pyridine has been researched along with Disease Models, Animal in 21 studies
azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously showed that 1-methylnicotinamide (1-MNA) and its analog 1,4-dimethylpyridine (1,4-DMP) could inhibit the formation of lung metastases and enhance the efficacy of cyclophosphamide-based chemotherapy in the model of spontaneously metastasizing 4T1 mouse mammary gland tumors." | 3.85 | The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice. ( Chlopicki, S; Denslow, A; Gebicki, J; Maciejewska, M; Marcinek, A; Nowak, M; Switalska, M; Wietrzyk, J, 2017) |
| " One promising pyridine derivative (49) displayed 100% oral bioavailability in mice and delivered a 96% parasite burden reduction when dosed at 50 mg/kg in a Leishmania donovani mouse model of visceral leishmaniasis." | 1.62 | Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal. ( Braillard, S; Chatelain, E; Cooper, CB; Denny, WA; Franzblau, SG; Gupta, S; Launay, D; Ma, Z; Maes, L; Marshall, AJ; O'Connor, PD; Thompson, AM; Wan, B; Yardley, V, 2021) |
| "SK94 and SK126 were administered to the Behcet's disease-like mice for five consecutive days and SK94 improved in five out of six mice (83%), while it only improved in one out of nine mice (11%) in the pH 1." | 1.37 | Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model. ( Bang, D; Choi, B; Kim, J; Lee, ES; Sohn, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 17 (80.95) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Thompson, AM | 1 |
| O'Connor, PD | 1 |
| Marshall, AJ | 1 |
| Yardley, V | 1 |
| Maes, L | 1 |
| Gupta, S | 1 |
| Launay, D | 1 |
| Braillard, S | 1 |
| Chatelain, E | 1 |
| Wan, B | 1 |
| Franzblau, SG | 1 |
| Ma, Z | 1 |
| Cooper, CB | 1 |
| Denny, WA | 1 |
| Yin, C | 1 |
| Wang, Z | 1 |
| Ding, X | 1 |
| Chen, X | 2 |
| Wang, J | 1 |
| Yang, E | 1 |
| Wang, W | 1 |
| Martin, LL | 1 |
| Sun, D | 2 |
| Zhang, H | 2 |
| Wu, C | 1 |
| Zhang, Z | 1 |
| Jiang, X | 1 |
| Qin, HL | 1 |
| Tang, W | 1 |
| Zhang, Y | 2 |
| Wu, Y | 1 |
| Qi, H | 1 |
| Xiao, J | 1 |
| Gong, H | 1 |
| Xu, E | 1 |
| Li, S | 1 |
| Ma, D | 1 |
| Wang, Y | 1 |
| Li, W | 1 |
| Shen, H | 1 |
| Kadayat, TM | 1 |
| Banskota, S | 1 |
| Bist, G | 1 |
| Gurung, P | 1 |
| Magar, TBT | 1 |
| Shrestha, A | 1 |
| Kim, JA | 1 |
| Lee, ES | 2 |
| Shi, Y | 1 |
| Wang, Q | 1 |
| Rong, J | 1 |
| Ren, J | 1 |
| Song, X | 1 |
| Fan, X | 1 |
| Shen, M | 1 |
| Xia, Y | 1 |
| Wang, N | 1 |
| Liu, Z | 1 |
| Hu, Q | 1 |
| Ye, T | 1 |
| Yu, L | 1 |
| Kato, Y | 1 |
| Kawasaki, M | 1 |
| Nigo, T | 1 |
| Nakamura, S | 1 |
| Fusano, A | 1 |
| Teranishi, Y | 1 |
| Ito, MN | 1 |
| Sumiyoshi, T | 1 |
| Ha, TH | 1 |
| Ryu, H | 1 |
| Kim, SE | 1 |
| Kim, HS | 1 |
| Ann, J | 1 |
| Tran, PT | 1 |
| Hoang, VH | 1 |
| Son, K | 1 |
| Cui, M | 1 |
| Choi, S | 1 |
| Blumberg, PM | 1 |
| Frank, R | 1 |
| Bahrenberg, G | 1 |
| Schiene, K | 1 |
| Christoph, T | 1 |
| Frormann, S | 1 |
| Lee, J | 2 |
| Adam, R | 1 |
| Bilbao-Ramos, P | 1 |
| López-Molina, S | 1 |
| Abarca, B | 1 |
| Ballesteros, R | 1 |
| González-Rosende, ME | 1 |
| Dea-Ayuela, MA | 1 |
| Alzuet-Piña, G | 1 |
| Chen, CJ | 2 |
| Bando, K | 2 |
| Ashino, H | 2 |
| Taguchi, K | 2 |
| Shiraishi, H | 2 |
| Shima, K | 2 |
| Fujimoto, O | 2 |
| Kitamura, C | 2 |
| Morimoto, Y | 1 |
| Kasahara, H | 2 |
| Minamizawa, T | 2 |
| Jiang, C | 2 |
| Zhang, MR | 2 |
| Suhara, T | 2 |
| Higuchi, M | 2 |
| Yamada, K | 2 |
| Ji, B | 2 |
| Matsushima, S | 1 |
| Uchida, K | 1 |
| Nakahara, Y | 1 |
| Ono, M | 1 |
| Tokunaga, M | 1 |
| Nam, M | 1 |
| Kim, T | 1 |
| Kwak, J | 1 |
| Seo, SH | 1 |
| Ko, MK | 1 |
| Lim, EJ | 1 |
| Min, SJ | 1 |
| Cho, YS | 1 |
| Keum, G | 1 |
| Baek, DJ | 1 |
| Pae, AN | 1 |
| Fu, CW | 1 |
| Hsieh, YJ | 1 |
| Chang, TT | 1 |
| Chen, CL | 1 |
| Yang, CY | 1 |
| Liao, A | 1 |
| Hsiao, PW | 1 |
| Li, WS | 1 |
| Kudryashov, NV | 1 |
| Kalinina, TS | 1 |
| Zhmurenko, LA | 1 |
| Voronina, TA | 1 |
| Lauver, DA | 1 |
| Wang, H | 1 |
| Hollenberg, PF | 1 |
| Chen, YE | 1 |
| Osawa, Y | 1 |
| Eitzman, DT | 1 |
| Denslow, A | 1 |
| Switalska, M | 1 |
| Nowak, M | 1 |
| Maciejewska, M | 1 |
| Chlopicki, S | 1 |
| Marcinek, A | 1 |
| Gebicki, J | 1 |
| Wietrzyk, J | 1 |
| Tajima, H | 1 |
| Honda, T | 1 |
| Kawashima, K | 1 |
| Sasabuchi, Y | 1 |
| Yamamoto, M | 1 |
| Ban, M | 1 |
| Okamoto, K | 1 |
| Inoue, K | 1 |
| Inaba, T | 1 |
| Takeno, Y | 1 |
| Aono, H | 1 |
| Choi, B | 1 |
| Kim, J | 1 |
| Bang, D | 1 |
| Sohn, S | 1 |
| Trotter, BW | 1 |
| Nanda, KK | 1 |
| Burgey, CS | 1 |
| Potteiger, CM | 1 |
| Deng, JZ | 1 |
| Green, AI | 1 |
| Hartnett, JC | 1 |
| Kett, NR | 1 |
| Wu, Z | 1 |
| Henze, DA | 1 |
| Della Penna, K | 1 |
| Desai, R | 1 |
| Leitl, MD | 1 |
| Lemaire, W | 1 |
| White, RB | 1 |
| Yeh, S | 1 |
| Urban, MO | 1 |
| Kane, SA | 1 |
| Hartman, GD | 1 |
| Bilodeau, MT | 1 |
| Le, U | 1 |
| Melancon, BJ | 1 |
| Bridges, TM | 1 |
| Vinson, PN | 1 |
| Utley, TJ | 1 |
| Lamsal, A | 1 |
| Rodriguez, AL | 1 |
| Venable, D | 1 |
| Sheffler, DJ | 1 |
| Jones, CK | 1 |
| Blobaum, AL | 1 |
| Wood, MR | 1 |
| Daniels, JS | 1 |
| Conn, PJ | 1 |
| Niswender, CM | 1 |
| Lindsley, CW | 1 |
| Hopkins, CR | 1 |
1 review available for pyridine and Disease Models, Animal
| Article | Year |
|---|---|
Pyridine.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Environmental Exposure; Female; | 2000 |
20 other studies available for pyridine and Disease Models, Animal
| Article | Year |
|---|---|
Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal.
Topics: Animals; Antiprotozoal Agents; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; | 2021 |
Crystalline ruthenium polypyridine nanoparticles: a targeted treatment of bacterial infection with multifunctional antibacterial, adhesion and surface-anchoring photosensitizer properties.
Topics: Animals; Anti-Bacterial Agents; Bacteremia; Bacterial Adhesion; Coordination Complexes; Disease Mode | 2021 |
Novel Pyridine-Containing Sultones: Structure-Activity Relationship and Biological Evaluation as Selective AChE Inhibitors for the Treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cell Survival; C | 2021 |
A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.
Topics: Animals; Asthma; Cell Migration Inhibition; Cell Survival; Disease Models, Animal; HEK293 Cells; Hum | 2017 |
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Colitis; Dise | 2018 |
Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis.
Topics: Animals; Cell Survival; Cells, Cultured; Concanavalin A; Disease Models, Animal; Dose-Response Relat | 2019 |
Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Mod | 2013 |
TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides.
Topics: Amides; Analgesics; Animals; Benzeneacetamides; Binding Sites; Disease Models, Animal; Humans; Mice; | 2013 |
Triazolopyridyl ketones as a novel class of antileishmanial agents. DNA binding and BSA interaction.
Topics: Animals; Antiprotozoal Agents; Binding, Competitive; Cattle; Cell Line; Cell Survival; Disease Model | 2014 |
Biological evaluation of the radioiodinated imidazo[1,2-a]pyridine derivative DRK092 for amyloid-β imaging in mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Brain; Disease Models, Animal; H | 2014 |
In vivo SPECT imaging of amyloid-β deposition with radioiodinated imidazo[1,2-a]pyridine derivative DRM106 in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Humans; Imidazoles | 2015 |
Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.
Topics: Administration, Oral; Analgesics; Animals; Cells, Cultured; Disease Models, Animal; Drug Discovery; | 2015 |
Anticancer efficacy of unique pyridine-based tetraindoles.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Disease Models, Animal; Dose-Response | 2015 |
Anticompulsive Activity of a New Pyrazolo[C]Pyridine Derivative GIZh-72 under Conditions of Unpredictable Chronic Mild Stress.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Disease Models, Animal; Male; Mice; Mice, Inbred C57 | 2016 |
Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis.
Topics: Animals; Arteries; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Mice; Mice, Inbred C57B | 2016 |
The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Disease Models, Animal; D | 2017 |
Pyridylmethylthio derivatives as VEGF inhibitors. Part 1.
Topics: Anilides; Animals; Arthritis, Experimental; Cell Line; Choroidal Neovascularization; Disease Models, | 2010 |
Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model.
Topics: Administration, Oral; Animals; Behcet Syndrome; Cell Adhesion Molecules; Cell Line; Disease Models, | 2011 |
Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Freund's Adjuvant; Humans; Hyperalgesia; Pyridines; Rat | 2011 |
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Topics: Allosteric Regulation; Amides; Animals; Brain; Cholinergic Agents; Disease Models, Animal; Drug Eval | 2013 |