pyrazofurin and Carcinoma--Ehrlich-Tumor

pyrazofurin has been researched along with Carcinoma--Ehrlich-Tumor* in 1 studies

Other Studies

1 other study(ies) available for pyrazofurin and Carcinoma--Ehrlich-Tumor

Article	Year
Synthesis and biological activity of certain 1,2,3-triazole carboxamide nucleosides related to bredinin and pyrazofurin. Nucleic acids symposium series, 1981, Issue:9 5-Hydroxy-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxamide (II) has been prepared by direct glycosylation of the trimethylsilyl derivative of 5-hydroxy-1,2,3-triazole-4-carboxamide (IV). The use of trimethylsilyltrifluoromethane sulfonate as a catalyst and 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose in acetonitrile gave a 95% yield of a 1:1 mixture of V and VI as blocked nucleosides which were readily separated on a silica gel column. The synthesis of II was also achieved by the cycloaddition of 2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl azide with ethyl malonamate. II shows significant antiviral activity against herpes and measles virus in vitro. Topics: Amides; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; IMP Dehydrogenase; Mice; Nucleosides; Pyrazoles; Ribonucleosides; Ribose; Structure-Activity Relationship; Triazoles	1981

Article

Year

Synthesis and biological activity of certain 1,2,3-triazole carboxamide nucleosides related to bredinin and pyrazofurin.

Nucleic acids symposium series, 1981, Issue:9

5-Hydroxy-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxamide (II) has been prepared by direct glycosylation of the trimethylsilyl derivative of 5-hydroxy-1,2,3-triazole-4-carboxamide (IV). The use of trimethylsilyltrifluoromethane sulfonate as a catalyst and 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose in acetonitrile gave a 95% yield of a 1:1 mixture of V and VI as blocked nucleosides which were readily separated on a silica gel column. The synthesis of II was also achieved by the cycloaddition of 2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl azide with ethyl malonamate. II shows significant antiviral activity against herpes and measles virus in vitro.

Topics: Amides; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; IMP Dehydrogenase; Mice; Nucleosides; Pyrazoles; Ribonucleosides; Ribose; Structure-Activity Relationship; Triazoles

1981