pyrazole-5-carboxamide has been researched along with Prostatic-Neoplasms* in 1 studies
1 other study(ies) available for pyrazole-5-carboxamide and Prostatic-Neoplasms
| Article | Year |
|---|---|
Design, Synthesis and Biological Evaluation of 1-methyl-1H-pyrazole-5-Carboxamide Derivatives as Novel Anti-Prostate Cancer Agents.
The Androgen Receptor (AR) signaling functionis a critical driving force for the progression of Prostate Cancer (PCa) to bring about anti-prostate cancer agents, and AR has been proved to be an effective therapeutic target even for Castration-Resistant Prostate Cancer (CRPC).. In order to discover novel anti-prostate cancer agents, we performed structural modifications based on the lead compounds T3 and 10e.. A set of 1-methyl- 1H-pyrazole-5-carboxamide derivatives were synthesized and evaluated for their inhibitory activities against both expressions of Prostate-Specific Antigen (PSA) and growth of PCa cell lines.. Compound H24 was found to be able to completely block PSA expression at 10μM, and showed prominent antiproliferative activity in both the LNCaP cell line (GI. These preliminary data supported a further evaluation of compound H24 as a potential agent to treat prostate cancer. Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Male; Molecular Docking Simulation; Molecular Structure; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrazoles; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |