pyrazole has been researched along with Alcoholism in 8 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Alternating intraperitoneal injections of metabolically stable tert-butanol and ethanol for 4 consecutive days resulted in a physical dependence on alcohol, which was quantified by the latency and ED50 of picrotoxin-induced CNS hyperexcitability--myoclonic and tonic seizures and mortality--during the withdrawal period." | 3.67 | Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse. ( Kovács, GL; Szabó, G; Telegdy, G, 1984) |
| "Pyrazole treatment produced an identical 3- to 4-fold increase in content and catalytic activity of P450 2E1 in the two lines." | 1.28 | The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats. ( Cederbaum, AI; Winters, DK, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Szabó, G | 1 |
| Kovács, GL | 1 |
| Telegdy, G | 1 |
| Poldrugo, F | 1 |
| Snead, OC | 1 |
| Crabbe, JC | 2 |
| Young, ER | 1 |
| Kosobud, A | 1 |
| Crawshaw, LI | 1 |
| O'Connor, CS | 1 |
| Hayteas, DL | 1 |
| Lucas, D | 1 |
| Ménez, JF | 1 |
| Berthou, F | 1 |
| Cauvin, JM | 1 |
| Deitrich, RA | 1 |
| Winters, DK | 1 |
| Cederbaum, AI | 1 |
| Lin, RC | 2 |
| Lumeng, L | 2 |
8 other studies available for pyrazole and Alcoholism
| Article | Year |
|---|---|
Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Dose-Response Relationship, Drug; Humans; Lethal D | 1984 |
Effect of ethanol and acetaldehyde on gamma-hydroxybutyric acid in rat brain and liver.
Topics: Acetaldehyde; Alcoholism; Animals; Brain; Ethanol; Humans; Hydroxybutyrates; Liver; Male; Pyrazoles; | 1984 |
Genetic correlations with ethanol withdrawal severity.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Body Temperature Regulation; Drug Tolerance; Ethan | 1983 |
Temperature regulation in mice during withdrawal from ethanol dependence.
Topics: Alcoholism; Analysis of Variance; Animals; Body Temperature; Body Temperature Regulation; Male; Mice | 1994 |
Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; Male; Me | 1992 |
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Immunoblotting; M | 1992 |
Formation of a protein-acetaldehyde adduct in liver during chronic alcohol exposure.
Topics: Acetaldehyde; Alcoholism; Animals; Cyanamide; In Vitro Techniques; Liver; Male; Molecular Weight; Pr | 1991 |
Formation of the 37KD protein-acetaldehyde adduct in liver during alcohol treatment is dependent on alcohol dehydrogenase activity.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcoholism; Animals; Cells, Cultured; | 1990 |