pyrazinoic acid has been researched along with Acute Liver Injury, Drug-Induced in 2 studies
pyrazinoic acid: active metabolite of pyrazinamide; structure
pyrazine-2-carboxylic acid : The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with caffeine, nicotinic acid or non-substituted pyrazinoic acid activated the LPS/D-GalN induced elevation of plasma IL-10 levels at 1 and 2 h, although there were no statistically significant differences in IL-10 levels between control and nicotinic acid or non-substituted pyrazinoic acid treated rats." | 1.35 | Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats. ( Akashi, I; Hirano, T; Kagami, K; Oka, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rawat, A | 1 |
| Chaturvedi, S | 1 |
| Singh, AK | 1 |
| Guleria, A | 1 |
| Dubey, D | 1 |
| Keshari, AK | 1 |
| Raj, V | 1 |
| Rai, A | 1 |
| Prakash, A | 1 |
| Kumar, U | 1 |
| Kumar, D | 1 |
| Saha, S | 1 |
| Akashi, I | 1 |
| Kagami, K | 1 |
| Hirano, T | 1 |
| Oka, K | 1 |
2 other studies available for pyrazinoic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Metabolomics approach discriminates toxicity index of pyrazinamide and its metabolic products, pyrazinoic acid and 5-hydroxy pyrazinoic acid.
Topics: Administration, Oral; Animals; Antitubercular Agents; Biomarkers; Biotransformation; Chemical and Dr | 2018 |
Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug I | 2009 |