pyrazolanthrone has been researched along with Disease Models, Animal in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 27 (36.99) | 29.6817 |
| 2010's | 36 (49.32) | 24.3611 |
| 2020's | 10 (13.70) | 2.80 |
| Authors | Studies |
|---|---|
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cai, WJ; Lan, CN; Shi, J; Yi, ZJ | 1 |
| Han, X; Luo, X; Mao, Q; Peng, B; Peng, C; Wu, S; Zhang, H | 1 |
| Bai, B; Guo, L; Liang, G; Shan, X; Xiao, Z; Xu, F; Zhang, B; Zhang, Y; Zhao, Y; Zhu, X | 1 |
| Chen, Y; Gao, Y; Hai, Y; Liao, Y; Liu, K; Liu, Q; Tang, X; Wang, H; Wang, P; Wang, XJ; Wong, CCL; Yao, J; Zhang, J | 1 |
| Anbazhakan, S; Botchwey, EA; Cai, S; Clark, AA; Feng, Y; Gleason, RL; Huo, Y; Keegan, PM; Omojola, VO; Platt, MO; Rivera, CP; Selma, J; Song, H; Tan, W | 1 |
| Ji, Z; Liu, Z; Xia, Z; Xu, H; Xu, R; Xu, S; Zhao, W | 1 |
| Cheng, Y; Liu, Y; Pan, Q; Zhang, Y | 1 |
| Huang, D; Luo, ZZ; Tang, B; Yu, SC; Zhou, B | 1 |
| Chen, X; Li, J; Mao, M; Peng, C; Tang, N; Wang, Y; Wu, Y; Zhang, W; Zhou, Y | 1 |
| Hu, Y; Li, G; Li, Y; Tang, Y; Wang, M; Yang, G | 1 |
| Abid, MN; Ahmad, A; Khan, M; Kim, MO; Rehman, SU; Yoon, GH | 1 |
| Chen, J; Dong, J; Fu, C; Guo, Z; Li, N; Liu, Y; Wang, R; Wang, S; Yang, J; Yuan, Y; Zhang, Y | 1 |
| Armstead, WM; Cines, DB; Hekierski, H; Higazi, AA; Pastor, P; Yarovoi, S | 1 |
| Ding, K; Liu, Z; Xu, Y; Zhang, H; Zhang, W; Zhang, Y; Zhao, Q | 1 |
| Cai, J; Chen, F; Lang, W; Zhong, J; Zhu, J | 1 |
| Kitanaka, C; Kurachi, H; Ohta, T; Okada, M; Seino, M; Seino, S; Shibuya, K; Suzuki, S | 1 |
| Fang, L; Liu, RY; Shen, QY; Wu, HM | 1 |
| Alfonso, A; Alonso, E; Botana, LM; Ebel, R; Jaspars, M; Leirós, M; Rateb, ME | 1 |
| Chen, CX; Li, JM; Li, SX; Zhang, P; Zhao, YN | 1 |
| Bulut, G; Dönmez, YB; Erten, R; Kurdoglu, M; Kurdoglu, Z | 1 |
| Alarcón-Vila, C; Baulies, A; Caballeria, J; Casas, J; Elena, M; Fabriàs, G; Fernandez-Checa, JC; García-Ruiz, C; Martínez, L; Torres, S | 1 |
| Abdollahi, M; Aliaghaei, A; Ghahremani, MH; Gholami, M; Guan, J; Khalaj, S; Khodagholi, F; Mohammadi, M; Sharifzadeh, M; Taghizadeh, GH; Yans, A | 1 |
| Clark, AF; Kim, BJ; Liu, Y; Pang, IH; Silverman, SM; Wordinger, RJ | 1 |
| Changlong, Z; Guangwei, Z; Xiaochuan, S; Xiaohui, X; Xuenong, H; Yanfeng, X | 1 |
| Cheunsuchon, B; Chuncharunee, A; Limjindaporn, T; Noisakran, S; Sreekanth, GP; Yenchitsomanus, PT | 1 |
| Behren, A; Iftner, T; Mühlen, S; Plinkert, PK; Simon, C | 1 |
| Jiao, BM; Li, ZL; Qian, HJ; Su, L; Zheng, JS | 1 |
| Daniels, RW; DiAntonio, A; Milbrandt, J; Miller, BR; Press, C; Sasaki, Y | 1 |
| Li, H; Wang, Y; Wei, Z; Zhang, Y; Zhang, Z; Zhou, H | 1 |
| Callahan, LA; Ji, X; Supinski, GS | 1 |
| de Borst, MH; Hamming, I; Klok, PA; Kok, RJ; Navis, G; Prakash, J; Sandovici, M; van Goor, H | 1 |
| Bataller, R; Colmenero, J; De Minicis, S; Gwak, GY; Kluwe, J; Mencin, A; Osterreicher, CH; Pradere, JP; Schwabe, RF | 1 |
| Hu, YB; Liu, XY | 1 |
| Li, Q; Li, WM; Zhang, J; Zou, P | 1 |
| Calvo, JJ; Mangas, A; Pérez, N; Sánchez-Bernal, C; Sánchez-Yagüe, J; Sardina, JL; Sarmiento, N | 1 |
| Chen, LW; Chen, PH; Hsu, CM; Tseng, HT | 1 |
| Armstead, WM; Cines, DB; Higazi, AA; Kiessling, JW; Riley, J | 2 |
| Azizi, P; Haghparast, A; Khodagholi, F; Motamedi, F; Ramin, M | 1 |
| Bedja, D; Chen, Y; Cohn, RD; Dietz, HC; Doyle, JJ; Habashi, JP; Holm, TM; Judge, DP; Kim, D; Lindsay, ME; Loeys, BL; Marugan, JJ; Patnaik, S; Schoenhoff, F; Thomas, CJ; van Erp, C | 1 |
| Li, B; Li, Y; Liu, C; Pang, IH; Shen, J; Sun, H; Tang, X; Wang, Y | 1 |
| Balkany, TJ; Bas, E; Dinh, CT; Eshraghi, AA; Hoosien, G; Ramsay, S; Van De Water, TR | 1 |
| Kishima, H; Lee, S; Nakamura, Y; Sato, A; Ueno, M; Yamashita, T; Yoshimine, T; Yoshimura, K | 1 |
| Chang, KC; Jun, MS; Kim, HJ; Kim, HS; Kim, YM; Kim, YS; Lee, JH; Lee, KR; Park, EJ | 1 |
| Chen, M; Chen, S; Liu, M; Shi, L; Zou, X | 1 |
| Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Mizokami, SS; Pavao-de-Souza, GF; Sanson, JS; Tedeschi, GC; Verri, WA; Zarpelon, AC | 1 |
| Cho, KS; Han, SY; Hong, YK; Jeon, S; Kim, ST; Kim, YK; Koo, BS; Lee, JH; Lee, S; Park, SH | 1 |
| Antoccia, A; Berardinelli, F; Castedo, M; Galluzzi, L; Harper, F; Jemaà, M; Kepp, O; Kroemer, G; Lissa, D; Malik, SA; Mariño, G; Pierron, G; Rello-Varona, S; Schlemmer, F; Senovilla, L; Tailler, M; Vitale, I | 1 |
| Cui, JZ; Gao, JL; Hong, MY; Li, R; Tian, YX; Wang, H; Wang, HT | 1 |
| Chen, D; Guan, JH; Liu, YH; Peng, YT; Song, L; Wei, XT; Yuan, JW | 1 |
| Arai, K; Fujiwara, N; Ji, X; Liu, X; Lo, EH; Luo, Y; Murata, Y; Seo, JH; Terasaki, Y; Yan, F | 1 |
| Ai, X; Beyer, EC; Fast, VG; Kong, W; Walcott, G; Yan, J; Zhang, Q | 1 |
| Genade, S; Hattingh, S; Huisamen, B; Lochner, A; Marais, E; Moolman, JA | 1 |
| Altavilla, D; Bitto, A; Famulari, C; Macrì, A; Marini, H; Minutoli, L; Passaniti, M; Seminara, P; Squadrito, F; Venuti, FS; Versaci, A | 1 |
| Green, K; Iredale, JP; Mann, DA; Marek, CJ; May, MJ; Meso, M; Millward-Sadler, H; Oakley, F; Wright, MC; Zhou, X | 1 |
| Guan, QH; Hao, ZB; Pei, DS; Xu, TL; Zhang, GY; Zhang, QG | 1 |
| Abbas, S; Abu-Amer, Y; Dai, S; Hirayama, T; Yamanaka, Y | 1 |
| Guan, QH; Pei, DS; Xu, TL; Zhang, GY | 1 |
| Bennett, BL; Kitazaki, S; Mitsuyama, K; Sata, M; Satoh, Y; Suzuki, A; Takeda, T; Tomiyasu, N; Toyonaga, A; Tsuruta, O | 1 |
| Assi, K; Gómez-Muñoz, A; Owen, D; Pillai, R; Salh, B | 1 |
| Lindsay, TF; Verma, S | 1 |
| Gaarde, WA; Gunawan, BK; Han, D; Hanawa, N; Kaplowitz, N; Liu, ZX | 1 |
| Arenas, E; Castelo-Branco, G; Parish, C; Rawal, N | 1 |
| Davis, RJ; Flavell, RA; Frew, J; Henderson, NC; Mackinnon, AC; Pollock, KJ; Sethi, T; Simpson, KJ | 1 |
| Aoyagi, Y; Honda, Y; Ichida, T; Matsuda, Y; Suzuki, K; Takamura, M; Tamura, Y; Yamagiwa, S | 1 |
| Chang, WJ; Chen, LW; Chen, PH; Hsu, CM; Karin, M; Wang, JS | 1 |
| Guan, QH; Ji, HX; Pei, DS; Wang, Y; Xing, SH | 1 |
| Davies, MG; Nicholl, SM; Qi, Y; Roztocil, E; Zou, Y | 1 |
| Tian, QY; Wang, YS; Wei, ZF; Zhang, YX; Zhou, HX; Zhou, JP | 1 |
| Farivar, AS; McCourtie, AS; Merry, HE; Mulligan, MS; Wolf, PS | 1 |
| Cahill, J; Calvert, JW; Colohan, AR; Yamaguchi-Okada, M; Yatsushige, H; Zhang, JH; Zhou, C | 1 |
73 other study(ies) available for pyrazolanthrone and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.
Topics: Animals; Anthracenes; Autophagy; Butadienes; Disease Models, Animal; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osteoarthritis; Protein Kinase Inhibitors; Pyridines; Rabbits; Severity of Illness Index | 2021 |
JNK signaling-dependent regulation of histone acetylation are involved in anacardic acid alleviates cardiomyocyte hypertrophy induced by phenylephrine.
Topics: Acetylation; Anacardic Acids; Animals; Anthracenes; Cardiomegaly; China; Disease Models, Animal; Female; Histone Acetyltransferases; Histones; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; p300-CBP Transcription Factors; Phenylephrine; Primary Cell Culture; Signal Transduction | 2021 |
Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Anthracenes; Cells, Cultured; Curcumin; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Injections, Intravenous; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Phosphorylation; Structure-Activity Relationship | 2019 |
c-Jun NH
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Liver; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; NF-E2-Related Factor 2; Phosphorylation; Protein Domains; Ubiquitination | 2020 |
Sickle Cell Anemia Mediates Carotid Artery Expansive Remodeling That Can Be Prevented by Inhibition of JNK (c-Jun N-Terminal Kinase).
Topics: Anemia, Sickle Cell; Animals; Anthracenes; Carotid Arteries; Carotid Artery Diseases; Cathepsin K; Collagen; Disease Models, Animal; Elastin; Hemoglobins; Homozygote; Humans; JNK Mitogen-Activated Protein Kinases; Mice, Transgenic; Mutation; Protein Kinase Inhibitors; Proteolysis; Signal Transduction; Time Factors; Vascular Remodeling | 2020 |
Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stress.
Topics: Acetylcysteine; Animals; Anthracenes; Antioxidants; Bupivacaine; Cell Line, Tumor; Cyclic N-Oxides; Disease Models, Animal; Gene Knockdown Techniques; Humans; Injections, Spinal; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mitochondria; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Rats; Reactive Oxygen Species; RNA, Small Interfering; Superoxide Dismutase; Transcriptional Activation | 2020 |
Effects of SP600125 and hypothermic machine perfusion on livers donated after cardiac death in a pig allograft transplantation model.
Topics: Allografts; Animals; Anthracenes; Cold Temperature; Death; Disease Models, Animal; Liver Transplantation; Organ Preservation; Perfusion; Reperfusion Injury; Swine; Swine, Miniature | 2021 |
Cigarette smoke extract promotes DNA methyltransferase 3a expression in dendritic cells, inducing Th-17/Treg imbalance via the c-Jun/allograft inflammatory factor 1 axis.
Topics: Allografts; Animals; Anthracenes; Calcium-Binding Proteins; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Dendritic Cells; Disease Models, Animal; DNA Methyltransferase 3A; Enzyme Inhibitors; Male; Mice; Mice, Inbred BALB C; Microfilament Proteins; Proto-Oncogene Proteins c-jun; Pulmonary Disease, Chronic Obstructive; Signal Transduction; Smoke; Smoking; T-Lymphocytes, Regulatory; Tetrazolium Salts; Th17 Cells; Thiazoles | 2021 |
Fine particulate matter (PM2.5) promotes IgE-mediated mast cell activation through ROS/Gadd45b/JNK axis.
Topics: Animals; Anthracenes; Antigens, Differentiation; Cell Degranulation; Cell Line; Cell Line, Tumor; Dermatitis, Allergic Contact; Disease Models, Animal; Electron Transport; Humans; Immunoglobulin E; JNK Mitogen-Activated Protein Kinases; Male; Mast Cells; Mice; Mitochondria; Particulate Matter; Passive Cutaneous Anaphylaxis; Rats; Reactive Oxygen Species; RNA-Seq; Signal Transduction; Skin | 2021 |
Protective effects of SP600125 on mice infected with H1N1 influenza A virus.
Topics: Animals; Anthracenes; Disease Models, Animal; Female; Gene Expression Regulation; Influenza A Virus, H1N1 Subtype; Lung; Mice; Orthomyxoviridae Infections; Proto-Oncogene Proteins c-jun; Random Allocation; Treatment Outcome; Virus Replication | 2021 |
Inhibition of c-Jun N-Terminal Kinase Protects Against Brain Damage and Improves Learning and Memory After Traumatic Brain Injury in Adult Mice.
Topics: Amyloid beta-Peptides; Animals; Anthracenes; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fluoresceins; JNK Mitogen-Activated Protein Kinases; Learning Disabilities; Maze Learning; Mice; Mice, Inbred C57BL; Peptide Fragments; Psychomotor Performance | 2018 |
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Body Weight; Bone Morphogenetic Protein 4; Carrier Proteins; Chronic Disease; Disease Models, Animal; Endothelium, Vascular; Flavonoids; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; In Vitro Techniques; Kidney; Male; Nitric Oxide Synthase Type III; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats, Sprague-Dawley; Surgical Instruments; Systole; Vasodilation | 2018 |
Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK.
Topics: Animals; Anthracenes; Cerebral Cortex; Disease Models, Animal; Endothelin-1; Hippocampus; Homeostasis; Interleukin-6; Necrosis; Oxazolidinones; Random Allocation; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Stroke; Swine; Tissue Plasminogen Activator; Up-Regulation | 2019 |
Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Case-Control Studies; Cell Line; Cell Proliferation; Disease Models, Animal; Female; HMGB2 Protein; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protein Kinase Inhibitors; Pyrrolidines; Rats, Sprague-Dawley; Signal Transduction; Thiocarbamates; Time Factors; Transcription Factor RelA; Young Adult | 2018 |
EVI-1 modulates arsenic trioxide induced apoptosis through JNK signalling pathway in leukemia cells.
Topics: Animals; Anthracenes; Apoptosis; Arsenic Trioxide; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Leukemic; Humans; Leukemia; MAP Kinase Signaling System; MDS1 and EVI1 Complex Locus Protein; Models, Biological; Neoplasm Proteins; RNA, Messenger; Zebrafish | 2019 |
Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; Female; Gene Knockdown Techniques; Heterografts; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Neoplastic Stem Cells; Ovarian Neoplasms; Signal Transduction; Spheroids, Cellular; Tumor Burden; Tumor Cells, Cultured | 2014 |
SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model.
Topics: Acute Disease; Animals; Anthracenes; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Female; Hypersensitivity; Immunoglobulin E; Inflammation; JNK Mitogen-Activated Protein Kinases; Lung; Mice, Inbred C57BL; Mucus; Ovalbumin; Phosphorylation; Toll-Like Receptor 9 | 2015 |
The Streptomyces metabolite anhydroexfoliamycin ameliorates hallmarks of Alzheimer's disease in vitro and in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anthracenes; Antipsychotic Agents; Aspartic Acid Endopeptidases; Brain; Cell Line, Tumor; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; MAP Kinase Kinase Kinases; Mice; Mice, Transgenic; Mutation; Neuroblastoma; Peptide Fragments; Presenilin-1; Prodigiosin; tau Proteins | 2015 |
Hypertension-mediated enhancement of JNK activation in association with endoplasmic reticulum stress in rat model hippocampus with cerebral ischemia-reperfusion.
Topics: Animals; Anthracenes; Brain Ischemia; CA1 Region, Hippocampal; Disease Models, Animal; Endoplasmic Reticulum Stress; Enzyme Activation; Heat-Shock Proteins; Hippocampus; Hypertension; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reperfusion Injury; Transcription Factor CHOP | 2015 |
Effects of jnk inhibitor on inflammation and fibrosis in the ovary tissue of a rat model of polycystic ovary syndrome.
Topics: Animals; Anthracenes; Disease Models, Animal; Female; Fibrosis; Immunohistochemistry; Inflammation; MAP Kinase Kinase 4; Polycystic Ovary Syndrome; Protein Kinase Inhibitors; Rats; Rats, Wistar | 2015 |
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis.
Topics: Animals; Anthracenes; Apoptosis; Ceramides; Cholesterol; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Acids, Monounsaturated; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Lipodystrophy; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Myristic Acid; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Oxidoreductases; Palmitic Acid; Protein Kinase Inhibitors; Reactive Oxygen Species; Ruthenium Red; Sphingosine N-Acyltransferase; Time Factors | 2015 |
Reduction of autophagy markers mediated protective effects of JNK inhibitor and bucladesine on memory deficit induced by Aβ in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthracenes; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 7; Beclin-1; Bucladesine; Disease Models, Animal; Drug Therapy, Combination; JNK Mitogen-Activated Protein Kinases; Male; Maze Learning; Memory Disorders; Microtubule-Associated Proteins; Neuroprotective Agents; Protein Kinase Inhibitors; Rats, Wistar; Spatial Memory | 2016 |
In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells.
Topics: Animals; Anthracenes; Apoptosis; Disease Models, Animal; Female; Intraocular Pressure; JNK Mitogen-Activated Protein Kinases; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Diseases; Retinal Ganglion Cells | 2016 |
The Role of Platelet-Derived Growth Factor Receptor in Early Brain Injury Following Subarachnoid Hemorrhage.
Topics: Animals; Anthracenes; Antineoplastic Agents; Brain Edema; Brain Injuries; Caspase 3; Disease Models, Animal; Double-Blind Method; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; Imatinib Mesylate; In Situ Nick-End Labeling; Male; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Subarachnoid Hemorrhage | 2016 |
JNK1/2 inhibitor reduces dengue virus-induced liver injury.
Topics: Animals; Anthracenes; Apoptosis; Caspases; Dengue Virus; Disease Models, Animal; Leukopenia; Liver; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Severe Dengue; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Viral Load | 2017 |
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Topics: Animals; Anthracenes; Binding Sites; Carcinoma; Cell Line; Cell Line, Tumor; Cottontail rabbit papillomavirus; Disease Models, Animal; DNA Mutational Analysis; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Rabbits; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Viral Proteins | 2009 |
[The influence of JNK inhibitor on hemodynamics after ischemia/reperfusion injury to the heart in rats].
Topics: Animals; Anthracenes; Disease Models, Animal; Hemodynamics; JNK Mitogen-Activated Protein Kinases; Male; Myocardial Reperfusion Injury; Protein Kinase Inhibitors; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley | 2008 |
A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.
Topics: Animals; Animals, Genetically Modified; Anthracenes; Axons; Axotomy; Cells, Cultured; Disease Models, Animal; Drosophila; Embryo, Mammalian; Enzyme Inhibitors; Ganglia, Spinal; Green Fluorescent Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Olfactory Receptor Neurons; Sciatic Nerve; Wallerian Degeneration | 2009 |
JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anthracenes; Cell Death; Cyclooxygenase 2; Disease Models, Animal; Dopamine; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Movement Disorders; Neurons; Parkinson Disease; Parkinsonian Disorders; Phosphorylation; Proto-Oncogene Proteins c-jun; Random Allocation; Substantia Nigra | 2009 |
The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation.
Topics: Animals; Anthracenes; Caspase 8; Cell Line; Cytokines; Diaphragm; Disease Models, Animal; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle Fibers, Skeletal; Muscle Strength; Muscle Weakness; Phosphorylation; Protein Kinase Inhibitors; Sepsis; Time Factors; Transfection | 2009 |
c-Jun NH2-terminal kinase is crucially involved in renal tubulo-interstitial inflammation.
Topics: Adolescent; Adult; Animals; Anthracenes; Blotting, Western; Cell Line; Chemokine CCL2; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Epithelial Cells; Female; Gene Expression; Humans; Immunohistochemistry; Inflammation; JNK Mitogen-Activated Protein Kinases; Kidney Diseases; Kidney Tubules; Macrophages; Male; Middle Aged; Nephritis, Interstitial; Protein Kinase Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Young Adult | 2009 |
Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition.
Topics: Angiotensin II; Animals; Anthracenes; Carrier Proteins; Cell Division; Cells, Cultured; Disease Models, Animal; Fatty Liver; Fibroblasts; Hepatic Stellate Cells; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Mitogen-Activated Protein Kinase 9; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Transforming Growth Factor beta | 2010 |
Protective effects of SP600125 in a diet-induced rat model of non-alcoholic steatohepatitis.
Topics: Animals; Anthracenes; Blotting, Western; Dietary Fats; Disease Models, Animal; Fatty Liver; Immunoprecipitation; Insulin Resistance; Liver; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome | 2009 |
[Pathogenetic role of tissue factor in endothelial-injury in graft-versus-host disease].
Topics: Animals; Anthracenes; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium; Endothelium, Vascular; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Imidazoles; Interferon-gamma; Interleukin-6; Mice; Mitogen-Activated Protein Kinases; Pyridines; T-Lymphocytes; Thromboplastin; Tumor Necrosis Factor-alpha | 2009 |
Rolipram and SP600125 suppress the early increase in PTP1B expression during cerulein-induced pancreatitis in rats.
Topics: Animals; Anthracenes; Ceruletide; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neutropenia; Pancreatitis; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Rats, Wistar; Rolipram; Vinblastine | 2010 |
Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells.
Topics: Animals; Anthracenes; Blotting, Western; Dimethyl Sulfoxide; Disease Models, Animal; Hematopoiesis; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Leflunomide; Lung Injury; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; NF-kappa B; Nitric Oxide Synthase; Peritonitis; Peroxynitrous Acid; Rhodamines; Signal Transduction; Transcription Factor AP-1 | 2010 |
PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.
Topics: Animals; Animals, Newborn; Anthracenes; Blood Pressure; Carbon Dioxide; Cardiovascular Agents; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Hypercapnia; Hypotension; Hypoxia-Ischemia, Brain; Imidazoles; Injections, Intravenous; Isoproterenol; JNK Mitogen-Activated Protein Kinases; Male; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pia Mater; Protein Kinase Inhibitors; Pyridines; Swine; Time Factors; Up-Regulation; Vasodilation; Vasodilator Agents | 2010 |
Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK.
Topics: Animals; Animals, Newborn; Anthracenes; Cerebrovascular Circulation; Disease Models, Animal; Erythrosine; Female; Fibrinolytic Agents; Imidazoles; Intracranial Thrombosis; JNK Mitogen-Activated Protein Kinases; Lasers, Solid-State; Male; p38 Mitogen-Activated Protein Kinases; Peptides; Protein Kinase Inhibitors; Pyridines; Recombinant Proteins; Swine; Time Factors; Tissue Plasminogen Activator; Vasoconstriction; Vasodilation | 2010 |
Inhibition of JNK phosphorylation reverses memory deficit induced by β-amyloid (1-42) associated with decrease of apoptotic factors.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Anthracenes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cyclooxygenase 2; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hippocampus; In Situ Nick-End Labeling; Male; MAP Kinase Kinase 4; Maze Learning; Memory Disorders; Neurons; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Statistics, Nonparametric | 2011 |
Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.
Topics: Animals; Anthracenes; Aorta; Aortic Aneurysm; Diphenylamine; Disease Models, Animal; Disease Progression; Enzyme Activation; Losartan; MAP Kinase Signaling System; Marfan Syndrome; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Protein Kinase Inhibitors; Smad2 Protein; Smad4 Protein; Sulfonamides; Transforming Growth Factor beta | 2011 |
Protective effect of a JNK inhibitor against retinal ganglion cell loss induced by acute moderate ocular hypertension.
Topics: Animals; Anthracenes; Cell Count; Cell Survival; Disease Models, Animal; Electroretinography; Glaucoma; Intraocular Pressure; JNK Mitogen-Activated Protein Kinases; Male; Ocular Hypertension; Optic Nerve; Protein Kinase Inhibitors; Rats; Rats, Wistar; Retina; Retinal Ganglion Cells; Tonometry, Ocular | 2011 |
Inhibition of the JNK signal cascade conserves hearing against electrode insertion trauma-induced loss.
Topics: Animals; Anthracenes; Apoptosis; Auditory Threshold; Cells, Cultured; Disease Models, Animal; Electrodes, Implanted; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; In Vitro Techniques; Injections, Intralesional; MAP Kinase Kinase 4; MAP Kinase Signaling System; Organ of Corti; Rats; Reference Values; Sensitivity and Specificity; Tumor Necrosis Factor-alpha | 2010 |
c-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice.
Topics: Animals; Anthracenes; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinase 8; Nerve Regeneration; Paralysis; Recovery of Function; Spinal Cord Injuries; Wallerian Degeneration | 2011 |
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Ethanol; Flavonoids; Flowers; Genetic Vectors; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Morpholines; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Protein Transport; Prunella; Pyridines; Sepsis; Signal Transduction; Transfection | 2012 |
Effects of c-Jun N-terminal kinase signaling pathway on severe acute pancreatitis-associated lung injury.
Topics: Acute Disease; Amylases; Animals; Anthracenes; Disease Models, Animal; Intercellular Adhesion Molecule-1; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lung; Lung Injury; Male; Pancreas; Pancreatitis; Peroxidase; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Taurocholic Acid; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.
Topics: Acetic Acid; Androstadienes; Animals; Anthracenes; Benzoquinones; Disease Models, Animal; Flavonoids; Imidazoles; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Microglia; Nociception; Nociceptive Pain; Pain; Pain Measurement; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Spinal Cord; Wortmannin | 2012 |
Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthracenes; Apoptosis; Brain; Caspases; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Forkhead Transcription Factors; MAP Kinase Kinase 4; Neurons; Peptide Fragments; Protein Kinase Inhibitors; Signal Transduction | 2012 |
Selective killing of p53-deficient cancer cells by SP600125.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Mice; Microscopy, Video; Neoplasms; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2012 |
[Effect of expression of c-jun N-terminal kinase on neuron autophagy following diffuse brain injury in rats].
Topics: Animals; Anthracenes; Autophagy; Brain Injuries; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Male; Neurons; Rats; Rats, Sprague-Dawley | 2012 |
Inhibition of c-Jun N-terminal kinase prevents blood-brain barrier disruption and normalizes the expression of tight junction proteins clautin-5 and ZO-1 in a rat model of subarachnoid hemorrhage.
Topics: Animals; Anthracenes; Apoptosis; Blood-Brain Barrier; Brain; Claudin-5; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Male; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Signal Transduction; Subarachnoid Hemorrhage; Tight Junctions; Zonula Occludens-1 Protein | 2012 |
Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia.
Topics: Animals; Anthracenes; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinase 9; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley | 2012 |
c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.
Topics: Aging; Animals; Anisomycin; Anthracenes; Arrhythmias, Cardiac; Atrial Fibrillation; Cell Communication; Cells, Cultured; Connexin 43; Disease Models, Animal; Enzyme Inhibitors; Heart Atria; Heart Conduction System; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Male; Rabbits | 2013 |
Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK.
Topics: Animals; Anisomycin; Anthracenes; Cardiac Output; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Heart Rate; Imidazoles; Ischemic Preconditioning, Myocardial; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar | 2003 |
Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.
Topics: Amylases; Analysis of Variance; Animals; Anthracenes; Blotting, Western; Ceruletide; Disease Models, Animal; Edema; Enzyme Activation; Histological Techniques; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Lipase; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Oligonucleotides; Pancreas; Pancreatitis; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Tumor Necrosis Factor-alpha | 2004 |
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.
Topics: Animals; Anthracenes; Apoptosis; Cell Culture Techniques; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Agents; Humans; Liver; Liver Cirrhosis; Male; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfasalazine | 2005 |
The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways.
Topics: Analysis of Variance; Animals; Anthracenes; Blotting, Western; Cell Count; Cell Death; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Immunoprecipitation; Ischemic Attack, Transient; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Neurons; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Staining and Labeling; Time Factors | 2005 |
Inhibition of inflammatory bone erosion by constitutively active STAT-6 through blockade of JNK and NF-kappaB activation.
Topics: Animals; Anthracenes; Arthritis, Experimental; Bone Marrow Cells; Bone Resorption; Carrier Proteins; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; JNK Mitogen-Activated Protein Kinases; Leg Bones; Macrophages; MAP Kinase Kinase 4; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; STAT6 Transcription Factor; Trans-Activators | 2005 |
Brain ischemia/reperfusion-induced expression of DP5 and its interaction with Bcl-2, thus freeing Bax from Bcl-2/Bax dimmers are mediated by c-Jun N-terminal kinase (JNK) pathway.
Topics: Analysis of Variance; Animals; Anthracenes; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blotting, Western; Brain Ischemia; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Male; Neuropeptides; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion; Time Factors | 2006 |
Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease.
Topics: Animals; Anthracenes; Case-Control Studies; Colitis; Cytokines; Disease Models, Animal; Female; Gastric Mucosa; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Monocytes; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2006 |
The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis.
Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Macrophages; Mice; Mice, Inbred C57BL; Signal Transduction; Tumor Necrosis Factor-alpha; Weight Loss | 2006 |
Regression of aortic aneurysms through pharmacologic therapy?
Topics: Animals; Anthracenes; Aortic Aneurysm, Abdominal; Aortic Rupture; Disease Models, Animal; Extracellular Matrix; Gene Expression Profiling; Humans; MAP Kinase Kinase 4; Matrix Metalloproteinase 9; Mice | 2006 |
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anthracenes; Apoptosis; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mitochondria, Liver | 2006 |
Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats.
Topics: Animals; Anthracenes; Cell Survival; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Graft Survival; JNK Mitogen-Activated Protein Kinases; Mesencephalon; Neurons; Parkinson Disease; Rats; Tyrosine 3-Monooxygenase | 2007 |
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Biopsy; Carbon Tetrachloride; Cell Death; Disease Models, Animal; Drug Administration Schedule; Enzyme Activation; Enzyme Inhibitors; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Liver Failure, Acute; Mice; Mice, Inbred C57BL; Mice, Knockout; Tumor Necrosis Factor-alpha | 2007 |
An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins.
Topics: Alanine Transaminase; Animals; Anthracenes; Apoptosis; Aspartate Aminotransferases; bcl-Associated Death Protein; BH3 Interacting Domain Death Agonist Protein; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Enzyme Inhibitors; Galactosamine; Hepatocytes; Injections, Intraperitoneal; Injections, Subcutaneous; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Liver Failure; Longevity; Male; Mice; Mice, Inbred BALB C; Peptide Fragments; Proto-Oncogene Proteins | 2007 |
IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation.
Topics: Animals; Anthracenes; Apoptosis; bcl-X Protein; Burns; Caspase 3; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; I-kappa B Kinase; Imidazoles; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Pyridines; RNA, Messenger; Signal Transduction | 2007 |
SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis.
Topics: Animals; Anthracenes; Apoptosis; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Kidney; Kidney Diseases; Necrosis; Protective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2007 |
Patterns of kinase activation induced by injury in the murine femoral artery.
Topics: Animals; Anthracenes; Calcium Signaling; Cell Division; Disease Models, Animal; Femoral Artery; Flavonoids; Hyperplasia; Male; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Plasminogen Activator Inhibitor 1; Tunica Intima; Urokinase-Type Plasminogen Activator | 2007 |
[Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anthracenes; Blotting, Western; Cell Death; Cyclooxygenase 2; Disease Models, Animal; Dopamine; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neurons; Parkinson Disease; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-jun; Substantia Nigra | 2007 |
Stress-activated protein kinase inhibition to ameliorate lung ischemia reperfusion injury.
Topics: Animals; Anthracenes; Blotting, Western; Bronchoalveolar Lavage Fluid; Butadienes; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Immunohistochemistry; Inflammation Mediators; Lung Diseases; Male; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; Peroxidase; Phosphorylation; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion Injury; Sensitivity and Specificity | 2008 |
Inhibition of c-Jun N-terminal kinase pathway attenuates cerebral vasospasm after experimental subarachnoid hemorrhage through the suppression of apoptosis.
Topics: Animals; Anthracenes; Apoptosis; Basilar Artery; Disease Models, Animal; Dogs; JNK Mitogen-Activated Protein Kinases; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2008 |