pyridoxal phosphate has been researched along with Alzheimer Disease in 2 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cu(II) complexes of Alzheimer's disease-related β-amyloid (Aβ) peptides exhibit metal-centered oxidation chemistry." | 1.37 | Vitamin B6s inhibit oxidative stress caused by Alzheimer's disease-related Cu(II)-β-amyloid complexes-cooperative action of phospho-moiety. ( Hashim, A; Juneja, K; Ming, LJ; Wang, L; Ye, Y; Zhao, Y, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashim, A | 1 |
| Wang, L | 1 |
| Juneja, K | 1 |
| Ye, Y | 1 |
| Zhao, Y | 1 |
| Ming, LJ | 1 |
| Miller, JW | 1 |
| Green, R | 1 |
| Mungas, DM | 1 |
| Reed, BR | 1 |
| Jagust, WJ | 1 |
2 other studies available for pyridoxal phosphate and Alzheimer Disease
| Article | Year |
|---|---|
Vitamin B6s inhibit oxidative stress caused by Alzheimer's disease-related Cu(II)-β-amyloid complexes-cooperative action of phospho-moiety.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Copper; Humans; Oxidative Stress; Reactive Oxygen Species; | 2011 |
Homocysteine, vitamin B6, and vascular disease in AD patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Angina Pectoris; Brain Infarction; Coronary Disease; Fem | 2002 |