pyrazolopyridine and Neuralgia

pyrazolopyridine has been researched along with Neuralgia* in 1 studies

Other Studies

1 other study(ies) available for pyrazolopyridine and Neuralgia

Article	Year
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain. Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15 Optimization of the novel alpha-2-delta-1 ligand 4 provided compounds 37 and 38 which have improved DMPK profiles, good in vivo analgesic activity and in vitro selectivity over alpha-2-delta-2. An in-house P-gp prediction programme and the MetaSite software package were used to help solve the specific problems of high P-gp efflux and high in vivo clearance. Topics: Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Ligands; Neuralgia; Pyrazoles; Pyridazines; Pyridines; Rats; Structure-Activity Relationship	2010

Article

Year

Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.

Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15

Optimization of the novel alpha-2-delta-1 ligand 4 provided compounds 37 and 38 which have improved DMPK profiles, good in vivo analgesic activity and in vitro selectivity over alpha-2-delta-2. An in-house P-gp prediction programme and the MetaSite software package were used to help solve the specific problems of high P-gp efflux and high in vivo clearance.

Topics: Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Ligands; Neuralgia; Pyrazoles; Pyridazines; Pyridines; Rats; Structure-Activity Relationship

2010