pyridostatin and Enterovirus-Infections

Rhinoviruses (RVs) are the main cause of recurrent infections with rather mild symptoms characteristic of the common cold. Nevertheless, RVs give rise to enormous numbers of absences from work and school and may become life-threatening in particular settings. Vaccination is jeopardised by the large number of serotypes eliciting only poorly cross-neutralising antibodies. Conversely, antivirals developed over the years failed FDA approval because of a low efficacy and/or side effects. RV species A, B, and C are now included in the fifteen species of the genus

Topics: Aminoquinolines; Animals; Antiviral Agents; Capsid; Capsid Proteins; Enterovirus; Enterovirus Infections; Genome, Viral; Humans; Picolinic Acids; Poliovirus; Rhinovirus; RNA, Viral; Viral Nonstructural Proteins; Viral Proteins