Page last updated: 2024-08-21

pyrazines and Thrombosis

pyrazines has been researched along with Thrombosis in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's4 (13.33)18.2507
2000's10 (33.33)29.6817
2010's12 (40.00)24.3611
2020's3 (10.00)2.80

Authors

AuthorsStudies
Fu, K; Gong, L; Guo, C; He, L; Li, Y; Liao, L; Ma, C; Peng, C; Wang, C; Zhang, Y; Zhou, H1
Li, J; Lv, H; Qu, B; Yang, L; Yang, X; Yuan, L1
Parhofer, KG1
Macip, S; Massip-Salcedo, M; Qusairy, Z; Rada, M1
Brandl, R; Busygina, K; Deckmyn, H; Jamasbi, J; Lorenz, R; Seiler, T; Siess, W; Weber, C1
Garcia, C; Levade, M; Payrastre, B; Series, J; SiƩ, P; Viaud, J; Ysebaert, L1
Bernlochner, I; Busygina, K; Denzinger, V; Lorenz, R; Siess, W; Weber, C1
Cai, X; Chen, P; Chen, Z; Ge, J; Hu, H; Li, K; Pan, X; Xia, L; Yang, Y; Yu, K; Zhang, J; Zhuang, J1
Asaka, M; Fujita, N; Hashino, S; Imamura, M; Kahata, K; Kondo, T; Morita, R; Onozawa, M; Shirai, S1
Coleman, M; Mark, T; Niesvizky, R1
Eby, C1
de Maat, MP; Leebeek, FW; Libourel, EJ; Sonneveld, P; van der Holt, B1
Connolly, G1
Guo, HF; Mao, JJ; Su, HL; Sun, C; Wang, J; Zhou, X1
Brioli, A; Cavo, M; Pantani, L; Tacchetti, P; Zamagni, E; Zannetti, B1
De Nanteuil, G; Gloanec, P; Marx, I; Mennecier, P; Rupin, A; Vallez, MO; Verbeuren, TJ1
Gil, L; Komarnicki, M; Rupa-Matysek, J1
Morgan, G1
Bohn, D; Burgey, CS; Chen, Z; Clayton, FC; Cook, JJ; Gardell, SJ; Isaacs, RC; Krueger, JA; Kuo, L; Lewis, SD; Lucas, BJ; Lyle, EA; Lyle, TA; Lynch, JJ; McMasters, DR; Miller-Stein, C; Nantermet, PG; Pal, S; Pellicore, JM; Robinson, KA; Selnick, HG; Shafer, JA; Singh, R; Stranieri, MT; Vacca, JP; Wallace, AA; Welsh, DC; White, RB; Wong, B; Yan, Y1
Case, BL; Clare, M; Girard, TJ; Hayes, MJ; Jones, DE; Kurumbail, RG; Lachance, RM; Nicholson, NS; Parlow, JJ; South, MS; Stallings, WC; Stegeman, RA; Stevens, AM; Wood, RS1
LaChance, RM; Nicholson, NS; Parlow, JJ; Salyers, AK; South, MS; Suleymanov, OD; Szalony, JA; Wood, RS1
Chen, LJ; Chen, Z; Ding, S; Feng, Y; Ma, GS; Shen, CX1
Li, H; Liu, JY; Meng, JR; Yin, WT1
Nakano, M; Nakashima, M; Nishiyama, H; Saniabadi, AR; Takiguchi, Y; Umemura, K; Wada, K1
Kawamura, M; Moriya, N; Terashita, Z; Tsuji, N1
Liao, F1
Goto, S; Handa, S; Ikeda, Y; Li, M1
Ruan, Q; Song, J1
Ma, HT; Ruan, CG; Wu, GX; Wu, JC1
Liu, SY; Sylvester, DM1

Reviews

6 review(s) available for pyrazines and Thrombosis

ArticleYear
    MMW Fortschritte der Medizin, 2020, Volume: 162, Issue:5

    Topics: Aspirin; Humans; Pyrazines; Randomized Controlled Trials as Topic; Thrombosis; Treatment Outcome; Venous Thromboembolism

2020
Relevance of the Bruton Tyrosine Kinase as a Target for COVID-19 Therapy.
    Molecular cancer research : MCR, 2021, Volume: 19, Issue:4

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antiviral Agents; Benzamides; COVID-19; COVID-19 Drug Treatment; Humans; Lung; Molecular Targeted Therapy; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrazines; Thrombosis

2021
Btk Inhibitors as First Oral Atherothrombosis-Selective Antiplatelet Drugs?
    Thrombosis and haemostasis, 2019, Volume: 119, Issue:8

    Topics: Adenine; Administration, Oral; Agammaglobulinaemia Tyrosine Kinase; Agammaglobulinemia; Animals; Arteries; B-Lymphocytes; Benzamides; Blood Platelets; Cell Differentiation; Genetic Diseases, X-Linked; Hemorrhage; Humans; Imidazoles; Mice; Piperidines; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Signal Transduction; Thrombosis

2019
Pathogenesis and management of bleeding and thrombosis in plasma cell dyscrasias.
    British journal of haematology, 2009, Volume: 145, Issue:2

    Topics: Blood Coagulation Disorders; Blood Platelet Disorders; Boronic Acids; Bortezomib; Hemorrhage; Humans; Immunosuppressive Agents; Paraproteinemias; Protease Inhibitors; Pyrazines; Retrospective Studies; Thalidomide; Thrombosis

2009
[Thrombotic complications following the treatment of multiple myeloma with new agents].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2011, Volume: 31, Issue:186

    Topics: Anthracyclines; Anticoagulants; Antineoplastic Agents; Boronic Acids; Bortezomib; Dexamethasone; Drug Therapy, Combination; Humans; Lenalidomide; Multiple Myeloma; Pyrazines; Thalidomide; Thrombosis

2011
Herbs of activating blood circulation to remove blood stasis.
    Clinical hemorheology and microcirculation, 2000, Volume: 23, Issue:2-4

    Topics: Aged; Animals; Anticoagulants; Blood Viscosity; Cardiovascular Agents; Coronary Disease; Drugs, Chinese Herbal; Fibrinolytic Agents; Hemodynamics; Hemorheology; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazines; Rats; Rats, Wistar; Stroke; Thrombosis

2000

Other Studies

24 other study(ies) available for pyrazines and Thrombosis

ArticleYear
Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Animals; Antioxidants; Fibrinolytic Agents; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Ligusticum; Pyrazines; Thrombosis; Zebrafish

2022
Polyurethane End-Capped by Tetramethylpyrazine-Nitrone for Promoting Endothelialization Under Oxidative Stress.
    Advanced healthcare materials, 2019, Volume: 8, Issue:20

    Topics: Animals; Antioxidants; Apoptosis; Biocompatible Materials; Blood Vessel Prosthesis; Cell Adhesion; Cell Proliferation; Free Radical Scavengers; Free Radicals; Human Umbilical Vein Endothelial Cells; Humans; Mice; Neuroprotective Agents; NIH 3T3 Cells; Oxidative Stress; Oxygen; Platelet Adhesiveness; Polymers; Polyurethanes; Pyrazines; Rabbits; Tensile Strength; Thrombosis; Tissue Engineering

2019
Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque-triggered thrombus formation in humans.
    Blood, 2018, 06-14, Volume: 131, Issue:24

    Topics: Adenine; Administration, Oral; Adult; Agammaglobulinaemia Tyrosine Kinase; Aged; Benzamides; Humans; Imidazoles; Male; Middle Aged; Piperidines; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Thrombosis

2018
Differences and similarities in the effects of ibrutinib and acalabrutinib on platelet functions.
    Haematologica, 2019, Volume: 104, Issue:11

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Benzamides; Blood Platelets; Humans; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Signal Transduction; Thrombosis

2019
Inhibition of angiogenesis, fibrosis and thrombosis by tetramethylpyrazine: mechanisms contributing to the SDF-1/CXCR4 axis.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Cell Line; Cell Movement; Chemokine CXCL12; Cornea; Humans; Lung; Male; Neovascularization, Pathologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Fibrosis; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Signal Transduction; Thrombosis

2014
Thrombotic microangiopathy after treatment with bortezomib and dexamethasone in a patient with multiple myeloma.
    International journal of hematology, 2008, Volume: 88, Issue:2

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Dexamethasone; Drug Therapy, Combination; Glucocorticoids; Humans; Male; Microcirculation; Middle Aged; Multiple Myeloma; Pyrazines; Thrombosis

2008
Novel agents in myeloma: an exciting saga.
    Cancer, 2009, Jan-15, Volume: 115, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Dexamethasone; Humans; Immunosuppressive Agents; Lenalidomide; Multiple Myeloma; Pyrazines; Randomized Controlled Trials as Topic; Survival Analysis; Thalidomide; Thrombosis

2009
High incidence of arterial thrombosis in young patients treated for multiple myeloma: results of a prospective cohort study.
    Blood, 2010, Jul-08, Volume: 116, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Clinical Trials, Phase III as Topic; Dexamethasone; Doxorubicin; Female; Humans; Incidence; Male; Middle Aged; Multiple Myeloma; Multivariate Analysis; Outcome Assessment, Health Care; Proportional Hazards Models; Prospective Studies; Pyrazines; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Thalidomide; Thrombosis; Vincristine

2010
The impact of bortezomib on the risk of thrombosis in multiple myeloma.
    Leukemia research, 2011, Volume: 35, Issue:2

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Multiple Myeloma; Pyrazines; Risk Factors; Thrombosis

2011
Stroke after treatment with bortezomib and dexamethasone in a Chinese patient with extramedullary relapse of multiple myeloma.
    International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; China; Dexamethasone; Humans; Male; Multiple Myeloma; Pyrazines; Recurrence; Stroke; Thrombosis; Treatment Outcome

2010
Multiple myeloma, venous thromboembolism, and treatment-related risk of thrombosis.
    Seminars in thrombosis and hemostasis, 2011, Volume: 37, Issue:3

    Topics: Activated Protein C Resistance; Aged; Anticoagulants; Aspirin; Boronic Acids; Bortezomib; Dexamethasone; Humans; Immunologic Factors; International Normalized Ratio; Lenalidomide; Multiple Myeloma; Proteasome Inhibitors; Pyrazines; Risk Factors; Thalidomide; Thrombosis; Venous Thromboembolism; Warfarin

2011
S35972, a direct-acting thrombin inhibitor with high oral bioavailability and antithrombotic efficacy.
    Journal of thrombosis and haemostasis : JTH, 2011, Volume: 9, Issue:7

    Topics: Administration, Oral; Animals; Anticoagulants; Benzimidazoles; Biological Availability; Blood Coagulation Tests; Dabigatran; Disease Models, Animal; Dogs; Drug Evaluation; Humans; In Vitro Techniques; Inhibitory Concentration 50; Pyrazines; Pyridines; Pyrroles; Rats; Thrombin; Thrombosis

2011
Myeloma: diagnosis complications and supportive care.
    Hematology (Amsterdam, Netherlands), 2012, Volume: 17 Suppl 1

    Topics: Amyloidosis; Anemia; Antineoplastic Agents; Bone Density Conservation Agents; Bone Diseases; Boronic Acids; Bortezomib; Diphosphonates; Humans; Imidazoles; Multiple Myeloma; Pyrazines; Quality of Life; Renal Insufficiency; Thrombosis; Zoledronic Acid

2012
Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.
    Bioorganic & medicinal chemistry letters, 2003, Apr-07, Volume: 13, Issue:7

    Topics: Acetamides; Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Dogs; Half-Life; Humans; In Vitro Techniques; Injections, Intravenous; Macaca mulatta; Microsomes, Liver; Models, Molecular; Oxides; Pyrazines; Pyridines; Rats; Solubility; Structure-Activity Relationship; Thrombin; Thrombosis

2003
Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
    Bioorganic & medicinal chemistry letters, 2003, Jul-21, Volume: 13, Issue:14

    Topics: Crystallography, X-Ray; Drug Design; Factor VIIa; Factor Xa Inhibitors; Fibrinolytic Agents; Indicators and Reagents; Models, Molecular; Molecular Conformation; Peptide Library; Prothrombin; Pyrazines; Structure-Activity Relationship; Thrombin; Thrombosis; Trypsin Inhibitors

2003
Pharmacological interruption of acute thrombus formation with minimal hemorrhagic complications by a small molecule tissue factor/factor VIIa inhibitor: comparison to factor Xa and thrombin inhibition in a nonhuman primate thrombosis model.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:3

    Topics: Aminobenzoates; Animals; Bleeding Time; Dose-Response Relationship, Drug; Factor VIIa; Factor Xa Inhibitors; Fibrinolytic Agents; Forearm; Hemodynamics; Macaca fascicularis; Male; Prothrombin Time; Pyrazines; Sodium Chloride; Thrombin; Thromboplastin; Thrombosis

2003
Biocompatibility of tetramethylpyrazine-eluting stents in normal porcine coronary arteries.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2008, Volume: 62, Issue:2

    Topics: Animals; Coated Materials, Biocompatible; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Drug-Eluting Stents; Kidney; Liver; Platelet Aggregation Inhibitors; Pyrazines; Swine; Thrombosis; Time Factors; Tunica Intima

2008
[Effect of tetramethylpyrazine on experimental thrombosis formation (author's transl)].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1981, Volume: 2, Issue:4

    Topics: Animals; Female; Fibrinolytic Agents; Male; Platelet Aggregation; Pyrazines; Rabbits; Rats; Thrombosis

1981
A chemiluminescent detection of superoxide radical produced by adherent leucocytes to the subendothelium following thrombolysis: studies with a photochemically induced thrombosis model in the guinea pig femoral artery.
    Atherosclerosis, 1996, Volume: 122, Issue:2

    Topics: Animals; Cell Adhesion; Disease Models, Animal; Endothelium, Vascular; Femoral Artery; Guinea Pigs; Imidazoles; Light; Luminescent Measurements; Male; Neutrophils; Plasminogen Activators; Pyrazines; Recombinant Proteins; Rose Bengal; Superoxides; Thrombolytic Therapy; Thrombosis

1996
Effects of TAK-029, a novel GPIIb/IIIa antagonist, on arterial thrombosis in guinea pigs, dogs and monkeys.
    Thrombosis research, 1997, May-15, Volume: 86, Issue:4

    Topics: Animals; Basilar Artery; Bleeding Time; Carotid Artery Thrombosis; Coronary Thrombosis; Disease Models, Animal; Dogs; Female; Guanidines; Guinea Pigs; Injections, Intravenous; Macaca fascicularis; Male; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrazines; Thrombosis

1997
Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine 'Chuanxiong,' on platelet thrombus formation under high shear rates.
    Thrombosis research, 2001, Oct-01, Volume: 104, Issue:1

    Topics: Blood Platelets; Blood Viscosity; Collagen; Drugs, Chinese Herbal; Humans; Ligusticum; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding; Pyrazines; Stress, Mechanical; Thrombosis; von Willebrand Factor

2001
Mechanism of ligustrazini against thrombosis.
    Chinese medical journal, 2000, Volume: 113, Issue:2

    Topics: Binding, Competitive; Blotting, Northern; Cells, Cultured; Drugs, Chinese Herbal; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Fibrinolytic Agents; Humans; NF-kappa B; Plasminogen Activator Inhibitor 1; Pyrazines; RNA, Messenger; Thrombosis

2000
Inhibitory effects of tetramethylpyrazine on platelets during cardiopulmonary bypass and arterial thrombus formation in dogs.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:4

    Topics: Animals; Blood Platelets; Cardiopulmonary Bypass; Cell Adhesion Molecules; Dogs; Female; Male; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Membrane Glycoproteins; Pyrazines; Thrombosis

1992
Antithrombotic/antiplatelet activity of tetramethylpyrazine.
    Thrombosis research, 1990, Apr-15, Volume: 58, Issue:2

    Topics: Animals; Biological Transport, Active; Calcium Channel Blockers; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazines; Rats; Rats, Inbred Strains; Thrombosis

1990