pyrazolopyridine has been researched along with Venous-Thrombosis* in 1 studies
1 other study(ies) available for pyrazolopyridine and Venous-Thrombosis
| Article | Year |
|---|---|
Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity.
A series of novel tetrahydropyrazolopyridone derivatives containing 1,3,4-triazole, triazolylmethyl, and partially saturated heterocyclic moieties as P2 binding element was designed, synthesized, and evaluated in vitro for anticoagulant activity in human and rabbit plasma. All compounds showed moderate to significant potency, and compounds 15b, 15c, 20b, 20c, and 22b were further examined for their inhibitory activity against human FXa in vitro. While compounds 15c and 22b were tested for rat venous thrombosis in vivo. The most promising compound 15c, with an IC Topics: Animals; Anticoagulants; Binding Sites; Blood Coagulation; Catalytic Domain; Drug Design; Factor Xa; Factor Xa Inhibitors; Humans; Molecular Docking Simulation; Protein Binding; Pyrazoles; Pyridines; Rabbits; Rats; Structure-Activity Relationship; Venous Thrombosis | 2017 |