pyridine has been researched along with Alzheimer Disease in 15 studies
azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether odor detection sensitivity for pyridine, suggested by previous research not to be affected, is impaired in Alzheimer disease (AD) and whether an association exists between odor threshold and both degree of dementia and rate of dementia progression in AD." | 7.69 | Olfactory dysfunction for pyridine and dementia progression in Alzheimer disease. ( Almkvist, O; Berglund, B; Nordin, S; Wahlund, LO, 1997) |
| "To investigate whether odor detection sensitivity for pyridine, suggested by previous research not to be affected, is impaired in Alzheimer disease (AD) and whether an association exists between odor threshold and both degree of dementia and rate of dementia progression in AD." | 3.69 | Olfactory dysfunction for pyridine and dementia progression in Alzheimer disease. ( Almkvist, O; Berglund, B; Nordin, S; Wahlund, LO, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 9 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jakusch, T | 1 |
| Hassoon, AA | 1 |
| Kiss, T | 1 |
| Esmaeili, S | 1 |
| Ghobadi, N | 1 |
| Akbari, V | 1 |
| Moradi, S | 1 |
| Shahlaie, M | 1 |
| Ghobadi, S | 1 |
| Jalalvand, AR | 1 |
| Amani, M | 1 |
| Khodarahmi, R | 1 |
| Sekioka, R | 1 |
| Honda, S | 1 |
| Honjo, E | 1 |
| Suzuki, T | 1 |
| Akashiba, H | 1 |
| Mitani, Y | 1 |
| Yamasaki, S | 1 |
| Jiang, X | 2 |
| Wang, Y | 2 |
| Liu, C | 1 |
| Xing, C | 1 |
| Lyu, W | 1 |
| Wang, S | 1 |
| Li, Q | 1 |
| Chen, T | 1 |
| Chen, Y | 1 |
| Feng, F | 1 |
| Liu, W | 1 |
| Sun, H | 1 |
| Nakahara, K | 1 |
| Mitsuoka, Y | 1 |
| Kasuya, S | 1 |
| Yamamoto, T | 1 |
| Yamamoto, S | 1 |
| Ito, H | 1 |
| Kido, Y | 1 |
| Kusakabe, KI | 1 |
| Babaee, S | 1 |
| Chehardoli, G | 1 |
| Akbarzadeh, T | 1 |
| Zolfigol, MA | 1 |
| Mahdavi, M | 1 |
| Rastegari, A | 1 |
| Homayouni Moghadam, F | 1 |
| Najafi, Z | 1 |
| Zhang, H | 1 |
| Wu, C | 1 |
| Chen, X | 1 |
| Zhang, Z | 1 |
| Qin, HL | 1 |
| Tang, W | 1 |
| Wall, BJ | 1 |
| Will, MF | 1 |
| Yawson, GK | 1 |
| Bothwell, PJ | 1 |
| Platt, DC | 1 |
| Apuzzo, CF | 1 |
| Jones, MA | 1 |
| Ferrence, GM | 1 |
| Webb, MI | 1 |
| Almeida, MP | 1 |
| Kock, FVC | 1 |
| de Jesus, HCR | 1 |
| Carlos, RM | 1 |
| Venâncio, T | 1 |
| Zhu, Z | 1 |
| Yang, T | 1 |
| Zhang, L | 1 |
| Liu, L | 1 |
| Yin, E | 1 |
| Zhang, C | 1 |
| Guo, Z | 1 |
| Xu, C | 1 |
| Wang, X | 1 |
| Chen, CJ | 2 |
| Bando, K | 2 |
| Ashino, H | 2 |
| Taguchi, K | 2 |
| Shiraishi, H | 2 |
| Shima, K | 2 |
| Fujimoto, O | 2 |
| Kitamura, C | 2 |
| Morimoto, Y | 1 |
| Kasahara, H | 2 |
| Minamizawa, T | 2 |
| Jiang, C | 2 |
| Zhang, MR | 2 |
| Suhara, T | 2 |
| Higuchi, M | 2 |
| Yamada, K | 2 |
| Ji, B | 2 |
| Matsushima, S | 1 |
| Uchida, K | 1 |
| Nakahara, Y | 1 |
| Ono, M | 1 |
| Tokunaga, M | 1 |
| Ono, K | 1 |
| Hasegawa, K | 1 |
| Yamada, M | 1 |
| Naiki, H | 1 |
| Salomon, AR | 1 |
| Marcinowski, KJ | 1 |
| Friedland, RP | 1 |
| Zagorski, MG | 1 |
| Nordin, S | 1 |
| Almkvist, O | 1 |
| Berglund, B | 1 |
| Wahlund, LO | 1 |
15 other studies available for pyridine and Alzheimer Disease
| Article | Year |
|---|---|
Characterization of copper(II) specific pyridine containing ligands: Potential metallophores for Alzheimer's disease therapy.
Topics: Acetamides; Alzheimer Disease; Amides; Amyloid beta-Peptides; Copper; Electron Spin Resonance Spectr | 2022 |
Pyridine-2,3-dicarboxylate, quinolinic acid, induces 1N4R Tau amyloid aggregation in vitro: Another evidence for the detrimental effect of the inescapable endogenous neurotoxin.
Topics: Alzheimer Disease; Amyloid; Humans; Kynurenine; Neurotoxins; Protein Aggregates; Pyridines; Quinolin | 2020 |
Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases | 2020 |
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug | 2021 |
Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Ac | 2021 |
Design, Synthesis, and Molecular Docking of Some Novel Tacrine Based Cyclopentapyranopyridine- and Tetrahydropyranoquinoline-Kojic Acid Derivatives as Anti-Acetylcholinesterase Agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; | 2021 |
Novel Pyridine-Containing Sultones: Structure-Activity Relationship and Biological Evaluation as Selective AChE Inhibitors for the Treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cell Survival; C | 2021 |
Importance of Hydrogen Bonding: Structure-Activity Relationships of Ruthenium(III) Complexes with Pyridine-Based Ligands for Alzheimer's Disease Therapy.
Topics: Alzheimer Disease; Animals; Cell Line, Tumor; Cell Survival; Coordination Complexes; Dose-Response R | 2021 |
Probing the acetylcholinesterase inhibitory activity of a novel Ru(II) polypyridyl complex and the supramolecular interaction by (STD)-NMR.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Coordination Complexes; Humans; | 2021 |
Inhibiting Aβ toxicity in Alzheimer's disease by a pyridine amine derivative.
Topics: Alzheimer Disease; Amines; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Dose-Response Rel | 2019 |
Biological evaluation of the radioiodinated imidazo[1,2-a]pyridine derivative DRK092 for amyloid-β imaging in mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Brain; Disease Models, Animal; H | 2014 |
In vivo SPECT imaging of amyloid-β deposition with radioiodinated imidazo[1,2-a]pyridine derivative DRM106 in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Humans; Imidazoles | 2015 |
Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Culture Techniques; Dose-Response Relationship, Drug; Huma | 2002 |
Nicotine inhibits amyloid formation by the beta-peptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloidosis; Chemical Precipitation; | 1996 |
Olfactory dysfunction for pyridine and dementia progression in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Humans; Male; Middle Aged; Odorants; Pyridines; | 1997 |