pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid has been researched along with Disease Models, Animal in 32 studies
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid: a novel antagonist that selectively blocks P2 purinoceptor receptors; a useful tool to study co-transmission in tissues when ATP and coexisting neurotransmitters act in concert
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid : An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To clarify the basic mechanism involved in the pathophysiology of cystitis by characterizing the urodynamic parameters, pharmacologically relevant (muscarinic and purinergic) receptors, and the in vivo release of adenosine triphosphate (ATP) in the bladder of hydrochloric acid (HCl)-treated rats." | 7.76 | Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. ( Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A, 2010) |
| " In this study, we investigated the effect of the recently developed P2X3 and P2X2/3 receptor antagonist A-317491 on cyclophosphamide (CYP)-induced cystitis to determine whether a P2X receptor antagonist could be beneficial for the treatment of bladder overactivity induced by CYP." | 7.74 | Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats. ( Ikeda, M; Ito, K; Iwami, A; Katsura, H, 2008) |
| "To clarify the basic mechanism involved in the pathophysiology of cystitis by characterizing the urodynamic parameters, pharmacologically relevant (muscarinic and purinergic) receptors, and the in vivo release of adenosine triphosphate (ATP) in the bladder of hydrochloric acid (HCl)-treated rats." | 3.76 | Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. ( Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A, 2010) |
| " In this study, we investigated the effect of the recently developed P2X3 and P2X2/3 receptor antagonist A-317491 on cyclophosphamide (CYP)-induced cystitis to determine whether a P2X receptor antagonist could be beneficial for the treatment of bladder overactivity induced by CYP." | 3.74 | Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats. ( Ikeda, M; Ito, K; Iwami, A; Katsura, H, 2008) |
| " The effect of the P2 antagonists, suramin and PPADS, on the extent of oxygen-induced retinal neovascularization was analyzed." | 3.74 | Involvement of purinergic P2 receptors in experimental retinal neovascularization. ( Croxatto, JO; Gallo, JE; Kvanta, A; Mancini, J; Sarman, S; van der Ploeg, I, 2008) |
| " Therefore, the present study aimed to trial a modified injection regime using more frequent dosing of BBG to improve outcomes in this model of GVHD." | 1.62 | P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model. ( Adhikary, SR; Casolin, S; Cuthbertson, P; Geraghty, NJ; Sluyter, R; Watson, D, 2021) |
| "Mechanical allodynia was reversed on day 7 in the groups treated with BBG and PPADS." | 1.46 | Blockade of ATP P2X7 receptor enhances ischiatic nerve regeneration in mice following a crush injury. ( Almeida, FM; de Andrade, GM; Marques, SA; Martinez, AMB; Melo, PA; Oliveira, JT; Ribeiro, T; Tomaz, MA, 2017) |
| "Painful diabetic neuropathy causes hyperalgesia and does not respond to commonly used analgesics such as non-steroidal anti-inflammatory drugs or opioids at doses below those producing disruptive side effects." | 1.35 | Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy. ( Honda, K; Katsuragi, T; Koguchi, M; Migita, K; Moriyama, T; Takano, Y; Ueno, S, 2009) |
| "The PPADS administration decreased both tactile allodynia and thermal hyperalgesia in a time and dose dependent manner." | 1.35 | PPADS, a purinergic antagonist reduces Fos expression at spinal cord level in a mouse model of mononeuropathy. ( Albertini, R; Borsani, E; Colleoni, M; Labanca, M; Lonati, C; Panerai, AE; Rezzani, R; Rodella, LF; Sacerdote, P; Trovato, AE, 2008) |
| " Chronic administration of a nucleotidase-resistant agonist confers a beneficial effect in the CSQ model of heart failure, apparently via an activation of the cardiac P2X receptor." | 1.34 | P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure. ( Cronin, C; Gongora Nieto, M; Harrison, D; Jacobson, KA; Joshi, BV; Liang, BT; Shen, JB; Sonin, D, 2007) |
| "Both heat and mechanical hyperalgesia were observed at the VP ipsilateral to the IoN ligation." | 1.34 | P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain. ( Asai, H; Kawashima, K; Nagamine, K; Ozaki, N; Shinoda, M; Sugiura, Y, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 18 (56.25) | 29.6817 |
| 2010's | 12 (37.50) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Cuthbertson, P | 1 |
| Geraghty, NJ | 1 |
| Adhikary, SR | 1 |
| Casolin, S | 1 |
| Watson, D | 1 |
| Sluyter, R | 1 |
| Ribeiro, T | 1 |
| Oliveira, JT | 1 |
| Almeida, FM | 1 |
| Tomaz, MA | 1 |
| Melo, PA | 1 |
| Marques, SA | 1 |
| de Andrade, GM | 1 |
| Martinez, AMB | 1 |
| Pereira, VS | 1 |
| Casarotto, PC | 1 |
| Hiroaki-Sato, VA | 1 |
| Sartim, AG | 1 |
| Guimarães, FS | 1 |
| Joca, SR | 1 |
| Hill, CB | 1 |
| Grandgeorge, SH | 1 |
| Bavis, RW | 1 |
| Xiao, J | 1 |
| Huang, Y | 1 |
| Li, X | 1 |
| Li, L | 1 |
| Yang, T | 1 |
| Huang, L | 1 |
| Yang, L | 1 |
| Jiang, H | 1 |
| Li, H | 1 |
| Li, F | 1 |
| Leng, Y | 1 |
| Yamamoto, T | 1 |
| Kadowaki, M | 1 |
| Franke, H | 1 |
| Sauer, C | 1 |
| Rudolph, C | 1 |
| Krügel, U | 1 |
| Hengstler, JG | 1 |
| Illes, P | 1 |
| Puthussery, T | 1 |
| Fletcher, E | 1 |
| Migita, K | 1 |
| Moriyama, T | 1 |
| Koguchi, M | 1 |
| Honda, K | 1 |
| Katsuragi, T | 1 |
| Takano, Y | 1 |
| Ueno, S | 1 |
| Dergacheva, O | 1 |
| Kamendi, H | 1 |
| Wang, X | 2 |
| Pinol, RA | 1 |
| Frank, J | 1 |
| Gorini, C | 1 |
| Jameson, H | 1 |
| Lovett-Barr, MR | 1 |
| Mendelowitz, D | 1 |
| Kukulski, F | 1 |
| Ben Yebdri, F | 1 |
| Bahrami, F | 1 |
| Lévesque, SA | 1 |
| Martín-Satué, M | 1 |
| Sévigny, J | 1 |
| Chen, X | 1 |
| Gebhart, GF | 1 |
| Liu, YP | 1 |
| Yang, CS | 1 |
| Chen, MC | 1 |
| Sun, SH | 1 |
| Tzeng, SF | 1 |
| Yoshida, A | 1 |
| Kageyama, A | 1 |
| Fujino, T | 1 |
| Nozawa, Y | 1 |
| Yamada, S | 1 |
| Fu, LW | 1 |
| Longhurst, JC | 1 |
| Marcillo, A | 1 |
| Frydel, B | 1 |
| Bramlett, HM | 1 |
| Dietrich, WD | 1 |
| Mezzaroma, E | 1 |
| Toldo, S | 1 |
| Farkas, D | 1 |
| Seropian, IM | 1 |
| Van Tassell, BW | 1 |
| Salloum, FN | 1 |
| Kannan, HR | 1 |
| Menna, AC | 1 |
| Voelkel, NF | 1 |
| Abbate, A | 1 |
| Wenker, IC | 1 |
| Sobrinho, CR | 1 |
| Takakura, AC | 1 |
| Moreira, TS | 1 |
| Mulkey, DK | 1 |
| Tsuda, M | 1 |
| Shigemoto-Mogami, Y | 1 |
| Koizumi, S | 1 |
| Mizokoshi, A | 1 |
| Kohsaka, S | 1 |
| Salter, MW | 1 |
| Inoue, K | 1 |
| Dai, Y | 1 |
| Fukuoka, T | 1 |
| Wang, H | 1 |
| Yamanaka, H | 1 |
| Obata, K | 1 |
| Tokunaga, A | 1 |
| Noguchi, K | 1 |
| Arcuino, G | 1 |
| Takano, T | 1 |
| Lin, J | 1 |
| Peng, WG | 1 |
| Wan, P | 1 |
| Li, P | 1 |
| Xu, Q | 1 |
| Liu, QS | 1 |
| Goldman, SA | 1 |
| Nedergaard, M | 1 |
| Oliveira, MC | 1 |
| Parada, CA | 1 |
| Veiga, MC | 1 |
| Rodrigues, LR | 1 |
| Barros, SP | 1 |
| Tambeli, CH | 1 |
| Pérez-Rivera, AA | 1 |
| Fink, GD | 1 |
| Galligan, JJ | 1 |
| Kim, DS | 1 |
| Kwak, SE | 1 |
| Kim, JE | 1 |
| Won, MH | 1 |
| Kang, TC | 1 |
| Shen, JB | 1 |
| Cronin, C | 1 |
| Sonin, D | 1 |
| Joshi, BV | 1 |
| Gongora Nieto, M | 1 |
| Harrison, D | 1 |
| Jacobson, KA | 1 |
| Liang, BT | 1 |
| Shinoda, M | 1 |
| Kawashima, K | 1 |
| Ozaki, N | 1 |
| Asai, H | 1 |
| Nagamine, K | 1 |
| Sugiura, Y | 1 |
| Ito, K | 1 |
| Iwami, A | 1 |
| Katsura, H | 1 |
| Ikeda, M | 1 |
| Graciano, ML | 1 |
| Nishiyama, A | 1 |
| Jackson, K | 1 |
| Seth, DM | 1 |
| Ortiz, RM | 1 |
| Prieto-Carrasquero, MC | 1 |
| Kobori, H | 1 |
| Navar, LG | 1 |
| Borsani, E | 1 |
| Albertini, R | 1 |
| Colleoni, M | 1 |
| Sacerdote, P | 1 |
| Trovato, AE | 1 |
| Lonati, C | 1 |
| Labanca, M | 1 |
| Panerai, AE | 1 |
| Rezzani, R | 1 |
| Rodella, LF | 1 |
| Sarman, S | 1 |
| Mancini, J | 1 |
| van der Ploeg, I | 1 |
| Croxatto, JO | 1 |
| Kvanta, A | 1 |
| Gallo, JE | 1 |
| Zheng, JH | 1 |
| Chen, J | 1 |
32 other studies available for pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model.
Topics: Adult; Animals; B-Lymphocytes; Disease Models, Animal; Female; Graft vs Host Disease; Hematopoietic | 2021 |
Blockade of ATP P2X7 receptor enhances ischiatic nerve regeneration in mice following a crush injury.
Topics: Analgesics; Animals; Crush Injuries; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; | 2017 |
Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: involvement of nitric oxide.
Topics: Animals; Antidepressive Agents; Brain; Compulsive Behavior; Depression; Disease Models, Animal; Dose | 2013 |
Developmental hyperoxia alters CNS mechanisms underlying hypoxic ventilatory depression in neonatal rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autonomic Denervation; Central Nervous | 2013 |
TNP-ATP is Beneficial for Treatment of Neonatal Hypoxia-Induced Hypomyelination and Cognitive Decline.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Cognition Disorders; Disease Models, Anima | 2016 |
Alteration of cholinergic, purinergic and sensory neurotransmission in the mouse colon of food allergy model.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Chemokine CCL2; Colon; Disease Models, Animal; Electric | 2008 |
P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo.
Topics: Adenosine Diphosphate; Androstadienes; Animals; Apoptosis; Astrocytes; Brain Injuries; Disease Model | 2009 |
Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Survival; Disease Models, Animal; Extracellular Spa | 2009 |
Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mod | 2009 |
5-HT2 receptors modulate excitatory neurotransmission to cardiac vagal neurons within the nucleus ambiguus evoked during and after hypoxia.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Heart; Hypoxia, Brain; Ketanser | 2009 |
The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production.
Topics: Animals; Apyrase; Cell Movement; Chemokine CXCL2; Chemokines; Disease Models, Animal; Exudates and T | 2010 |
Differential purinergic signaling in bladder sensory neurons of naïve and bladder-inflamed mice.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Cyclophosphamide; Disease Models, Animal; Dogs; Ga | 2010 |
Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Benzoxazoles; Calcium; | 2010 |
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
Topics: Adenosine Triphosphate; Animals; Benzhydryl Compounds; Benzofurans; Cresols; Cystitis; Disease Model | 2010 |
A new function for ATP: activating cardiac sympathetic afferents during myocardial ischemia.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic Fibers; Animals; Cats; | 2010 |
A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury.
Topics: Animals; Contusions; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Neuroprotective A | 2012 |
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; CARD Signaling Adaptor Protein | 2011 |
Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Blood Pressure; Brain Stem; Calcium; Carbenoxolo | 2012 |
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Male; Microgli | 2003 |
Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons.
Topics: Adenosine Triphosphate; Animals; Cell Count; Disease Models, Animal; Dose-Response Relationship, Dru | 2004 |
P2X7 receptor inhibition improves recovery after spinal cord injury.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Benzoxazines; Disease Models, Animal; Electrophysiology; | 2004 |
Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis; Carrageenan; Disea | 2005 |
Alpha-1B adrenoceptors mediate neurogenic constriction in mesenteric arteries of normotensive and DOCA-salt hypertensive mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; D | 2005 |
The co-treatments of vigabatrin and P2X receptor antagonists protect ischemic neuronal cell death in the gerbil hippocampus.
Topics: Adenosine Triphosphatases; Animals; Cell Death; Disease Models, Animal; Drug Therapy, Combination; E | 2006 |
P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Benzenesulfonates; Ca | 2007 |
P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain.
Topics: Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalges | 2007 |
Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats.
Topics: Animals; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Femal | 2008 |
Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension.
Topics: Actins; Adenosine Triphosphate; Angiotensin II; Animals; Arterioles; Blood Pressure; Cell Proliferat | 2008 |
PPADS, a purinergic antagonist reduces Fos expression at spinal cord level in a mouse model of mononeuropathy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Involvement of purinergic P2 receptors in experimental retinal neovascularization.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Mice; M | 2008 |
Modulatory roles of the adenosine triphosphate P2x-purinoceptor in generation of the persistent nociception induced by subcutaneous bee venom injection in the conscious rat.
Topics: Adenosine Triphosphate; Analgesics; Animals; Bee Venoms; Consciousness; Disease Models, Animal; Hind | 2000 |