disorders, epilepsy, and other diseases.
Topics: Adolescent; Adult; Basal Ganglia Diseases; Cerebral Palsy; Cerebral Ventricles; Diazepam; Dihydroxyp | 1972 |
Tryptophan load tests and pyridoxal-5-phosphate levels in epileptic children. I. Non-progressive brain damage and degenerative brain disorders.
Topics: Adolescent; Brain Diseases; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Pyridox | 1966 |
Tryptophan load tests and pyridoxal-5-phosphate levels in epileptic children. II. Cryptogenic epilepsy.
Topics: Child; Child, Preschool; Epilepsy; Humans; Infant; Pyridoxal Phosphate; Pyridoxine; Tryptophan | 1966 |