Page last updated: 2024-10-20

pyrazole and Neoplasms

pyrazole has been researched along with Neoplasms in 15 studies

1H-pyrazole : The 1H-tautomer of pyrazole.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"In 1956, the anti-cancer activity of pyrazolopyrimidine was evaluated for the first time with appreciable results."2.66An assessment study of known pyrazolopyrimidines: Chemical methodology and cellular activity. ( Chanda, K; Rao, RN, 2020)
"Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry."2.58The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review. ( Dwivedi, J; Jain, S; Sharma, S; Singh, A, 2018)
"Pyrazole has been the topic of interest for thousands of researchers across the world because of its wide spectrum pharmacological activities."2.49Pyrazole scaffold: a remarkable tool in the development of anticancer agents. ( Jain, N; Jain, S; Kumar, H; Saini, D, 2013)
"The in vitro anticancer evaluation revealed that compounds 2a and 4-6(a) exhibited increased potency towards CNS SNB-75 and Renal UO-31 cancer cell lines."1.40Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties. ( Ali, AR; El-Bendary, ER; Ghaly, MA; Shehata, IA, 2014)
"To examine the anticancer activity several novel thiazolone-based compounds containing 5-aryl-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl framework were obtained."1.35Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity. ( Gzella, A; Havrylyuk, D; Lesyk, R; Vasylenko, O; Zaprutko, L; Zimenkovsky, B, 2009)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (13.33)29.6817
2010's11 (73.33)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Muravev, AA1
Voloshina, AD1
Sapunova, AS1
Gabdrakhmanova, FB1
Lenina, OA1
Petrov, KA1
Shityakov, S1
Skorb, EV1
Solovieva, SE1
Antipin, IS1
Rao, RN1
Chanda, K1
Dwivedi, J1
Sharma, S1
Jain, S2
Singh, A1
Wang, PF1
Wang, ZF1
Qiu, HY1
Huang, Y1
Hu, HM1
Wang, ZC1
Zhu, HL2
Koca, İ1
Özgür, A1
Coşkun, KA1
Tutar, Y1
Kumar, H1
Saini, D1
Jain, N1
Ali, AR1
El-Bendary, ER1
Ghaly, MA1
Shehata, IA1
Cankara Pirol, Ş1
Çalışkan, B1
Durmaz, I1
Atalay, R1
Banoglu, E1
Zhuang, C1
Sheng, C1
Shin, WS1
Wu, Y1
Li, J1
Yao, J1
Dong, G1
Zhang, W2
Sham, YY1
Miao, Z1
Havrylyuk, D1
Zimenkovsky, B1
Vasylenko, O1
Zaprutko, L1
Gzella, A1
Lesyk, R1
Mahindroo, N1
Connelly, MC1
Punchihewa, C1
Kimura, H1
Smeltzer, MP1
Wu, S1
Fujii, N1
Insuasty, B1
Tigreros, A1
Orozco, F1
Quiroga, J1
Abonía, R1
Nogueras, M1
Sanchez, A1
Cobo, J1
Lv, PC1
Li, HQ1
Sun, J1
Zhou, Y1
Bandgar, BP1
Totre, JV1
Gawande, SS1
Khobragade, CN1
Warangkar, SC1
Kadam, PD1
Sobiesiak, M1
Lorenz, IP1
Mayer, P1
Woźniczka, M1
Kufelnicki, A1
Krajewska, U1
Rozalski, M1
Budzisz, E1

Reviews

3 reviews available for pyrazole and Neoplasms

ArticleYear
An assessment study of known pyrazolopyrimidines: Chemical methodology and cellular activity.
    Bioorganic chemistry, 2020, Volume: 99

    Topics: Antineoplastic Agents; Cell Proliferation; Humans; Molecular Structure; Neoplasms; Phosphotransferas

2020
The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review.
    Mini reviews in medicinal chemistry, 2018, Volume: 18, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Antineoplastic Agents; Antiox

2018
Pyrazole scaffold: a remarkable tool in the development of anticancer agents.
    European journal of medicinal chemistry, 2013, Volume: 70

    Topics: Animals; Antineoplastic Agents; Humans; Models, Molecular; Neoplasms; Pyrazoles

2013

Other Studies

12 other studies available for pyrazole and Neoplasms

ArticleYear
Calix[4]arene-pyrazole conjugates as potential cancer therapeutics.
    Bioorganic chemistry, 2023, Volume: 139

    Topics: Animals; Calixarenes; HeLa Cells; Humans; Mice; Neoplasms; Porifera; Pyrazoles

2023
Identification and Biological Evaluation of Novel Type II B-Raf
    ChemMedChem, 2018, 12-06, Volume: 13, Issue:23

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Drug Design; Female; Humans

2018
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety.
    Bioorganic & medicinal chemistry, 2013, Jul-01, Volume: 21, Issue:13

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Neoplasms; Pyrazoles; Structure

2013
Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties.
    European journal of medicinal chemistry, 2014, Mar-21, Volume: 75

    Topics: Antineoplastic Agents; Cell Line, Tumor; Computer Simulation; Drug Design; Drug Screening Assays, An

2014
Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carboxylic Acids; Cell Cycle Checkpoints; Cell

2014
A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways.
    Oncotarget, 2014, Nov-15, Volume: 5, Issue:21

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Drug Discovery; Dr

2014
Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Human

2009
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.
    Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Genes, Rep

2009
Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents.
    Bioorganic & medicinal chemistry, 2010, Jul-15, Volume: 18, Issue:14

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chalcones; Drug Screening A

2010
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents.
    Bioorganic & medicinal chemistry, 2010, Jul-01, Volume: 18, Issue:13

    Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Computer Simulation; ErbB Receptors; Humans;

2010
Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16

    Topics: Agaricales; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Scree

2010
Synthesis, X-ray structure and cytotoxic effect of nickel(II) complexes with pyrazole ligands.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chelating Agents; Coordination Complexes; Cr

2011