Page last updated: 2024-10-20

pyrazole and Edema

pyrazole has been researched along with Edema in 20 studies

1H-pyrazole : The 1H-tautomer of pyrazole.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo."3.77Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives. ( Bantu, R; Gaikwad, HK; Mateti, J; Nagarapu, L; Prameela Subhashini, NJ; Sheeba Rani, M, 2011)
" The prepared compounds were evaluated for their anti-inflammatory activity using carrageenan-induced rat paw edema and compared to a well-known NSAID, indomethacin as a reference drug."3.75Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives. ( Abdel-Aziz, M; Aly, OM; Farag, HH; Morsy, MA; Shoman, ME, 2009)
" Among the 12 prepared compounds, Compounds 3d, e, i and j exhibited significant anti-inflammatory activity in model of acute inflammation such as carrageenan-induced rat edema paw while compounds 3d and e showed considerable activity in model of chronic inflammation such as adjuvant-induced arthritis and were compared with diclofenac (13."3.75Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. ( Aragade, P; Khode, S; Maddi, V; Mamledesai, S; Palkar, M; Ronad, PK; Satyanarayana, D; Thippeswamy, AH, 2009)
" All the target compounds showed anti-inflammatory activity and three of them 3b, 3c and 4c surpassed that of indomethacin both locally and systemically in the cotton pellet granuloma and rat paw edema bioassay."3.74Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. ( Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D, 2008)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's0 (0.00)18.2507
2000's5 (25.00)29.6817
2010's11 (55.00)24.3611
2020's3 (15.00)2.80

Authors

AuthorsStudies
Mironov, ME1
Borisov, SA1
Rybalova, TV1
Baev, DS1
Tolstikova, TG1
Shults, EE1
Gulnaz, AR1
Mohammed, YHE1
Khanum, SA1
Abdellatif, KR1
El-Saadi, MT1
Elzayat, SG1
Amin, NH1
Marzouk, AA1
Taher, ES1
Shaykoon, MSA1
Lan, P1
Abd-Allah, WH1
Aboregela, AM1
El-Behairy, MF1
Abdellatif, KRA1
Abdelall, EKA1
Elshemy, HAH1
Philoppes, JN1
Hassanein, EHM1
Kahk, NM1
Nossier, ES1
Fahmy, HH1
Khalifa, NM1
El-Eraky, WI1
Baset, MA1
Batista, DC1
Silva, DPB1
Florentino, IF1
Cardoso, CS1
Gonçalves, MP1
Valadares, MC1
Lião, LM1
Sanz, G1
Vaz, BG1
Costa, EA1
Menegatti, R1
Taher, AT1
Mostafa Sarg, MT1
El-Sayed Ali, NR1
Hilmy Elnagdi, N1
Jadhav, SY1
Shirame, SP1
Kulkarni, SD1
Patil, SB1
Pasale, SK1
Bhosale, RB1
Mohammed, KO1
Nissan, YM1
Viveka, S1
Shama, P1
Nagaraja, GK1
Ballav, S1
Kerkar, S1
Shoman, ME1
Abdel-Aziz, M1
Aly, OM1
Farag, HH1
Morsy, MA1
Khode, S1
Maddi, V1
Aragade, P1
Palkar, M1
Ronad, PK1
Mamledesai, S1
Thippeswamy, AH1
Satyanarayana, D1
Mohy El-Din, MM1
Senbel, AM1
Bistawroos, AA1
El-Mallah, A1
Nour El-Din, NA1
Bekhit, AA2
Abd El Razik, HA1
El-Sayed, MA1
Abdel-Aziz, NI1
Abdel-Aziz, AA1
El-Azab, AS1
Asiri, YA1
Eltahir, KE1
Nagarapu, L1
Mateti, J1
Gaikwad, HK1
Bantu, R1
Sheeba Rani, M1
Prameela Subhashini, NJ1
WILHELMI, G1
DOMENJOZ, R1
Dinges, J1
Akritopoulou-Zanze, I1
Arnold, LD1
Barlozzari, T1
Bousquet, PF1
Cunha, GA1
Ericsson, AM1
Iwasaki, N1
Michaelides, MR1
Ogawa, N1
Phelan, KM1
Rafferty, P1
Sowin, TJ1
Stewart, KD1
Tokuyama, R1
Xia, Z1
Zhang, HQ1
Ashour, HM1
Abdel Ghany, YS1
Bekhit, Ael-D1
Baraka, A1
Gökhan-Kelekçi, N1
Yabanoğlu, S1
Küpeli, E1
Salgin, U1
Ozgen, O1
Uçar, G1
Yeşilada, E1
Kendi, E1
Yeşilada, A1
Bilgin, AA1

Other Studies

20 other studies available for pyrazole and Edema

ArticleYear
Synthesis of Anti-Inflammatory Spirostene-Pyrazole Conjugates by a Consecutive Multicomponent Reaction of Diosgenin with Oxalyl Chloride, Arylalkynes and Hydrazines or Hydrazones.
    Molecules (Basel, Switzerland), 2021, Dec-28, Volume: 27, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Chlorides; Combinatorial Chemist

2021
Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents.
    Bioorganic chemistry, 2019, Volume: 92

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Cyclooxyge

2019
New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents.
    Future medicinal chemistry, 2019, Volume: 11, Issue:15

    Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Catalytic Domain; Celecoxib; Cyclooxygenase 1; Cyc

2019
Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment.
    Bioorganic chemistry, 2021, Volume: 111

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Apoptosis; Cyclooxygenase 2 Inhibitors; Dose-R

2021
Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and mol
    Bioorganic chemistry, 2021, Volume: 114

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiotonic Agents; Carrageenan; Cyclooxygenase 2;

2021
Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents.
    Molecules (Basel, Switzerland), 2017, Mar-24, Volume: 22, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Drug Design; E

2017
Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone.
    Inflammopharmacology, 2018, Volume: 26, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; BALB 3T3 Cells; Carrageenan; Cell Line; Cell Movement

2018
Design, synthesis, modeling studies and biological screening of novel pyrazole derivatives as potential analgesic and anti-inflammatory agents.
    Bioorganic chemistry, 2019, Volume: 89

    Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Car

2019
PEG mediated synthesis and pharmacological evaluation of some fluoro substituted pyrazoline derivatives as antiinflammatory and analgesic agents.
    Bioorganic & medicinal chemistry letters, 2013, May-01, Volume: 23, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Fluorine; Polyethylene Glycols; Pyrazoles; Rat

2013
Synthesis, molecular docking, and biological evaluation of some novel hydrazones and pyrazole derivatives as anti-inflammatory agents.
    Chemical biology & drug design, 2014, Volume: 84, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Carrageenan; Catalytic Domain; Cyclooxygenase 1; C

2014
Design and synthesis of some new pyrazolyl-pyrazolines as potential anti-inflammatory, analgesic and antibacterial agents.
    European journal of medicinal chemistry, 2015, Aug-28, Volume: 101

    Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Carra

2015
Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Edema; Indomethacin; Male; Nitric Oxide; Pyrazoles; Rats; Referen

2009
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Female; Male; Mic

2009
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 108, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic

2011
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
    Bioorganic & medicinal chemistry, 2011, Jun-01, Volume: 19, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Computer Simulation; Cyclooxygenase 1; Cyclooxygen

2011
Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives.
    Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14

    Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Pyrazoles; Rats

2011
[Effect of pyrazoles, cortisone and ACTH in experimental egg-white edema in the rat; plethysmographic registration of the degree of swelling].
    Arzneimittel-Forschung, 1951, Volume: 1, Issue:4

    Topics: Adrenocorticotropic Hormone; Animals; Cortisone; Edema; Pyrazoles; Rats

1951
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.
    Bioorganic & medicinal chemistry letters, 2006, Aug-15, Volume: 16, Issue:16

    Topics: Administration, Oral; Animals; Chemistry, Pharmaceutical; Drug Design; Edema; Estradiol; Female; Ind

2006
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; C

2008
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.
    Bioorganic & medicinal chemistry, 2007, Sep-01, Volume: 15, Issue:17

    Topics: Alzheimer Disease; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Hydrogen Bonding;

2007