pyrazinoic acid has been researched along with Uremia in 2 studies
pyrazinoic acid: active metabolite of pyrazinamide; structure
pyrazine-2-carboxylic acid : The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The serum half-life (t1/2) of PZG was 1 h." | 1.28 | Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs. ( Beyer, KH; Gelarden, RT; Jeszenka, EV; Passananti, GT; Vesell, ES, 1992) |
| " Bioavailability of pyrazinamide was only slightly increased in patients, its dialysis extraction coefficient being 55." | 1.27 | Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure. ( Farinotti, R; Fessi, H; Kenouch, S; Méry, JP; Montes, C; Stamatakis, G; Trouvin, JH, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Passananti, GT | 1 |
| Vesell, ES | 1 |
| Jeszenka, EV | 1 |
| Gelarden, RT | 1 |
| Beyer, KH | 1 |
| Stamatakis, G | 1 |
| Montes, C | 1 |
| Trouvin, JH | 1 |
| Farinotti, R | 1 |
| Fessi, H | 1 |
| Kenouch, S | 1 |
| Méry, JP | 1 |
2 other studies available for pyrazinoic acid and Uremia
| Article | Year |
|---|---|
Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Drug Stabilit | 1992 |
Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure.
Topics: Adult; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pyrazinamide; Renal Dialysis; Tuberculosi | 1988 |