pyrazole has been researched along with Leishmaniasis in 6 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Leishmaniasis: A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compounds were evaluated for their in vivo antimalarial activity against Plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (RKL9) strain of Plasmodium falciparum." | 7.81 | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. ( Abd El Razik, HA; Bekhit, AA; Bekhit, Ael-D; El-Agroudy, EJ; El-Miligy, MM; Hassan, AM, 2015) |
| " The compounds were evaluated for their in vivo antimalarial activity against Plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (RKL9) strain of Plasmodium falciparum." | 3.81 | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. ( Abd El Razik, HA; Bekhit, AA; Bekhit, Ael-D; El-Agroudy, EJ; El-Miligy, MM; Hassan, AM, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goyal, S | 1 |
| Dhanjal, JK | 1 |
| Tyagi, C | 1 |
| Goyal, M | 1 |
| Grover, A | 1 |
| Navarro, P | 1 |
| Sánchez-Moreno, M | 1 |
| Marín, C | 1 |
| García-España, E | 1 |
| Ramírez-Macías, I | 1 |
| Olmo, F | 1 |
| Rosales, MJ | 1 |
| Gómez-Contreras, F | 1 |
| Yunta, MJ | 1 |
| Gutierrez-Sánchez, R | 1 |
| Bekhit, AA | 1 |
| Hassan, AM | 1 |
| Abd El Razik, HA | 1 |
| El-Miligy, MM | 1 |
| El-Agroudy, EJ | 1 |
| Bekhit, Ael-D | 1 |
| Cleghorn, LA | 1 |
| Woodland, A | 1 |
| Collie, IT | 1 |
| Torrie, LS | 1 |
| Norcross, N | 1 |
| Luksch, T | 1 |
| Mpamhanga, C | 1 |
| Walker, RG | 1 |
| Mottram, JC | 1 |
| Brenk, R | 1 |
| Frearson, JA | 1 |
| Gilbert, IH | 1 |
| Wyatt, PG | 1 |
| dos Santos, MS | 1 |
| Oliveira, ML | 1 |
| Bernardino, AM | 2 |
| de Léo, RM | 1 |
| Amaral, VF | 2 |
| de Carvalho, FT | 1 |
| Leon, LL | 2 |
| Canto-Cavalheiro, MM | 2 |
| Gomes, AO | 1 |
| Charret, KS | 1 |
| Freitas, AC | 1 |
| Machado, GM | 1 |
6 other studies available for pyrazole and Leishmaniasis
| Article | Year |
|---|---|
Novel fragment-based QSAR modeling and combinatorial design of pyrazole-derived CRK3 inhibitors as potent antileishmanials.
Topics: Antiprotozoal Agents; Cyclin-Dependent Kinases; Drug Design; Humans; Leishmania; Leishmaniasis; Mode | 2014 |
In vitro leishmanicidal activity of pyrazole-containing polyamine macrocycles which inhibit the Fe-SOD enzyme of Leishmania infantum and Leishmania braziliensis species.
Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Erythrocytes; Female; Humans; Leishmania br | 2014 |
New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents.
Topics: Animals; Antimalarials; Chemistry Techniques, Synthetic; Chloroquine; Drug Design; Drug Evaluation, | 2015 |
Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.
Topics: Binding Sites; CDC2 Protein Kinase; Computer Simulation; Drug Evaluation, Preclinical; Humans; Leish | 2011 |
Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives.
Topics: Animals; Antiprotozoal Agents; Imidazoles; Leishmania; Leishmaniasis; Mice; Pyrazoles; Structure-Act | 2011 |
Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N'-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides.
Topics: Animals; Antiprotozoal Agents; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Hydrazi | 2006 |