pyridine has been researched along with Parkinson Disease in 4 studies
azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as the accumulation of intraneuronal proteinaceous inclusions known as Lewy bodies and Lewy neurites." | 1.72 | The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains. ( Manglano-Artuñedo, Z; Outeiro, TF; Peña-Díaz, S; Pinheiro, F; Pujols, J; Santos, J; Vasili, E; Ventura, S, 2022) |
| "Impulsive-compulsive disorders in Parkinson's disease patients have been described as behavioural or substance addictions including pathological gambling or compulsive medication use of dopamine replacement therapy." | 1.46 | Striatal changes underlie MPEP-mediated suppression of the acquisition and expression of pramipexole-induced place preference in an alpha-synuclein rat model of Parkinson's disease. ( Dardou, D; Durif, F; Fleurance, R; Gryshkova, V; Hafidi, A; Loiodice, S; McGhan, P; Nogueira da Costa, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peña-Díaz, S | 1 |
| Pujols, J | 1 |
| Vasili, E | 1 |
| Pinheiro, F | 1 |
| Santos, J | 1 |
| Manglano-Artuñedo, Z | 1 |
| Outeiro, TF | 1 |
| Ventura, S | 1 |
| Loiodice, S | 1 |
| McGhan, P | 1 |
| Gryshkova, V | 1 |
| Fleurance, R | 1 |
| Dardou, D | 1 |
| Hafidi, A | 1 |
| Nogueira da Costa, A | 1 |
| Durif, F | 1 |
| Fujita, M | 1 |
| Ichise, M | 1 |
| Zoghbi, SS | 1 |
| Liow, JS | 1 |
| Ghose, S | 1 |
| Vines, DC | 1 |
| Sangare, J | 1 |
| Lu, JQ | 1 |
| Cropley, VL | 1 |
| Iida, H | 1 |
| Kim, KM | 1 |
| Cohen, RM | 1 |
| Bara-Jimenez, W | 1 |
| Ravina, B | 1 |
| Innis, RB | 1 |
| BERGER, FM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quantification of Cerebral Cholinergic Function in Patients With Parkinson´s Disease by Means of Nuclear Medicine Methods[NCT01003535] | 25 participants (Actual) | Observational | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for pyridine and Parkinson Disease
| Article | Year |
|---|---|
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.
Topics: alpha-Synuclein; Amyloid; Humans; Lewy Bodies; Neuroprotective Agents; Parkinson Disease; Polymeriza | 2022 |
Striatal changes underlie MPEP-mediated suppression of the acquisition and expression of pramipexole-induced place preference in an alpha-synuclein rat model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonis | 2017 |
Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease.
Topics: Aged; Azetidines; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Parkinson Disease; Pyridi | 2006 |
The treatment of paralysis agitans with thephorin.
Topics: Colon; Digestive System Surgical Procedures; Intestines; Parkinson Disease; Pyridines | 1949 |