pyrazolanthrone has been researched along with Alzheimer Disease in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kluftinger, A; Little, JP; Mah, D; Simtchouk, S; Wan, Z | 1 |
| Bai, M; Du, Y; Li, Z; Miao, J; Wang, M; Zhang, W; Zhang, Z; Zhou, Q | 1 |
| Alfonso, A; Alonso, E; Botana, LM; Ebel, R; Jaspars, M; Leirós, M; Rateb, ME | 1 |
| Ahn, JH; Kim, DH; Kim, HJ; Kim, NY; So, SP; Yoon, SY | 1 |
| Abdollahi, M; Aliaghaei, A; Ghahremani, MH; Gholami, M; Guan, J; Khalaj, S; Khodagholi, F; Mohammadi, M; Sharifzadeh, M; Taghizadeh, GH; Yans, A | 1 |
| Choi, H; Hwang, YJ; Jung, ES; Kim, A; Mook-Jung, I; Ryu, H; Song, H | 1 |
| Callaghan, D; Couraud, PO; Liu, QY; Lue, LF; Romero, IA; Stanimirovic, DB; Vukic, V; Walker, D; Weksler, B; Zhang, W | 1 |
| Cho, ES; Hwang, MK; Jang, YJ; Kang, NJ; Kim, YT; Lee, HJ; Lee, KW | 1 |
| Cho, KS; Han, SY; Hong, YK; Jeon, S; Kim, ST; Kim, YK; Koo, BS; Lee, JH; Lee, S; Park, SH | 1 |
| Aiso, S; Chiba, T; Hashimoto, Y; Ichijo, H; Ishizaka, M; Kadowaki, H; Nawa, M; Niikura, T; Nishimoto, I; Nishitoh, H; Terashita, K; Tsukamoto, E; Yamada, M; Yamagishi, Y | 1 |
| Chang, NS; Heath, J; Hsu, LJ; Jambal, P; Pugazhenthi, S; Schultz, L; Su, M; Sze, CI | 1 |
| Nguyen, TV; Pike, CJ; Yao, M | 1 |
12 other study(ies) available for pyrazolanthrone and Alzheimer Disease
| Article | Year |
|---|---|
Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells.
Topics: Adipose Tissue; Alzheimer Disease; Anthracenes; Cell Line, Tumor; Cell Survival; Chromones; Culture Media, Conditioned; Flavonoids; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2015 |
Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anthracenes; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Transgenic; Phenotype; Presenilin-1 | 2015 |
The Streptomyces metabolite anhydroexfoliamycin ameliorates hallmarks of Alzheimer's disease in vitro and in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anthracenes; Antipsychotic Agents; Aspartic Acid Endopeptidases; Brain; Cell Line, Tumor; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; MAP Kinase Kinase Kinases; Mice; Mice, Transgenic; Mutation; Neuroblastoma; Peptide Fragments; Presenilin-1; Prodigiosin; tau Proteins | 2015 |
c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anthracenes; Blotting, Western; Cells, Cultured; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Neurons; Okadaic Acid; Phosphorylation; Rats; Up-Regulation | 2016 |
Reduction of autophagy markers mediated protective effects of JNK inhibitor and bucladesine on memory deficit induced by Aβ in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthracenes; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 7; Beclin-1; Bucladesine; Disease Models, Animal; Drug Therapy, Combination; JNK Mitogen-Activated Protein Kinases; Male; Maze Learning; Memory Disorders; Microtubule-Associated Proteins; Neuroprotective Agents; Protein Kinase Inhibitors; Rats, Wistar; Spatial Memory | 2016 |
p53-dependent SIRT6 expression protects Aβ42-induced DNA damage.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthracenes; Brain; Cell Line; DNA Damage; Down-Regulation; HCT116 Cells; Histones; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lysine; Mice; Mice, Transgenic; Piperazines; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Sirtuins; Tumor Suppressor Protein p53 | 2016 |
Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anthracenes; Brain; Cells, Cultured; Chemokine CCL2; Chemokine CXCL1; Endothelial Cells; Enzyme Inhibitors; Humans; Interleukin-1beta; Interleukin-6; MAP Kinase Kinase 4; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-jun; Signal Transduction; Transcription Factor AP-1; Up-Regulation | 2009 |
Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity.
Topics: Aldehydes; Alzheimer Disease; Animals; Anthracenes; Apoptosis; bcl-X Protein; Biflavonoids; Cacao; Caspase 3; Catechin; Cytoprotection; Enzyme Activation; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; Oxidative Stress; PC12 Cells; Poly(ADP-ribose) Polymerases; Proanthocyanidins; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species | 2009 |
Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthracenes; Apoptosis; Brain; Caspases; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Forkhead Transcription Factors; MAP Kinase Kinase 4; Neurons; Peptide Fragments; Protein Kinase Inhibitors; Signal Transduction | 2012 |
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anthracenes; Carrier Proteins; Dimerization; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Hybrid Cells; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinases; Neurons; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Proteins; Pyridines; Rats; Signal Transduction | 2003 |
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anisomycin; Anthracenes; Brain; Cell Line; Cell Line, Tumor; COS Cells; Down-Regulation; Enzyme Inhibitors; Estradiol; Flavonoids; Genetic Vectors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neurons; Oxidoreductases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Retroviridae; RNA, Small Interfering; Serine; tau Proteins; Temperature; Threonine; Time Factors; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; WW Domain-Containing Oxidoreductase | 2004 |
Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; bcl-X Protein; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Down-Regulation; Enzyme Activation; Gene Expression Regulation; Genes, bcl-2; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitochondrial Proteins; Neurons; Oligopeptides; Peptide Fragments; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Small Interfering | 2005 |