pyridostatin and Laryngeal-Neoplasms

pyridostatin has been researched along with Laryngeal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for pyridostatin and Laryngeal-Neoplasms

Article	Year
Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog. Bioorganic & medicinal chemistry letters, 2016, Apr-01, Volume: 26, Issue:7 The G-quadruplexes located in the P1 promoter of B-cell lymphoma-2 (Bcl-2) gene are implicated to regulate Bcl-2 expression. Here, we designed a new pyridostatin analog named PDF, which exhibited high specificity and stabilizing effect toward G-quadruplexes. The luciferase assay demonstrated that PDF could significantly suppress Bcl-2 transcriptional activation in human laryngeal squamous carcinoma cells (Hep-2) cells. Besides, PDF also induced cell apoptosis in vitro assays. These results provide an excellent G-quadruplex specific ligand as an efficient Bcl-2 inhibitor. These results also implicate that PDF may be a potential anticancer drug to head neck cancer. Topics: Aminoquinolines; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA; Down-Regulation; G-Quadruplexes; Humans; Laryngeal Neoplasms; Larynx; Picolinic Acids; Proto-Oncogene Proteins c-bcl-2; Transcriptional Activation	2016

Article

Year

Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog.

Bioorganic & medicinal chemistry letters, 2016, Apr-01, Volume: 26, Issue:7

The G-quadruplexes located in the P1 promoter of B-cell lymphoma-2 (Bcl-2) gene are implicated to regulate Bcl-2 expression. Here, we designed a new pyridostatin analog named PDF, which exhibited high specificity and stabilizing effect toward G-quadruplexes. The luciferase assay demonstrated that PDF could significantly suppress Bcl-2 transcriptional activation in human laryngeal squamous carcinoma cells (Hep-2) cells. Besides, PDF also induced cell apoptosis in vitro assays. These results provide an excellent G-quadruplex specific ligand as an efficient Bcl-2 inhibitor. These results also implicate that PDF may be a potential anticancer drug to head neck cancer.

Topics: Aminoquinolines; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA; Down-Regulation; G-Quadruplexes; Humans; Laryngeal Neoplasms; Larynx; Picolinic Acids; Proto-Oncogene Proteins c-bcl-2; Transcriptional Activation

2016