pyrazole has been researched along with Malaria in 3 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compounds were evaluated for their in vivo antimalarial activity against Plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (RKL9) strain of Plasmodium falciparum." | 7.81 | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. ( Abd El Razik, HA; Bekhit, AA; Bekhit, Ael-D; El-Agroudy, EJ; El-Miligy, MM; Hassan, AM, 2015) |
| "The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of 1,1,1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been evaluated in vitro against a chloroquine resistant Plasmodium falciparum clone." | 7.73 | Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues. ( Bonacorso, HG; Cechinel, CA; Cunico, W; de Souza, MV; Freitas, IO; Krettli, AU; Martins, MA; Soares, RP; Zanatta, N, 2006) |
| " The compounds were evaluated for their in vivo antimalarial activity against Plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (RKL9) strain of Plasmodium falciparum." | 3.81 | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. ( Abd El Razik, HA; Bekhit, AA; Bekhit, Ael-D; El-Agroudy, EJ; El-Miligy, MM; Hassan, AM, 2015) |
| "The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of 1,1,1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been evaluated in vitro against a chloroquine resistant Plasmodium falciparum clone." | 3.73 | Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues. ( Bonacorso, HG; Cechinel, CA; Cunico, W; de Souza, MV; Freitas, IO; Krettli, AU; Martins, MA; Soares, RP; Zanatta, N, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vaidya, AB | 1 |
| Morrisey, JM | 1 |
| Zhang, Z | 1 |
| Das, S | 1 |
| Daly, TM | 1 |
| Otto, TD | 1 |
| Spillman, NJ | 1 |
| Wyvratt, M | 1 |
| Siegl, P | 1 |
| Marfurt, J | 1 |
| Wirjanata, G | 1 |
| Sebayang, BF | 1 |
| Price, RN | 1 |
| Chatterjee, A | 1 |
| Nagle, A | 1 |
| Stasiak, M | 1 |
| Charman, SA | 1 |
| Angulo-Barturen, I | 1 |
| Ferrer, S | 1 |
| Belén Jiménez-Díaz, M | 1 |
| Martínez, MS | 1 |
| Gamo, FJ | 1 |
| Avery, VM | 1 |
| Ruecker, A | 1 |
| Delves, M | 1 |
| Kirk, K | 1 |
| Berriman, M | 1 |
| Kortagere, S | 1 |
| Burrows, J | 1 |
| Fan, E | 1 |
| Bergman, LW | 1 |
| Bekhit, AA | 1 |
| Hassan, AM | 1 |
| Abd El Razik, HA | 1 |
| El-Miligy, MM | 1 |
| El-Agroudy, EJ | 1 |
| Bekhit, Ael-D | 1 |
| Cunico, W | 1 |
| Cechinel, CA | 1 |
| Bonacorso, HG | 1 |
| Martins, MA | 1 |
| Zanatta, N | 1 |
| de Souza, MV | 1 |
| Freitas, IO | 1 |
| Soares, RP | 1 |
| Krettli, AU | 1 |
3 other studies available for pyrazole and Malaria
| Article | Year |
|---|---|
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.
Topics: Adenosine Triphosphatases; Amides; Antimalarials; Benzimidazoles; Erythrocytes; Female; Homeostasis; | 2014 |
New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents.
Topics: Animals; Antimalarials; Chemistry Techniques, Synthetic; Chloroquine; Drug Design; Drug Evaluation, | 2015 |
Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Parasitic Se | 2006 |