pyrazolanthrone has been researched along with Liver Neoplasms in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 17 (56.67) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abu Rabah, RR; Al Shamma, SA; Al-Tel, TH; Anbar, HS; El-Gamal, MI; Elgendy, SM; Omar, HA; Sebastian, A; Shehata, MK; Sultan, S; Tarazi, H; Vunnam, S; Zaraei, SO | 1 |
| Fan, X; Gan, C; Qi, S; Qi, Z; Zhang, Y; Zhou, H | 1 |
| Christie, CF; Dang, Y; DeHart, DN; Fang, D; Gooz, MB; Heslop, KA; Hunt, EG; Lemasters, JJ; Maldonado, EN; Morris, ME; Rovini, A | 1 |
| Chen, M; Cheng, X; Liu, Z | 1 |
| Díaz-Ruiz, L; Jannus, F; Lupiáñez, JA; Medina-O'Donnell, M; Parra, A; Reyes-Zurita, FJ; Rivas, F; Rufino-Palomares, EE | 1 |
| Chen, A; Chen, L; Chen, S; Dai, X; He, F; Huang, C; Jiang, Y; Li, S; Li, T; Lian, J; Sun, L; Xiang, L; Xiao, H; Yan, X; Yang, M; Zhang, Y | 1 |
| Haga, Y; Kanda, T; Nakamoto, S; Nakamura, M; Sasaki, R; Takahashi, K; Wu, S; Yokosuka, O | 1 |
| Ji, L; Lu, B; Shi, L; Zhang, G; Zheng, Z | 1 |
| Clavien, PA; Graf, R; Humar, B; Langiewicz, M | 1 |
| Nazim, UM; Park, SY | 1 |
| Cao, H; Chen, X; Fu, M; He, Z; Li, X; Tang, J; Wang, Y; Zheng, SJ | 1 |
| Huang, Y; Tu, M; Wang, P; Wu, Y; Xiong, F; Zhou, C | 1 |
| Baccino, FM; Bonelli, G; Costelli, P; Khadjavi, A; Minero, VG | 1 |
| Ahn, YH; Jee, HG; Kim, HR; Kim, JB; Kim, YJ; Lee, HS; Lee, JH; Lee, M; Park, SY; Yoon, JH; Yu, SJ | 1 |
| Ahn, JS; Chin, YW; Kim, MO; Lee, HS; Moon, DO | 1 |
| Chiba, N; Kaneoka, Y; Kozawa, O; Kumada, T; Maeda, A; Matsushima-Nishiwaki, R; Nagasawa, T; Okuda, S; Toyoda, H; Yasuda, E | 1 |
| Chen, JC; Chiu, CC; Liao, MH; Lin, JJ; Wang, RY; Wu, YJ | 1 |
| Hu, KB; Jiang, LN; Jie, J; Ni, WH; Tai, GX; Wang, J; Xie, F; Yuan, HY; Zhai, XY; Zhang, NN | 1 |
| Gao, C; Herr, I; Hoffmann, K; Lin, S; Petrulionis, M; Schemmer, P | 1 |
| Cao, JP; Gao, X; Qian, AR; Shang, P; Wang, Z; Weng, YY; Xu, HY; Yang, PF; Zhang, W | 1 |
| Bruns, CJ; Camaj, P; De Toni, EN; Eichhorst, ST; Gallmeier, E; Gerbes, AL; Göke, B; Kolligs, FT; Mucha, SR; Rizzani, A; Thasler, WE | 1 |
| Hanajiri, K; Hashimoto, N; Maruyama, T; Mitsui, H; Omata, M; Sata, M | 1 |
| Asechi, H; Hatano, E; Ikai, I; Kitamura, K; Matsuzaki, K; Murata, M; Nagata, H; Narita, M; Tada, M; Tamaki, N; Uemoto, S; Yagi, S; Yanagida, A | 1 |
| Chang, WY; Choi, YH; Hyun, JW; Kim, GY; Kim, MO; Moon, DO | 1 |
| Han, GQ; Jiang, Y; Qin, CY; Zhang, SH | 1 |
| Chen, MF; Duan, F; He, J; Jiang, H; Tang, SY; Wang, Y | 1 |
| Liu, H; Ruan, J; Wei, A; Xiao, Y; Xiong, C | 1 |
| Bronk, SF; Canbay, A; Gores, GJ; Grambihler, A; Higuchi, H | 1 |
| De Toni, EN; Eichhorst, ST; Gerbes, AL; Kuntzen, C; Mucha, SR; Opelz, C; Sonuc, N | 1 |
| Biswas, KK; Hashiguchi, T; Kawahara, K; Maruyama, I; Sarker, KP; Tancharoen, S; Tancharon, S | 1 |
30 other study(ies) available for pyrazolanthrone and Liver Neoplasms
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Molecular Structure; Protein Kinase Inhibitors; Pyrazoles; Structure-Activity Relationship | 2022 |
[Eriocitrin suppresses proliferation and migration of hepatocellular carcinoma SMMC-7721 cells by promoting ROS production and activating the MAPK pathway].
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Poly(ADP-ribose) Polymerase Inhibitors; Reactive Oxygen Species | 2023 |
JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells.
Topics: Anthracenes; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Enzyme Activation; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Protein Transport; Reactive Oxygen Species; Sorafenib; Voltage-Dependent Anion Channels | 2020 |
MicroRNA-294 Promotes Cell Proliferation, Migration and Invasion in SMMC-7721 Hepatoma Carcinoma Cells by Activating the JNK/ERK Signaling Pathway.
Topics: Aged; Anthracenes; Butadienes; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Nitriles; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Up-Regulation | 2020 |
A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells.
Topics: Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Diamines; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; Polyethylene Glycols; Proto-Oncogene Proteins c-bcl-2; Receptors, Death Domain; Triterpenes; Tumor Suppressor Protein p53; Up-Regulation | 2020 |
Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells.
Topics: Acetylcysteine; Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver Neoplasms; Male; MAP Kinase Kinase 4; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Sorafenib; Tumor Burden; Xenograft Model Antitumor Assays | 2021 |
Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 7; Cell Line, Tumor; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Niacinamide; Osteopontin; Phenylurea Compounds; Phosphorylation; Proto-Oncogene Mas; RNA Interference; RNA, Small Interfering; Sorafenib | 2017 |
Andrographolide reduced VEGFA expression in hepatoma cancer cells by inactivating HIF-1α: The involvement of JNK and MTA1/HDCA.
Topics: Animals; Anthracenes; Carcinoma, Hepatocellular; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Histone Deacetylase 1; Histone Deacetylases; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Male; Mice; Mice, Nude; Neoplasms, Experimental; Repressor Proteins; Structure-Activity Relationship; Trans-Activators; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2017 |
JNK1 induces hedgehog signaling from stellate cells to accelerate liver regeneration in mice.
Topics: Animals; Anthracenes; Gene Expression Profiling; Hedgehog Proteins; Hepatectomy; Hepatic Stellate Cells; JNK Mitogen-Activated Protein Kinases; Ligation; Liver; Liver Neoplasms; Liver Regeneration; Mice; Portal Vein; Signal Transduction | 2018 |
Luteolin sensitizes human liver cancer cells to TRAIL‑induced apoptosis via autophagy and JNK‑mediated death receptor 5 upregulation.
Topics: Anthracenes; Apoptosis; Autophagy; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Luteolin; Oncogene Protein v-akt; Phosphorylation; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand | 2019 |
Inhibition of fowl adenovirus serotype 4 replication in Leghorn male hepatoma cells by SP600125 via blocking JNK MAPK pathway.
Topics: Adenoviridae Infections; Animals; Anthracenes; Aviadenovirus; Carcinoma, Hepatocellular; Cell Line, Tumor; Chickens; Interferon Type I; Liver Neoplasms; Male; MAP Kinase Signaling System; Phosphorylation; Poultry Diseases; Serogroup; Virus Replication | 2019 |
DEPDC1 promotes cell proliferation and suppresses sensitivity to chemotherapy in human hepatocellular carcinoma.
Topics: Aged; Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Hep G2 Cells; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice; Middle Aged; Neoplasm Proteins; Signal Transduction; Xenograft Model Antitumor Assays | 2019 |
JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells.
Topics: Anthracenes; Antioxidants; Apoptosis; Butylated Hydroxyanisole; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Chelating Agents; Cycloheximide; Deferoxamine; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; RNA Interference; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha; Vitamin E | 2013 |
JNK signaling in hepatocarcinoma cells is associated with the side population upon treatment with anticancer drugs.
Topics: Anthracenes; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Fluorouracil; Humans; Liver Neoplasms; MAP Kinase Kinase 4; MAP Kinase Signaling System; Paclitaxel; Proto-Oncogene Proteins c-jun; Side-Population Cells | 2015 |
Gartanin induces autophagy through JNK activation which extenuates caspase-dependent apoptosis.
Topics: Anthracenes; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MAP Kinase Kinase 4; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Xanthones | 2015 |
Phosphorylated Heat Shock Protein 20 (HSPB6) Regulates Transforming Growth Factor-α-Induced Migration and Invasion of Hepatocellular Carcinoma Cells.
Topics: Anthracenes; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; HSP27 Heat-Shock Proteins; Humans; Liver Neoplasms; MAP Kinase Kinase 4; Neoplasm Invasiveness; Neoplasm Proteins; Phosphorylation; Signal Transduction; Transforming Growth Factor alpha | 2016 |
Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction.
Topics: Animals; Anthozoa; Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Cinnamates; Diterpenes; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Mitochondria; Signal Transduction; Thiourea; Transcription Factor CHOP; Unfolded Protein Response | 2016 |
Targeting MUC1 and JNK by RNA interference and inhibitor inhibit the development of hepatocellular carcinoma.
Topics: Animals; Anthracenes; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Mucin-1; RNA Interference; RNA, Small Interfering; Transforming Growth Factor beta | 2017 |
Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma.
Topics: Anthracenes; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 4; Melatonin; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Signal Transduction; Sorafenib | 2017 |
Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells.
Topics: Anthracenes; Basigin; Carcinoma, Hepatocellular; Cytoskeleton; Down-Regulation; Flow Cytometry; Focal Adhesion Kinase 1; Gelatinases; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phosphorylation; RNA Interference; Tumor Cells, Cultured; Vinculin | 2008 |
JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.
Topics: Animals; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Cycle; Cell Line, Tumor; Enzyme Activation; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Mice; Mice, Knockout; Mice, Transgenic; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand | 2009 |
Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Dose-Response Relationship, Drug; Injections, Intralesional; JNK Mitogen-Activated Protein Kinases; Liver; Liver Neoplasms; Male; Proliferating Cell Nuclear Antigen; Protein Kinase Inhibitors; Rats; Rats, Wistar; Time Factors; Ultrasonography | 2009 |
Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma.
Topics: Animals; Anthracenes; Carcinoma, Hepatocellular; Genes, Tumor Suppressor; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Male; Rats; Rats, Wistar; Signal Transduction; Smad3 Protein | 2009 |
Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cell Proliferation; Cell Survival; Chalcones; Dose-Response Relationship, Drug; Enzyme Activation; G2 Phase; Glutathione; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Reactive Oxygen Species | 2010 |
Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma.
Topics: Anthracenes; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Cell Line, Tumor; Eukaryotic Initiation Factor-4E; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Metastasis; Oxidative Stress; Phosphorylation; RNA-Binding Proteins | 2010 |
Icaritin induces apoptosis of HepG2 cells via the JNK1 signaling pathway independent of the estrogen receptor.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Drugs, Chinese Herbal; Epimedium; Flavonoids; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Mitogen-Activated Protein Kinases; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Receptors, Estrogen; Signal Transduction | 2010 |
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Survival; Cyclohexanones; Enzyme Activation; Flavones; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species | 2011 |
Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1.
Topics: Anthracenes; Base Sequence; Bile Acids and Salts; Binding Sites; Carcinoma, Hepatocellular; Consensus Sequence; Deoxycholic Acid; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Liver Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Sp1 Transcription Factor; Transfection; Tumor Cells, Cultured | 2004 |
Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest.
Topics: Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; fas Receptor; G2 Phase; Humans; Jurkat Cells; Liver Neoplasms; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Phosphorylation; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Transcription, Genetic; Tumor Suppressor Protein p53 | 2005 |
Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.
Topics: Alkaloids; Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Benzylisoquinolines; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Line, Tumor; Collagen Type XI; Cytochromes c; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species | 2006 |