pyridoxal has been researched along with Iron Overload in 7 studies
Iron Overload: An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxal isonicotinoyl hydrazone (PIH) is a tridentate Fe-chelating agent that shows high Fe chelation efficacy both in vitro in cell culture models and also in vivo in rats and mice." | 6.40 | Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. ( Ponka, P; Richardson, DR, 1998) |
| "Pyridoxal isonicotinoyl hydrazone (PIH) is a tridentate Fe-chelating agent that shows high Fe chelation efficacy both in vitro in cell culture models and also in vivo in rats and mice." | 2.40 | Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. ( Ponka, P; Richardson, DR, 1998) |
| "Iron (Fe) chelation therapy was initially designed to alleviate the toxic effects of excess Fe evident in Fe-overload diseases." | 1.34 | Future of toxicology--iron chelators and differing modes of action and toxicity: the changing face of iron chelation therapy. ( Kalinowski, DS; Richardson, DR, 2007) |
| "Pyridoxal isonicotinoyl hydrazone (PIH) is a new tridentate Fe-chelating agent that should be very promising in many pathological states resulting from both an iron-overload and formation of free radicals." | 1.31 | Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits. ( Adamcová, M; Gersl, V; Hrdina, R; Klimtová, I; Machácková, J; Pelouch, V; Ponka, P; Simůnek, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kovacevic, Z | 1 |
| Yu, Y | 1 |
| Richardson, DR | 4 |
| Adamcová, M | 1 |
| Machácková, J | 1 |
| Gersl, V | 1 |
| Pelouch, V | 1 |
| Simůnek, T | 1 |
| Klimtová, I | 1 |
| Hrdina, R | 1 |
| Ponka, P | 4 |
| Buss, JL | 1 |
| Hermes-Lima, M | 1 |
| Hershko, CM | 1 |
| Link, GM | 1 |
| Konijn, AM | 1 |
| Cabantchik, ZI | 1 |
| Kalinowski, DS | 1 |
3 reviews available for pyridoxal and Iron Overload
| Article | Year |
|---|---|
Pyridoxal isonicotinoyl hydrazone and its analogues.
Topics: Animals; Antioxidants; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Iron; Iron Chelati | 2002 |
Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease.
Topics: Animals; Iron Chelating Agents; Iron Overload; Isoniazid; Mice; Pyridoxal; Rats | 1998 |
Orally effective iron chelators for the treatment of iron overload disease: the case for a further look at pyridoxal isonicotinoyl hydrazone and its analogs.
Topics: Administration, Oral; Animals; Deferiprone; Ferritins; Iron; Iron Chelating Agents; Iron Overload; I | 1998 |
4 other studies available for pyridoxal and Iron Overload
| Article | Year |
|---|---|
Chelators to the rescue: different horses for different courses!
Topics: Aldehydes; Animals; Deferoxamine; Humans; Hydrazones; Iron Chelating Agents; Iron Overload; Isoniazi | 2011 |
Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits.
Topics: Animals; Cell Fractionation; Cytosol; Iron Chelating Agents; Iron Overload; Isoniazid; Male; Myocard | 2002 |
Iron chelation therapy.
Topics: Administration, Oral; Benzoates; beta-Thalassemia; Chelation Therapy; Chemical and Drug Induced Live | 2005 |
Future of toxicology--iron chelators and differing modes of action and toxicity: the changing face of iron chelation therapy.
Topics: Chelation Therapy; Humans; Hydrazones; Iron Chelating Agents; Iron Overload; Isoniazid; Pyridines; P | 2007 |