pyridoxal-isonicotinoyl-hydrazone and Neuroectodermal-Tumors--Primitive--Peripheral

pyridoxal-isonicotinoyl-hydrazone has been researched along with Neuroectodermal-Tumors--Primitive--Peripheral* in 1 studies

Other Studies

1 other study(ies) available for pyridoxal-isonicotinoyl-hydrazone and Neuroectodermal-Tumors--Primitive--Peripheral

Article	Year
Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 1999, Volume: 4, Issue:3 Previous studies have demonstrated that 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and several other aroylhydrazone chelators possess anti-neoplastic activity due to their ability to bind intracellular iron. In this study we have examined the structure and properties of NIH and its FeIII complex in order to obtain further insight into its anti-tumour activity. Two tridentate NIH ligands deprotonate upon coordination to FeIII in a meridional fashion to form a distorted octahedral, high-spin complex. Solution electrochemistry of [Fe(NIH-H)2]+ shows that the trivalent oxidation state is dominant over a wide potential range and that the FeII analogue is not a stable form of this complex. The fact that [Fe(NIH-H)2]+ cannot cycle between the FeII and FeIII states suggests that the production of toxic free-radical species, e.g. OH. or O2.-, is not part of this ligand's cytotoxic action. This suggestion is supported by cell culture experiments demonstrating that the addition of FeIII to NIH prevents its anti-proliferative effect. The chemistry of this chelator and its FeIII complex are discussed in the context of understanding its anti-tumour activity. Topics: Antineoplastic Agents; Cell Division; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Electrochemistry; Humans; Iron; Iron Chelating Agents; Isoniazid; Models, Molecular; Neuroectodermal Tumors, Primitive, Peripheral; Pyridoxal; Structure-Activity Relationship; Temperature; Tumor Cells, Cultured	1999

Article

Year

Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 1999, Volume: 4, Issue:3

Previous studies have demonstrated that 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and several other aroylhydrazone chelators possess anti-neoplastic activity due to their ability to bind intracellular iron. In this study we have examined the structure and properties of NIH and its FeIII complex in order to obtain further insight into its anti-tumour activity. Two tridentate NIH ligands deprotonate upon coordination to FeIII in a meridional fashion to form a distorted octahedral, high-spin complex. Solution electrochemistry of [Fe(NIH-H)2]+ shows that the trivalent oxidation state is dominant over a wide potential range and that the FeII analogue is not a stable form of this complex. The fact that [Fe(NIH-H)2]+ cannot cycle between the FeII and FeIII states suggests that the production of toxic free-radical species, e.g. OH. or O2.-, is not part of this ligand's cytotoxic action. This suggestion is supported by cell culture experiments demonstrating that the addition of FeIII to NIH prevents its anti-proliferative effect. The chemistry of this chelator and its FeIII complex are discussed in the context of understanding its anti-tumour activity.

Topics: Antineoplastic Agents; Cell Division; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Electrochemistry; Humans; Iron; Iron Chelating Agents; Isoniazid; Models, Molecular; Neuroectodermal Tumors, Primitive, Peripheral; Pyridoxal; Structure-Activity Relationship; Temperature; Tumor Cells, Cultured

1999