pyrazinoic acid has been researched along with Tuberculosis, Pulmonary in 7 studies
pyrazinoic acid: active metabolite of pyrazinamide; structure
pyrazine-2-carboxylic acid : The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
Tuberculosis, Pulmonary: MYCOBACTERIUM infections of the lung.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrazinamide (PZA) is a critical component of current first-line TB therapy." | 1.48 | Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis. ( Braunstein, M; Durham, PG; Hayden, JD; Hickey, AJ; Lin, FC; Miller, BK; Montgomery, SA; Rank, L; Welch, JT; Young, EF; Zulauf, KE, 2018) |
| "Pyrazinamide (PZA) is an important drug in the treatment of tuberculosis." | 1.38 | A new approach for pyrazinamide susceptibility testing in Mycobacterium tuberculosis. ( Cotrina, M; Fuentes, P; Gilman, RH; Gutierrez, A; Kirwan, D; Loli, S; Sheen, P; Zimic, M, 2012) |
| " Bioavailability of pyrazinamide was only slightly increased in patients, its dialysis extraction coefficient being 55." | 1.27 | Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure. ( Farinotti, R; Fessi, H; Kenouch, S; Méry, JP; Montes, C; Stamatakis, G; Trouvin, JH, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Montgomery, SA | 1 |
| Young, EF | 1 |
| Durham, PG | 1 |
| Zulauf, KE | 1 |
| Rank, L | 1 |
| Miller, BK | 1 |
| Hayden, JD | 1 |
| Lin, FC | 1 |
| Welch, JT | 2 |
| Hickey, AJ | 1 |
| Braunstein, M | 1 |
| Meinzen, C | 1 |
| Proaño, A | 1 |
| Gilman, RH | 2 |
| Caviedes, L | 1 |
| Coronel, J | 1 |
| Zimic, M | 2 |
| Sheen, P | 2 |
| Loli, S | 1 |
| Gutierrez, A | 1 |
| Fuentes, P | 1 |
| Cotrina, M | 1 |
| Kirwan, D | 1 |
| Sarma, GR | 1 |
| Acharyulu, GS | 1 |
| Kannapiran, M | 1 |
| Murthy, PV | 1 |
| Gurumurthy, P | 1 |
| Tripathy, SP | 1 |
| Draper, P | 1 |
| Zimhony, O | 1 |
| Cox, JS | 1 |
| Vilchèze, C | 1 |
| Jacobs, WR | 1 |
| Stamatakis, G | 1 |
| Montes, C | 1 |
| Trouvin, JH | 1 |
| Farinotti, R | 1 |
| Fessi, H | 1 |
| Kenouch, S | 1 |
| Méry, JP | 1 |
7 other studies available for pyrazinoic acid and Tuberculosis, Pulmonary
| Article | Year |
|---|---|
Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis.
Topics: Aerosols; Animals; Antitubercular Agents; Bacterial Load; Disease Models, Animal; Drug Therapy, Comb | 2018 |
A quantitative adaptation of the Wayne test for pyrazinamide resistance.
Topics: Adult; Antitubercular Agents; Area Under Curve; Calibration; Drug Resistance, Bacterial; Female; Hum | 2016 |
A new approach for pyrazinamide susceptibility testing in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Biological Transport; Biotransformation; Drug Resistance, Bacterial; Humans; | 2012 |
Role of rifampicin in arthralgia induced by pyrazinamide.
Topics: Drug Therapy, Combination; Humans; Joint Diseases; Pain; Pyrazinamide; Rifampin; Tuberculosis, Pulmo | 1983 |
Lipid biochemistry takes a stand against tuberculosis.
Topics: Acetyltransferases; Antitubercular Agents; Bacterial Proteins; Drug Therapy, Combination; Fatty Acid | 2000 |
Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Bacterial Proteins; Enzyme Inhibitors; Fatty Acid Synthases; Humans; | 2000 |
Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure.
Topics: Adult; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pyrazinamide; Renal Dialysis; Tuberculosi | 1988 |