pyridoxal has been researched along with Hypophosphatasia in 3 studies
Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the utility of serum pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) as a diagnostic marker of hypophosphatasia (HPP) and an indicator of the effect of, and patient compliance with, enzyme replacement therapy (ERT), we measured PLP, PL, and PA concentrations in serum samples from HPP patients with and without ERT." | 7.88 | Pyridoxal 5'-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy. ( Akiyama, T; Harada, D; Kitanaka, S; Kobayashi, D; Kobayashi, K; Kubota, T; Matsunami, K; Michigami, T; Mitani, Y; Namba, N; Noda, M; Ogawa, E; Ozono, K; Sugiyama, Y; Suzuki, A; Takeyari, S; Takishima, S; Uematsu, M; Utoyama, M, 2018) |
| ""Perinatal" hypophosphatasia is the most severe form of this inborn error of metabolism, which is characterized by deficient activity of the tissue-nonspecific (liver/bone/kidney) isoenzyme of alkaline phosphatase (ALP) (TNSALP)." | 5.27 | Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. ( Coburn, SP; Cole, FS; Fedde, KN; Mahuren, JD; McCabe, ER; Whyte, MP, 1988) |
| "To investigate the utility of serum pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) as a diagnostic marker of hypophosphatasia (HPP) and an indicator of the effect of, and patient compliance with, enzyme replacement therapy (ERT), we measured PLP, PL, and PA concentrations in serum samples from HPP patients with and without ERT." | 3.88 | Pyridoxal 5'-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy. ( Akiyama, T; Harada, D; Kitanaka, S; Kobayashi, D; Kobayashi, K; Kubota, T; Matsunami, K; Michigami, T; Mitani, Y; Namba, N; Noda, M; Ogawa, E; Ozono, K; Sugiyama, Y; Suzuki, A; Takeyari, S; Takishima, S; Uematsu, M; Utoyama, M, 2018) |
| ""Perinatal" hypophosphatasia is the most severe form of this inborn error of metabolism, which is characterized by deficient activity of the tissue-nonspecific (liver/bone/kidney) isoenzyme of alkaline phosphatase (ALP) (TNSALP)." | 1.27 | Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. ( Coburn, SP; Cole, FS; Fedde, KN; Mahuren, JD; McCabe, ER; Whyte, MP, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akiyama, T | 1 |
| Kubota, T | 1 |
| Ozono, K | 1 |
| Michigami, T | 1 |
| Kobayashi, D | 1 |
| Takeyari, S | 1 |
| Sugiyama, Y | 1 |
| Noda, M | 1 |
| Harada, D | 1 |
| Namba, N | 1 |
| Suzuki, A | 1 |
| Utoyama, M | 1 |
| Kitanaka, S | 1 |
| Uematsu, M | 1 |
| Mitani, Y | 1 |
| Matsunami, K | 1 |
| Takishima, S | 1 |
| Ogawa, E | 1 |
| Kobayashi, K | 1 |
| Narisawa, S | 1 |
| Wennberg, C | 1 |
| Millán, JL | 1 |
| Whyte, MP | 1 |
| Mahuren, JD | 1 |
| Fedde, KN | 1 |
| Cole, FS | 1 |
| McCabe, ER | 1 |
| Coburn, SP | 1 |
3 other studies available for pyridoxal and Hypophosphatasia
| Article | Year |
|---|---|
Pyridoxal 5'-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Child; Child, Preschool; Chromatography, High Pressure Liqu | 2018 |
Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization.
Topics: Abnormalities, Multiple; Alkaline Phosphatase; Animals; Calcification, Physiologic; Cell Culture Tec | 2001 |
Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase.
Topics: Alkaline Phosphatase; Female; Fetal Death; Humans; Hypophosphatasia; Infant, Newborn; Male; Pregnanc | 1988 |