pyrazole has been researched along with Alzheimer Disease in 5 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Yu, Y | 1 |
| Tu, Z | 1 |
| Mattson, MN | 1 |
| Neitzel, ML | 1 |
| Quincy, DA | 1 |
| Semko, CM | 1 |
| Garofalo, AW | 1 |
| Keim, PS | 1 |
| Konradi, AW | 1 |
| Pleiss, MA | 1 |
| Sham, HL | 1 |
| Brigham, EF | 1 |
| Goldbach, EG | 1 |
| Zhang, H | 1 |
| Sauer, JM | 1 |
| Basi, GS | 1 |
| Ghosh, AK | 1 |
| Pandey, S | 1 |
| Gangarajula, S | 1 |
| Kulkarni, S | 1 |
| Xu, X | 1 |
| Rao, KV | 1 |
| Huang, X | 1 |
| Tang, J | 1 |
| Rzepecki, P | 1 |
| Geib, N | 1 |
| Peifer, M | 1 |
| Biesemeier, F | 1 |
| Schrader, T | 1 |
| Gökhan-Kelekçi, N | 1 |
| Yabanoğlu, S | 1 |
| Küpeli, E | 1 |
| Salgin, U | 1 |
| Ozgen, O | 1 |
| Uçar, G | 1 |
| Yeşilada, E | 1 |
| Kendi, E | 1 |
| Yeşilada, A | 1 |
| Bilgin, AA | 1 |
1 review available for pyrazole and Alzheimer Disease
| Article | Year |
|---|---|
Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer's Disease and Parkinson's Disease Treatment (2011-2020).
Topics: Alzheimer Disease; Animals; Humans; Molecular Structure; Parkinson Disease; Pyrazoles | 2021 |
4 other studies available for pyrazole and Alzheimer Disease
| Article | Year |
|---|---|
Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Crystallography, X-Ray; Humans; In | 2010 |
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Catalytic Domain; Cell Line, Tumor; Crystal | 2012 |
Synthesis and binding studies of Alzheimer ligands on solid support.
Topics: Alzheimer Disease; Amination; Amyloid beta-Peptides; Ligands; Molecular Structure; Peptides; Pyrazol | 2007 |
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.
Topics: Alzheimer Disease; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Hydrogen Bonding; | 2007 |