pyrazolopyridine has been researched along with Diabetes-Mellitus--Type-2* in 1 studies
1 other study(ies) available for pyrazolopyridine and Diabetes-Mellitus--Type-2
| Article | Year |
|---|---|
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Glucokinase activators represent a promising potential treatment for patients with Type 2 diabetes. Herein, we report the identification and optimization of a series of novel indazole and pyrazolopyridine based activators leading to the identification of 4-(6-(azetidine-1-carbonyl)-5-fluoropyridin-3-yloxy)-2-ethyl-N-(5-methylpyrazin-2-yl)-2H-indazole-6-carboxamide (42) as a potent activator with favorable preclinical pharmacokinetic properties and in vivo efficacy. Topics: Administration, Oral; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Drug Design; Glucokinase; Glucose Tolerance Test; Half-Life; Humans; Hypoglycemic Agents; Indazoles; Insulin; Kinetics; Protein Binding; Pyrazines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2012 |