Page last updated: 2024-10-20

pyrazole and Astrocytoma

pyrazole has been researched along with Astrocytoma in 2 studies

1H-pyrazole : The 1H-tautomer of pyrazole.

Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Research Excerpts

ExcerptRelevanceReference
"The pyrazole compound 1 was further tested in a 10-dose IC(50) mode and showed an IC(50) value of 199 nM for ROS1 kinase."1.35Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor. ( Cho, SJ; El-Deeb, IM; Han, DK; Lee, HS; Lee, JY; Lee, SH; Oh, CH; Park, BS; Yoo, KH, 2009)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Park, BS1
El-Deeb, IM1
Yoo, KH1
Oh, CH1
Cho, SJ1
Han, DK1
Lee, HS1
Lee, JY1
Lee, SH1
Shirakawa, H1

Reviews

1 review available for pyrazole and Astrocytoma

ArticleYear
[Pathophysiological significance of the canonical transient receptor potential (TRPC) subfamily in astrocyte activation].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2012, Volume: 132, Issue:5

    Topics: Animals; Astrocytes; Astrocytoma; Biomarkers; Brain Injuries; Calcium; Calcium Signaling; Cell Proli

2012

Other Studies

1 other study available for pyrazole and Astrocytoma

ArticleYear
Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor.
    Bioorganic & medicinal chemistry letters, 2009, Aug-15, Volume: 19, Issue:16

    Topics: Antineoplastic Agents; Astrocytoma; Drug Design; Humans; Protein Kinase Inhibitors; Protein-Tyrosine

2009