pyrazinoic acid has been researched along with Extensively Drug-Resistant Tuberculosis in 2 studies
pyrazinoic acid: active metabolite of pyrazinamide; structure
pyrazine-2-carboxylic acid : The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
Extensively Drug-Resistant Tuberculosis: Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrazinamide (PZA) is an antibiotic used in first- and second-line tuberculosis treatment regimens." | 1.56 | Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid. ( Amzel, LM; Antiparra, R; Gilman, RH; Kirwan, DE; Lopez, JM; Maruenda, H; Saavedra, H; Sheen, P; Toscano, E; Vallejos-Sánchez, K; Zimic, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vallejos-Sánchez, K | 1 |
| Lopez, JM | 1 |
| Antiparra, R | 1 |
| Toscano, E | 1 |
| Saavedra, H | 1 |
| Kirwan, DE | 1 |
| Amzel, LM | 1 |
| Gilman, RH | 1 |
| Maruenda, H | 1 |
| Sheen, P | 1 |
| Zimic, M | 1 |
| Kim, HJ | 1 |
| Kwak, HK | 1 |
| Lee, J | 1 |
| Yun, YJ | 1 |
| Lee, JS | 1 |
| Lee, MS | 1 |
| Min, SY | 1 |
| Park, SK | 1 |
| Kang, HS | 1 |
| Maeng, YH | 1 |
| Kim, SY | 2 |
| Kook, YH | 1 |
| Kim, YR | 1 |
| Lee, KH | 1 |
2 other studies available for pyrazinoic acid and Extensively Drug-Resistant Tuberculosis
| Article | Year |
|---|---|
Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Extensively Drug-Re | 2020 |
Patterns of pncA mutations in drug-resistant Mycobacterium tuberculosis isolated from patients in South Korea.
Topics: Adult; Amidohydrolases; Antitubercular Agents; Bacterial Proteins; Base Sequence; DNA Mutational Ana | 2012 |