Compounds > pyrazines
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pyrazines and Squamous Cell Carcinoma of Head and Neck

pyrazines has been researched along with Squamous Cell Carcinoma of Head and Neck in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (58.33)24.3611
2020's5 (41.67)2.80

Authors

AuthorsStudies
Adkins, D; Algazi, A; Betts, CB; Cohen, EEW; Coussens, LM; Goldschmidt, JH; Guarino, MJ; Jimeno, A; Maloney, L; Munugalavadla, V; Nadler, E; Nemunaitis, J; Patel, P; Tao, L; Taylor, MH1
Axelrod, MJ; Bekiranov, S; David, AP; Donaldson, L; Dougherty, MI; Frierson, HF; Gioeli, DG; Hubbard, MA; Jameson, MJ; Khalil, AA; Lehman, CE; McGarey, PO; Mendez, RE; Petricoin, EF; Schoeff, SS; Stelow, EB; Taniguchi, LE; Wulfkuhle, JD1
Della Manna, DL; Nikolaev, A; Xing, C; Yang, ES; Zeng, L1
Distel, L; Dobler, C; Fietkau, R; Hecht, M; Jost, T1
Arasaki, A; Kawabata-Iwakawa, R; Kina, S; Kinjo, T; Miyamoto, S; Sunakawa, H1
Jin, X; Li, XF; Wang, JY; Zhang, X1
Johnson, DE; Li, C2
Beggs, RR; Cooper, TS; Weaver, AN; Yang, ES; Zeng, L1
Ahsan, A; Arai, Y; Argiris, A; Chen, Z; Cooley-Zgela, T; Duffy, AG; Jang, M; Kannabiran, VR; Kim, SW; Kummar, S; Nyati, MK; Ramanand, SG; Rudy, SF; Simone, NL; Suksta, N; Van Waes, C; Wright, JJ; Yang, X1
Argiris, A; Arun, P; Feldman, LE; Forastiere, AA; Gilbert, J; Haigentz, M; Jang, M; Lee, JW; Van Waes, C1
Chan, ET; DeLancey, HM; Freilino, ML; Grandis, JR; Johnson, DE; Kirk, CJ; Li, C; Thomas, SM; Zang, Y1

Trials

3 trial(s) available for pyrazines and Squamous Cell Carcinoma of Head and Neck

ArticleYear
Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, Mar-01, Volume: 28, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Head and Neck Neoplasms; Humans; Programmed Cell Death 1 Receptor; Proteomics; Pyrazines; Squamous Cell Carcinoma of Head and Neck

2022
Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Sep-01, Volume: 17, Issue:17

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Cytokines; Disease Progression; ErbB Receptors; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Protease Inhibitors; Pyrazines; Radiotherapy, Intensity-Modulated; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Transcription Factors; Treatment Outcome

2011
Phase II 2-arm trial of the proteasome inhibitor, PS-341 (bortezomib) in combination with irinotecan or PS-341 alone followed by the addition of irinotecan at time of progression in patients with locally recurrent or metastatic squamous cell carcinoma of
    Head & neck, 2013, Volume: 35, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Camptothecin; Carcinoma, Squamous Cell; Cytokines; Disease Progression; Female; Head and Neck Neoplasms; Humans; Irinotecan; Male; Middle Aged; NF-kappa B; Pyrazines; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome

2013

Other Studies

9 other study(ies) available for pyrazines and Squamous Cell Carcinoma of Head and Neck

ArticleYear
Antitumor effect of insulin-like growth factor-1 receptor inhibition in head and neck squamous cell carcinoma.
    The Laryngoscope, 2020, Volume: 130, Issue:6

    Topics: Head and Neck Neoplasms; Humans; Imidazoles; Insulin-Like Growth Factor I; Mouth Neoplasms; Neoplasm Staging; Pyrazines; Pyrazoles; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Triazines; Tumor Cells, Cultured

2020
CHK1/2 Inhibitor Prexasertib Suppresses NOTCH Signaling and Enhances Cytotoxicity of Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma.
    Molecular cancer therapeutics, 2020, Volume: 19, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Checkpoint Kinase 1; Checkpoint Kinase 2; Chemoradiotherapy; Cisplatin; DNA Damage; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Pyrazines; Pyrazoles; Receptors, Notch; Squamous Cell Carcinoma of Head and Neck; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
    Cells, 2020, 09-01, Volume: 9, Issue:9

    Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Line, Tumor; Cellular Senescence; DNA Damage; Fibroblasts; Head and Neck Neoplasms; Humans; Isoxazoles; Male; Protein Kinase Inhibitors; Pyrazines; Pyridines; Quinolines; Radiation, Ionizing; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Triazoles

2020
A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates.
    Journal of drug targeting, 2021, Volume: 29, Issue:10

    Topics: Administration, Metronomic; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Drug Synergism; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Pyrazines; Pyridines; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck; Survival Rate; Tongue Neoplasms; Wnt Signaling Pathway; Young Adult

2021
CC-223 inhibits human head and neck squamous cell carcinoma cell growth.
    Biochemical and biophysical research communications, 2018, 02-19, Volume: 496, Issue:4

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Head and Neck Neoplasms; Humans; Protein Kinase Inhibitors; Pyrazines; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Treatment Outcome

2018
Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive head and neck squamous cell carcinoma cells promotes apoptosis and cell cycle arrest.
    Cell cycle (Georgetown, Tex.), 2013, Mar-15, Volume: 12, Issue:6

    Topics: Apoptosis; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Head and Neck Neoplasms; Human papillomavirus 16; Humans; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Papillomavirus Infections; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Repressor Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Squamous Cell Carcinoma of Head and Neck; Tumor Suppressor Protein p53; Ubiquitination

2013
Combining Chk1/2 Inhibition with Cetuximab and Radiation Enhances
    Molecular cancer therapeutics, 2017, Volume: 16, Issue:4

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cetuximab; Checkpoint Kinase 1; Checkpoint Kinase 2; Chemoradiotherapy; Combined Modality Therapy; DNA Damage; Drug Synergism; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Mice; Pyrazines; Pyrazoles; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays

2017
Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation.
    Cancer letters, 2012, Jan-01, Volume: 314, Issue:1

    Topics: Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cell Line, Tumor; Enzyme Activation; Head and Neck Neoplasms; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Squamous Cell Carcinoma of Head and Neck

2012
The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4.
    Autophagy, 2012, Volume: 8, Issue:12

    Topics: Activating Transcription Factor 4; Autophagy; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Head and Neck Neoplasms; Humans; Models, Biological; Oligopeptides; Proteasome Inhibitors; Pyrazines; Squamous Cell Carcinoma of Head and Neck; Unfolded Protein Response

2012