pyrazolo(1-5-a)pyrimidine and Hepatitis-C

pyrazolo(1-5-a)pyrimidine has been researched along with Hepatitis-C* in 1 studies

Other Studies

1 other study(ies) available for pyrazolo(1-5-a)pyrimidine and Hepatitis-C

Article	Year
Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase. Bioorganic & medicinal chemistry letters, 2009, Nov-15, Volume: 19, Issue:22 The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives. Topics: DNA-Directed RNA Polymerases; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hepacivirus; Hepatitis C; Inhibitory Concentration 50; Molecular Weight; Pyrazoles; Pyrimidines; RNA-Dependent RNA Polymerase; RNA, Viral; Small Molecule Libraries	2009

Article

Year

Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase.

Bioorganic & medicinal chemistry letters, 2009, Nov-15, Volume: 19, Issue:22

The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives.

Topics: DNA-Directed RNA Polymerases; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hepacivirus; Hepatitis C; Inhibitory Concentration 50; Molecular Weight; Pyrazoles; Pyrimidines; RNA-Dependent RNA Polymerase; RNA, Viral; Small Molecule Libraries

2009