pyrazolopyridine has been researched along with Glioblastoma* in 1 studies
1 other study(ies) available for pyrazolopyridine and Glioblastoma
| Article | Year |
|---|---|
Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma.
Pyrazolopyrimidinones are fused nitrogen-containing heterocyclic systems, which act as a core scaffold in many pharmaceutically relevant compounds. Pyrazolopyrimidinones have been demonstrated to be efficient in treating several diseases, including cystic fibrosis, obesity, viral infection and cancer. In this study using glioblastoma U-251MG cell line, we tested the cytotoxic effects of 15 pyrazolopyrimidinones, synthesised via a two-step process, in combination with cold atmospheric plasma (CAP). CAP is an adjustable source of reactive oxygen and nitrogen species as well as other unique chemical and physical effects which has been successfully tested as an innovative cancer therapy in clinical trials. Significantly variable cytotoxicity was observed with IC Topics: Antineoplastic Agents; Cell Line, Tumor; Glioblastoma; Humans; Plasma Gases; Pyrazoles; Pyridines; Reactive Oxygen Species; Structure-Activity Relationship | 2021 |