pyrazole has been researched along with Edema in 20 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Excerpt | Relevance | Reference |
---|---|---|
"A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo." | 3.77 | Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives. ( Bantu, R; Gaikwad, HK; Mateti, J; Nagarapu, L; Prameela Subhashini, NJ; Sheeba Rani, M, 2011) |
" The prepared compounds were evaluated for their anti-inflammatory activity using carrageenan-induced rat paw edema and compared to a well-known NSAID, indomethacin as a reference drug." | 3.75 | Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives. ( Abdel-Aziz, M; Aly, OM; Farag, HH; Morsy, MA; Shoman, ME, 2009) |
" Among the 12 prepared compounds, Compounds 3d, e, i and j exhibited significant anti-inflammatory activity in model of acute inflammation such as carrageenan-induced rat edema paw while compounds 3d and e showed considerable activity in model of chronic inflammation such as adjuvant-induced arthritis and were compared with diclofenac (13." | 3.75 | Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. ( Aragade, P; Khode, S; Maddi, V; Mamledesai, S; Palkar, M; Ronad, PK; Satyanarayana, D; Thippeswamy, AH, 2009) |
" All the target compounds showed anti-inflammatory activity and three of them 3b, 3c and 4c surpassed that of indomethacin both locally and systemically in the cotton pellet granuloma and rat paw edema bioassay." | 3.74 | Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. ( Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D, 2008) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (5.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (25.00) | 29.6817 |
2010's | 11 (55.00) | 24.3611 |
2020's | 3 (15.00) | 2.80 |
Authors | Studies |
---|---|
Mironov, ME | 1 |
Borisov, SA | 1 |
Rybalova, TV | 1 |
Baev, DS | 1 |
Tolstikova, TG | 1 |
Shults, EE | 1 |
Gulnaz, AR | 1 |
Mohammed, YHE | 1 |
Khanum, SA | 1 |
Abdellatif, KR | 1 |
El-Saadi, MT | 1 |
Elzayat, SG | 1 |
Amin, NH | 1 |
Marzouk, AA | 1 |
Taher, ES | 1 |
Shaykoon, MSA | 1 |
Lan, P | 1 |
Abd-Allah, WH | 1 |
Aboregela, AM | 1 |
El-Behairy, MF | 1 |
Abdellatif, KRA | 1 |
Abdelall, EKA | 1 |
Elshemy, HAH | 1 |
Philoppes, JN | 1 |
Hassanein, EHM | 1 |
Kahk, NM | 1 |
Nossier, ES | 1 |
Fahmy, HH | 1 |
Khalifa, NM | 1 |
El-Eraky, WI | 1 |
Baset, MA | 1 |
Batista, DC | 1 |
Silva, DPB | 1 |
Florentino, IF | 1 |
Cardoso, CS | 1 |
Gonçalves, MP | 1 |
Valadares, MC | 1 |
Lião, LM | 1 |
Sanz, G | 1 |
Vaz, BG | 1 |
Costa, EA | 1 |
Menegatti, R | 1 |
Taher, AT | 1 |
Mostafa Sarg, MT | 1 |
El-Sayed Ali, NR | 1 |
Hilmy Elnagdi, N | 1 |
Jadhav, SY | 1 |
Shirame, SP | 1 |
Kulkarni, SD | 1 |
Patil, SB | 1 |
Pasale, SK | 1 |
Bhosale, RB | 1 |
Mohammed, KO | 1 |
Nissan, YM | 1 |
Viveka, S | 1 |
Shama, P | 1 |
Nagaraja, GK | 1 |
Ballav, S | 1 |
Kerkar, S | 1 |
Shoman, ME | 1 |
Abdel-Aziz, M | 1 |
Aly, OM | 1 |
Farag, HH | 1 |
Morsy, MA | 1 |
Khode, S | 1 |
Maddi, V | 1 |
Aragade, P | 1 |
Palkar, M | 1 |
Ronad, PK | 1 |
Mamledesai, S | 1 |
Thippeswamy, AH | 1 |
Satyanarayana, D | 1 |
Mohy El-Din, MM | 1 |
Senbel, AM | 1 |
Bistawroos, AA | 1 |
El-Mallah, A | 1 |
Nour El-Din, NA | 1 |
Bekhit, AA | 2 |
Abd El Razik, HA | 1 |
El-Sayed, MA | 1 |
Abdel-Aziz, NI | 1 |
Abdel-Aziz, AA | 1 |
El-Azab, AS | 1 |
Asiri, YA | 1 |
Eltahir, KE | 1 |
Nagarapu, L | 1 |
Mateti, J | 1 |
Gaikwad, HK | 1 |
Bantu, R | 1 |
Sheeba Rani, M | 1 |
Prameela Subhashini, NJ | 1 |
WILHELMI, G | 1 |
DOMENJOZ, R | 1 |
Dinges, J | 1 |
Akritopoulou-Zanze, I | 1 |
Arnold, LD | 1 |
Barlozzari, T | 1 |
Bousquet, PF | 1 |
Cunha, GA | 1 |
Ericsson, AM | 1 |
Iwasaki, N | 1 |
Michaelides, MR | 1 |
Ogawa, N | 1 |
Phelan, KM | 1 |
Rafferty, P | 1 |
Sowin, TJ | 1 |
Stewart, KD | 1 |
Tokuyama, R | 1 |
Xia, Z | 1 |
Zhang, HQ | 1 |
Ashour, HM | 1 |
Abdel Ghany, YS | 1 |
Bekhit, Ael-D | 1 |
Baraka, A | 1 |
Gökhan-Kelekçi, N | 1 |
Yabanoğlu, S | 1 |
Küpeli, E | 1 |
Salgin, U | 1 |
Ozgen, O | 1 |
Uçar, G | 1 |
Yeşilada, E | 1 |
Kendi, E | 1 |
Yeşilada, A | 1 |
Bilgin, AA | 1 |
20 other studies available for pyrazole and Edema
Article | Year |
---|---|
Synthesis of Anti-Inflammatory Spirostene-Pyrazole Conjugates by a Consecutive Multicomponent Reaction of Diosgenin with Oxalyl Chloride, Arylalkynes and Hydrazines or Hydrazones.
Topics: Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Chlorides; Combinatorial Chemist | 2021 |
Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Cyclooxyge | 2019 |
New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Catalytic Domain; Celecoxib; Cyclooxygenase 1; Cyc | 2019 |
Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Apoptosis; Cyclooxygenase 2 Inhibitors; Dose-R | 2021 |
Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and mol
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiotonic Agents; Carrageenan; Cyclooxygenase 2; | 2021 |
Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Drug Design; E | 2017 |
Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BALB 3T3 Cells; Carrageenan; Cell Line; Cell Movement | 2018 |
Design, synthesis, modeling studies and biological screening of novel pyrazole derivatives as potential analgesic and anti-inflammatory agents.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Car | 2019 |
PEG mediated synthesis and pharmacological evaluation of some fluoro substituted pyrazoline derivatives as antiinflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Fluorine; Polyethylene Glycols; Pyrazoles; Rat | 2013 |
Synthesis, molecular docking, and biological evaluation of some novel hydrazones and pyrazole derivatives as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Carrageenan; Catalytic Domain; Cyclooxygenase 1; C | 2014 |
Design and synthesis of some new pyrazolyl-pyrazolines as potential anti-inflammatory, analgesic and antibacterial agents.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Carra | 2015 |
Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.
Topics: Animals; Anti-Inflammatory Agents; Edema; Indomethacin; Male; Nitric Oxide; Pyrazoles; Rats; Referen | 2009 |
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Female; Male; Mic | 2009 |
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic | 2011 |
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Computer Simulation; Cyclooxygenase 1; Cyclooxygen | 2011 |
Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Pyrazoles; Rats | 2011 |
[Effect of pyrazoles, cortisone and ACTH in experimental egg-white edema in the rat; plethysmographic registration of the degree of swelling].
Topics: Adrenocorticotropic Hormone; Animals; Cortisone; Edema; Pyrazoles; Rats | 1951 |
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.
Topics: Administration, Oral; Animals; Chemistry, Pharmaceutical; Drug Design; Edema; Estradiol; Female; Ind | 2006 |
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; C | 2008 |
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.
Topics: Alzheimer Disease; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Hydrogen Bonding; | 2007 |