pyrazole has been researched along with Chemical and Drug Induced Liver Injury in 17 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrazole treatment to induce cytochrome P-450 2E1 (CYP2E1) was recently shown to cause liver injury in ob/ob mice but not in lean mice." | 1.34 | S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury. ( Caro, AA; Cederbaum, AI; Dey, A, 2007) |
| "Obesity is a growing health problem in the United States." | 1.34 | Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. ( Cederbaum, AI; Dey, A, 2007) |
| "S-Adenosyl-l-methionine (SAM) has been shown to be hepatoprotective against many toxic agents." | 1.33 | S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice. ( Cederbaum, AI; Wang, X, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, MK | 1 |
| Han, JM | 1 |
| Kim, HG | 1 |
| Lee, JS | 2 |
| Wang, JH | 1 |
| Son, SW | 1 |
| Park, HJ | 1 |
| Son, CG | 1 |
| Lu, Y | 4 |
| Gong, P | 1 |
| Cederbaum, AI | 8 |
| Zhuge, J | 1 |
| Wu, D | 3 |
| Cederbaum, A | 2 |
| Wang, X | 3 |
| Yang, L | 1 |
| Leung, TM | 1 |
| Ward, SC | 1 |
| Nieto, N | 1 |
| Bae, SH | 1 |
| Sung, SH | 1 |
| Lee, HE | 1 |
| Kang, HT | 1 |
| Lee, SK | 1 |
| Oh, SY | 1 |
| Woo, HA | 1 |
| Kil, IS | 1 |
| Rhee, SG | 1 |
| Gilmore, WJ | 1 |
| Kirby, GM | 1 |
| Anke, J | 1 |
| Fu, S | 1 |
| Ramzan, I | 1 |
| Dey, A | 2 |
| Caro, AA | 1 |
| Lauriault, VV | 1 |
| Khan, S | 1 |
| O'Brien, PJ | 1 |
| Ebel, RE | 1 |
17 other studies available for pyrazole and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Aqueous extract of Artemisia capillaris exerts hepatoprotective action in alcohol-pyrazole-fed rat model.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Artemisia; Aspartate Aminotransferases; Blood G | 2013 |
Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency.
Topics: 7-Alkoxycoumarin O-Dealkylase; Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Asparta | 2008 |
Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2009 |
Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor alpha liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Synergism; Enzyme Act | 2010 |
Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice.
Topics: Alanine Transaminase; Animals; Caspase 3; Caspase 8; Catalase; Chemical and Drug Induced Liver Injur | 2011 |
Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress.
Topics: Alanine Transaminase; Animals; Apoptosis; Arginine; Argininosuccinate Synthase; Aspartate Aminotrans | 2012 |
Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Facto | 2012 |
Endoplasmic reticulum stress due to altered cellular redox status positively regulates murine hepatic CYP2A5 expression.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP | 2004 |
Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Synergism; | 2005 |
S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Apoptosis; Chemical and Dru | 2006 |
Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
Topics: Alcohol Dehydrogenase; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Herb-Drug Interacti | 2006 |
Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5.
Topics: Alcohol Dehydrogenase; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chemical and Drug | 2006 |
S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; DNA Fragmentation; Liver; | 2007 |
Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice.
Topics: Acetone; Animals; Apoptosis; Caspase 3; Catalysis; Chemical and Drug Induced Liver Injury; Cytochrom | 2007 |
Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice.
Topics: Animals; Anthracenes; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Glutathione; | 2008 |
Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration.
Topics: Animals; Carbon Disulfide; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome | 1992 |
Pyrazole treatment of rats potentiates CCL4-but not CHCL3-hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical | 1989 |