pyridoxal has been researched along with Pregnancy in 23 studies
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This was a pre-specified substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin®) (n = 131) to placebo (n = 126) in women with nausea and vomiting of pregnancy." | 9.19 | Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2014) |
| "To evaluate the adequacy of maternal pyridoxine supplementation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP + PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3 mg pyridoxine." | 7.70 | Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth. ( Chang, SJ, 1999) |
| ""Perinatal" hypophosphatasia is the most severe form of this inborn error of metabolism, which is characterized by deficient activity of the tissue-nonspecific (liver/bone/kidney) isoenzyme of alkaline phosphatase (ALP) (TNSALP)." | 5.27 | Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. ( Coburn, SP; Cole, FS; Fedde, KN; Mahuren, JD; McCabe, ER; Whyte, MP, 1988) |
| " This was a pre-specified substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin®) (n = 131) to placebo (n = 126) in women with nausea and vomiting of pregnancy." | 5.19 | Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2014) |
| "The delayed-release combination of doxylamine succinate and pyridoxine hydrochloride was the most commonly used antiemetic (Bendectin) approved by FDA for nausea and vomiting of pregnancy (NVP) until its removal of the market in 1983." | 5.14 | Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age. ( Koren, G; Nulman, I, 2009) |
| "To evaluate the adequacy of maternal pyridoxine supplementation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP + PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3 mg pyridoxine." | 3.70 | Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth. ( Chang, SJ, 1999) |
| "The cause of reduced plasma pyridoxal-5'-phosphate (PLP) concentration and the validity of plasma PLP concentration as a vitamin B-6 status indicator during pregnancy are not well understood." | 3.68 | Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ. ( Trumbo, PR; Wang, JW, 1993) |
| " Liver PLP content was also lower during pregnancy, but liver pyridoxamine 5'-phosphate (PMP), kidney PLP and PMP and muscle PLP contents did not change significantly." | 3.67 | Vitamin B-6 metabolism in the pregnant rat: effect of progesterone on the (re)distribution in maternal vitamin B-6 stores. ( Bogaards, JJ; Van den Berg, H, 1987) |
| " Oral bioavailability (BA) was determined through administration of DS-1211 at a 0." | 1.72 | In Vitro and In Vivo Pharmacological Profiles of DS-1211, a Novel Potent, Selective, and Orally Bioavailable Tissue-Nonspecific Alkaline Phosphatase Inhibitor. ( Izumi, M; Miyazaki, S; Soma, K; Watanabe, K; Yamamoto, Y, 2022) |
| ""Perinatal" hypophosphatasia is the most severe form of this inborn error of metabolism, which is characterized by deficient activity of the tissue-nonspecific (liver/bone/kidney) isoenzyme of alkaline phosphatase (ALP) (TNSALP)." | 1.27 | Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. ( Coburn, SP; Cole, FS; Fedde, KN; Mahuren, JD; McCabe, ER; Whyte, MP, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (60.87) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Soma, K | 1 |
| Izumi, M | 1 |
| Yamamoto, Y | 1 |
| Miyazaki, S | 1 |
| Watanabe, K | 1 |
| Matok, I | 1 |
| Clark, S | 1 |
| Caritis, S | 1 |
| Miodovnik, M | 1 |
| Umans, JG | 1 |
| Hankins, G | 1 |
| Mattison, DR | 1 |
| Koren, G | 2 |
| Ueland, PM | 1 |
| Ulvik, A | 1 |
| Rios-Avila, L | 1 |
| Midttun, Ø | 1 |
| Gregory, JF | 1 |
| Nulman, I | 1 |
| Takimoto, H | 1 |
| Hayashi, F | 1 |
| Kusama, K | 1 |
| Kato, N | 1 |
| Yoshiike, N | 1 |
| Toba, M | 1 |
| Ishibashi, T | 1 |
| Miyasaka, N | 1 |
| Kubota, T | 1 |
| Wilson, RG | 1 |
| Davis, RE | 1 |
| Smith, GP | 1 |
| Anderson, BB | 1 |
| Peters, TJ | 1 |
| Landschulz, W | 2 |
| Thesleff, I | 1 |
| Ekblom, P | 2 |
| Shane, B | 1 |
| Tsuge, H | 1 |
| Maeno, M | 1 |
| Nagae, K | 1 |
| Nohisa, C | 1 |
| Hayakawa, T | 1 |
| Trumbo, PR | 1 |
| Wang, JW | 1 |
| Chang, SJ | 1 |
| Leibman, D | 1 |
| Furth-Walker, D | 1 |
| Smolen, A | 1 |
| Compton, MM | 1 |
| Cidlowski, JA | 1 |
| Whyte, MP | 1 |
| Mahuren, JD | 1 |
| Fedde, KN | 1 |
| Cole, FS | 1 |
| McCabe, ER | 1 |
| Coburn, SP | 1 |
| Barnard, HC | 1 |
| de Kock, JJ | 1 |
| Vermaak, WJ | 1 |
| Potgieter, GM | 1 |
| Van den Berg, H | 1 |
| Bogaards, JJ | 1 |
| Loo, YH | 2 |
| Mack, K | 1 |
| Gaynor, R | 1 |
| Dempsey, WB | 1 |
| Driskell, JA | 2 |
| Chuang, SL | 1 |
| Strickland, LA | 1 |
| Poon, CH | 1 |
| Foshee, DP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445] | Phase 3 | 280 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)
| Intervention | PUQE Score (Mean) |
|---|---|
| Diclectin® | -4.8 |
| Placebo | -3.9 |
3 reviews available for pyridoxal and Pregnancy
| Article | Year |
|---|---|
Direct and Functional Biomarkers of Vitamin B6 Status.
Topics: Amino Acids; Biomarkers; Body Mass Index; Female; Health Status; Humans; Infant; Infant, Newborn; In | 2015 |
Clinical chemistry of vitamin B6.
Topics: Animals; Biological Assay; Biological Availability; Biological Transport; Chemical Phenomena; Chemis | 1983 |
Vitamin B6 and glucocorticoid action.
Topics: Animals; Borohydrides; Caseins; Cell Line; Cell Nucleus; Centrifugation, Density Gradient; Chemical | 1986 |
2 trials available for pyridoxal and Pregnancy
| Article | Year |
|---|---|
Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug Combina | 2014 |
Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age.
Topics: Adult; Antiemetics; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Pr | 2009 |
18 other studies available for pyridoxal and Pregnancy
| Article | Year |
|---|---|
In Vitro and In Vivo Pharmacological Profiles of DS-1211, a Novel Potent, Selective, and Orally Bioavailable Tissue-Nonspecific Alkaline Phosphatase Inhibitor.
Topics: Alkaline Phosphatase; Animals; Diphosphates; Enzyme Inhibitors; Female; Haplorhini; Humans; Isoenzym | 2022 |
Elevated maternal serum folate in the third trimester and reduced fetal growth: a longitudinal study.
Topics: Adult; Biomarkers; Birth Weight; Body Height; Dietary Supplements; Female; Fetal Development; Folic | 2011 |
Levels and subcellular localisation of pyridoxal and pyridoxal phosphate in human polymorphonuclear leukocytes and their relationship to alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Cell Fractionation; Centrifugation, Density Gradient; Cytosol; Female; Humans; | 1983 |
A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation.
Topics: Animals; Cell Differentiation; Cell Division; DNA Replication; Embryo, Mammalian; Female; Iron Chela | 1984 |
Vitamin B-6 metabolism and turnover in the ethanol-fed rat.
Topics: Alcoholism; Animals; Body Weight; Brain; Female; Humans; Liver; Male; Organ Size; Organophosphorus C | 1982 |
Change in blood levels of vitamin B-6 derivatives in pregnant and lactating rats.
Topics: Animals; Chromatography, High Pressure Liquid; Erythrocytes; Female; Lactation; Nutritional Status; | 1994 |
Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ.
Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Chromatography, High Pressure Liquid; Eryt | 1993 |
Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth.
Topics: Dietary Supplements; Female; Fetal Blood; Humans; Infant, Newborn; Nutritional Status; Pregnancy; Py | 1999 |
Vitamin B-6 metabolic enzymes in blood and placenta of pregnant mice.
Topics: Alkaline Phosphatase; Animals; Erythrocytes; Female; Hydrogen-Ion Concentration; Intestines; Kidney; | 1990 |
Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase.
Topics: Alkaline Phosphatase; Female; Fetal Death; Humans; Hypophosphatasia; Infant, Newborn; Male; Pregnanc | 1988 |
A new perspective in the assessment of vitamin B-6 nutritional status during pregnancy in humans.
Topics: Adolescent; Adult; Black People; Female; Humans; Nutritional Status; Pregnancy; Pyridoxal; Pyridoxal | 1987 |
Vitamin B-6 metabolism in the pregnant rat: effect of progesterone on the (re)distribution in maternal vitamin B-6 stores.
Topics: Animals; Female; Kidney; Liver; Muscles; Organ Size; Ovariectomy; Pregnancy; Pregnancy, Animal; Prog | 1987 |
Iron delivery during proliferation and differentiation of kidney tubules.
Topics: Animals; Cell Differentiation; Cell Division; Female; Hemin; Iron; Isoniazid; Kidney Tubules; Mice; | 1985 |
Effect of hyperphenylalaninemia on vitamin B 6 metabolism in developing rat brain.
Topics: Animals; Brain; Carbon Isotopes; Chromatography, Ion Exchange; Female; Fenclonine; Humans; Injection | 1972 |
Vitamin B 6 enzymes in normal and pre-eclamptic human placentae.
Topics: Alcohol Oxidoreductases; Ammonium Sulfate; Chemical Precipitation; Eclampsia; Female; Humans; Phosph | 1972 |
Relationship between glutamate decarboxylase activities in brains and the vitamin B-6 requirement of male rats.
Topics: Alanine Transaminase; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Brain; Carbo | 1974 |
Serotonin deficiency in experimental hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Animals; Biphenyl Compounds; Brain; Carbon Radioisotopes; Carboxy-Lyases; Dopa | 1974 |
The vitamin B 6 requirement of the male rat as determined by behavioral patterns, brain pyridoxal phosphate and nucleic acid composition and erythrocyte alanine aminotransferase activity.
Topics: Age Factors; Alanine Transaminase; Animals; Behavior, Animal; Brain; DNA; Dose-Response Relationship | 1973 |