pyrazole has been researched along with Weight Loss in 2 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Weight Loss: Decrease in existing BODY WEIGHT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Replacing the conventional pyrazole 5-aryl substituent of 1 (SR141716A) with the 2-thienyl moiety appended with an appropriate alkynyl unit, a novel class of 5-(5-alkynyl-2-thienyl)pyrazole derivatives, behaving as highly potent CB1 receptor antagonists with good CB1/2 selectivity, was discovered, many of which, as typified by compound 18, showed significant weight reduction in diet-induced obese mouse model, thus pharmacologically validating that the bioisosteric replacement described above is viable." | 3.74 | Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antag ( Chang, CP; Chao, YS; Chiu, HH; Chu, CM; Chung, WL; Hsieh, WP; Hung, MS; Kuo, CW; Lin, Y; Shia, KS; Song, JS; Tai, CL; Tseng, SL; Tung, YS; Wu, CH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Devasthale, P | 1 |
| Wang, W | 1 |
| Hernandez, AS | 1 |
| Moore, F | 1 |
| Renduchintala, K | 1 |
| Sridhar, R | 1 |
| Pelleymounter, MA | 1 |
| Longhi, D | 1 |
| Huang, N | 1 |
| Flynn, N | 1 |
| Azzara, AV | 1 |
| Rohrbach, K | 1 |
| Devenny, J | 1 |
| Rooney, S | 1 |
| Thomas, M | 1 |
| Glick, S | 1 |
| Godonis, H | 1 |
| Harvey, S | 1 |
| Cullen, MJ | 1 |
| Zhang, H | 1 |
| Caporuscio, C | 1 |
| Stetsko, P | 1 |
| Grubb, M | 1 |
| Huang, C | 1 |
| Zhang, L | 1 |
| Freeden, C | 1 |
| Li, YX | 1 |
| Murphy, BJ | 1 |
| Robl, JA | 1 |
| Washburn, WN | 1 |
| Tseng, SL | 1 |
| Hung, MS | 1 |
| Chang, CP | 1 |
| Song, JS | 1 |
| Tai, CL | 1 |
| Chiu, HH | 1 |
| Hsieh, WP | 1 |
| Lin, Y | 1 |
| Chung, WL | 1 |
| Kuo, CW | 1 |
| Wu, CH | 1 |
| Chu, CM | 1 |
| Tung, YS | 1 |
| Chao, YS | 1 |
| Shia, KS | 1 |
2 other studies available for pyrazole and Weight Loss
| Article | Year |
|---|---|
Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup.
Topics: Animals; Anti-Obesity Agents; Half-Life; Humans; Obesity; Protein Binding; Pyrazoles; Rats; Rats, Sp | 2015 |
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antag
Topics: Animals; Binding Sites; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Obese; Piperidines; Py | 2008 |