pyrazole has been researched along with Neoplasms in 15 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 1956, the anti-cancer activity of pyrazolopyrimidine was evaluated for the first time with appreciable results." | 2.66 | An assessment study of known pyrazolopyrimidines: Chemical methodology and cellular activity. ( Chanda, K; Rao, RN, 2020) |
| "Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry." | 2.58 | The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review. ( Dwivedi, J; Jain, S; Sharma, S; Singh, A, 2018) |
| "Pyrazole has been the topic of interest for thousands of researchers across the world because of its wide spectrum pharmacological activities." | 2.49 | Pyrazole scaffold: a remarkable tool in the development of anticancer agents. ( Jain, N; Jain, S; Kumar, H; Saini, D, 2013) |
| "The in vitro anticancer evaluation revealed that compounds 2a and 4-6(a) exhibited increased potency towards CNS SNB-75 and Renal UO-31 cancer cell lines." | 1.40 | Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties. ( Ali, AR; El-Bendary, ER; Ghaly, MA; Shehata, IA, 2014) |
| "To examine the anticancer activity several novel thiazolone-based compounds containing 5-aryl-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl framework were obtained." | 1.35 | Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity. ( Gzella, A; Havrylyuk, D; Lesyk, R; Vasylenko, O; Zaprutko, L; Zimenkovsky, B, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 11 (73.33) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Muravev, AA | 1 |
| Voloshina, AD | 1 |
| Sapunova, AS | 1 |
| Gabdrakhmanova, FB | 1 |
| Lenina, OA | 1 |
| Petrov, KA | 1 |
| Shityakov, S | 1 |
| Skorb, EV | 1 |
| Solovieva, SE | 1 |
| Antipin, IS | 1 |
| Rao, RN | 1 |
| Chanda, K | 1 |
| Dwivedi, J | 1 |
| Sharma, S | 1 |
| Jain, S | 2 |
| Singh, A | 1 |
| Wang, PF | 1 |
| Wang, ZF | 1 |
| Qiu, HY | 1 |
| Huang, Y | 1 |
| Hu, HM | 1 |
| Wang, ZC | 1 |
| Zhu, HL | 2 |
| Koca, İ | 1 |
| Özgür, A | 1 |
| Coşkun, KA | 1 |
| Tutar, Y | 1 |
| Kumar, H | 1 |
| Saini, D | 1 |
| Jain, N | 1 |
| Ali, AR | 1 |
| El-Bendary, ER | 1 |
| Ghaly, MA | 1 |
| Shehata, IA | 1 |
| Cankara Pirol, Ş | 1 |
| Çalışkan, B | 1 |
| Durmaz, I | 1 |
| Atalay, R | 1 |
| Banoglu, E | 1 |
| Zhuang, C | 1 |
| Sheng, C | 1 |
| Shin, WS | 1 |
| Wu, Y | 1 |
| Li, J | 1 |
| Yao, J | 1 |
| Dong, G | 1 |
| Zhang, W | 2 |
| Sham, YY | 1 |
| Miao, Z | 1 |
| Havrylyuk, D | 1 |
| Zimenkovsky, B | 1 |
| Vasylenko, O | 1 |
| Zaprutko, L | 1 |
| Gzella, A | 1 |
| Lesyk, R | 1 |
| Mahindroo, N | 1 |
| Connelly, MC | 1 |
| Punchihewa, C | 1 |
| Kimura, H | 1 |
| Smeltzer, MP | 1 |
| Wu, S | 1 |
| Fujii, N | 1 |
| Insuasty, B | 1 |
| Tigreros, A | 1 |
| Orozco, F | 1 |
| Quiroga, J | 1 |
| Abonía, R | 1 |
| Nogueras, M | 1 |
| Sanchez, A | 1 |
| Cobo, J | 1 |
| Lv, PC | 1 |
| Li, HQ | 1 |
| Sun, J | 1 |
| Zhou, Y | 1 |
| Bandgar, BP | 1 |
| Totre, JV | 1 |
| Gawande, SS | 1 |
| Khobragade, CN | 1 |
| Warangkar, SC | 1 |
| Kadam, PD | 1 |
| Sobiesiak, M | 1 |
| Lorenz, IP | 1 |
| Mayer, P | 1 |
| Woźniczka, M | 1 |
| Kufelnicki, A | 1 |
| Krajewska, U | 1 |
| Rozalski, M | 1 |
| Budzisz, E | 1 |
3 reviews available for pyrazole and Neoplasms
| Article | Year |
|---|---|
An assessment study of known pyrazolopyrimidines: Chemical methodology and cellular activity.
Topics: Antineoplastic Agents; Cell Proliferation; Humans; Molecular Structure; Neoplasms; Phosphotransferas | 2020 |
The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Antineoplastic Agents; Antiox | 2018 |
Pyrazole scaffold: a remarkable tool in the development of anticancer agents.
Topics: Animals; Antineoplastic Agents; Humans; Models, Molecular; Neoplasms; Pyrazoles | 2013 |
12 other studies available for pyrazole and Neoplasms
| Article | Year |
|---|---|
Calix[4]arene-pyrazole conjugates as potential cancer therapeutics.
Topics: Animals; Calixarenes; HeLa Cells; Humans; Mice; Neoplasms; Porifera; Pyrazoles | 2023 |
Identification and Biological Evaluation of Novel Type II B-Raf
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Drug Design; Female; Humans | 2018 |
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Neoplasms; Pyrazoles; Structure | 2013 |
Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties.
Topics: Antineoplastic Agents; Cell Line, Tumor; Computer Simulation; Drug Design; Drug Screening Assays, An | 2014 |
Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carboxylic Acids; Cell Cycle Checkpoints; Cell | 2014 |
A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Drug Discovery; Dr | 2014 |
Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Human | 2009 |
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Genes, Rep | 2009 |
Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chalcones; Drug Screening A | 2010 |
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Computer Simulation; ErbB Receptors; Humans; | 2010 |
Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents.
Topics: Agaricales; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Scree | 2010 |
Synthesis, X-ray structure and cytotoxic effect of nickel(II) complexes with pyrazole ligands.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chelating Agents; Coordination Complexes; Cr | 2011 |