pyrazole has been researched along with Astrocytoma in 2 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pyrazole compound 1 was further tested in a 10-dose IC(50) mode and showed an IC(50) value of 199 nM for ROS1 kinase." | 1.35 | Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor. ( Cho, SJ; El-Deeb, IM; Han, DK; Lee, HS; Lee, JY; Lee, SH; Oh, CH; Park, BS; Yoo, KH, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, BS | 1 |
| El-Deeb, IM | 1 |
| Yoo, KH | 1 |
| Oh, CH | 1 |
| Cho, SJ | 1 |
| Han, DK | 1 |
| Lee, HS | 1 |
| Lee, JY | 1 |
| Lee, SH | 1 |
| Shirakawa, H | 1 |
1 review available for pyrazole and Astrocytoma
| Article | Year |
|---|---|
[Pathophysiological significance of the canonical transient receptor potential (TRPC) subfamily in astrocyte activation].
Topics: Animals; Astrocytes; Astrocytoma; Biomarkers; Brain Injuries; Calcium; Calcium Signaling; Cell Proli | 2012 |
1 other study available for pyrazole and Astrocytoma
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor.
Topics: Antineoplastic Agents; Astrocytoma; Drug Design; Humans; Protein Kinase Inhibitors; Protein-Tyrosine | 2009 |