pyrazolo(1-5-a)pyrimidine and Dry-Eye-Syndromes

pyrazolo(1-5-a)pyrimidine has been researched along with Dry-Eye-Syndromes* in 1 studies

Other Studies

1 other study(ies) available for pyrazolo(1-5-a)pyrimidine and Dry-Eye-Syndromes

Article	Year
Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5- Journal of medicinal chemistry, 2023, 01-12, Volume: 66, Issue:1 Dry eye disease (DED) is one of the most prevalent ocular diseases but has limited treatment options. Cystic fibrosis transmembrane conductance regulator (CFTR), a major chloride channel that stimulates fluid secretion in the ocular surface, may pave the way for new therapeutic strategies for DED. Herein, we report the optimization of Cact-3, a potent CFTR activator with poor solubility, to Topics: Animals; Conjunctiva; Cornea; Cystic Fibrosis Transmembrane Conductance Regulator; Dry Eye Syndromes; Mice; Pyrimidines; Rabbits; Solubility; Tears	2023

Article

Year

Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5-

Journal of medicinal chemistry, 2023, 01-12, Volume: 66, Issue:1

Dry eye disease (DED) is one of the most prevalent ocular diseases but has limited treatment options. Cystic fibrosis transmembrane conductance regulator (CFTR), a major chloride channel that stimulates fluid secretion in the ocular surface, may pave the way for new therapeutic strategies for DED. Herein, we report the optimization of Cact-3, a potent CFTR activator with poor solubility, to

Topics: Animals; Conjunctiva; Cornea; Cystic Fibrosis Transmembrane Conductance Regulator; Dry Eye Syndromes; Mice; Pyrimidines; Rabbits; Solubility; Tears

2023